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31.
Eleonora Di Campi Mauro Di Pasquale 《Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment》2020,37(5):753-762
ABSTRACTFatty acid esters of 3-monochloropropanediol (3-MCPD), 2-MCPD and glycidol (Gly) are food-processing contaminants that cause concerns about possible adverse health effects. The present study evaluates the contamination levels of the three ester classes in 130 samples of foodstuffs marketed in Italy covering 10 food categories, namely margarines, oils, roasted coffee, breakfast cereals, salted crackers, cookies, infant biscuits, rusks, breads and potato crisps. The analytical method employed is a so-called indirect method that entails MCPD/glycidol cleavage from their esterified forms, cleanup, derivatisation and GC-MS analysis. The MCPDs and glycidol concentrations (from esters) were found to be equal or a little higher than the levels reported in previous studies conducted in other European countries and described in the literature. 3-MCPD was the predominant compound in all foodstuffs analysed with the exception for rusks where Gly levels were slightly higher. Considering the sum of MCPD and Gly esters, the most contaminated foodstuffs were seed oils, followed by margarines and cookies, whereas roasted coffee, bread, rusks, cornflakes and infant biscuits were less contaminated with MCPDs and Gly concentrations often below LOQ or LOD values. Refined olive oil, potato chips and salted crackers showed contamination levels intermediate between the two above groups. The results of this study also confirm that the use of palm oil as an ingredient or frying medium is an important cause of increase of the levels of MCPD and Gly esters, especially in salted crackers, rusks and potato crisps. Finally, the Italian intake of 3-MCPD due to the various foods analysed has been calculated and related to TDI. The MoE for Gly was also estimated. 相似文献
32.
Maral Mahdad Chiara Eleonora De Marco Andrea Piccaluga Alberto Di Minin 《Industry and innovation》2020,27(3):264-284
ABSTRACTThis paper focuses on how companies deploy structural properties of adaptive capacity (multiplexity, redundancy and loose coupling) to cope with the phenomenon of internal challenges of Open Innovation (OI) implementation, i.e. organisational and cultural changes. We developed a single case study, which offered significant findings. First, the multiplexity of relationships in OI settings helps to face the challenges of organisational and cultural changes by triggering trust formation and interaction. Second, redundancy has twofold elements: institutional logics redundancy triggers cultural change challenges which can be overcome through management practices and communications; task redundancy facilitates knowledge sharing and collaboration, thus helping to deal with organisational change challenges. Finally, loose coupling in OI settings facilitates social interconnectedness among members through management practices, helping to face organisational and cultural change challenges. We provide managerial and theoretical implication to deal with the challenges of OI in relation to both organisational and cultural changes. 相似文献
33.
Andrea Luca Tasca Eleonora Stefanelli Anna Maria Raspolli Galletti Riccardo Gori Gemma Mannarino Sandra Vitolo Monica Puccini 《化学工程与技术》2020,43(12):2382-2392
Hydrothermal carbonization of sewage sludge was carried out with the aim to evaluate the influence of process severity and initial solid content. Response surface methodology was applied to model yield and C yield responses. Enhanced dewaterability performance was recorded under mild processing conditions. The treatment promoted concentration and immobilization of Pb, Cd, Ni, Zn, and Cu. Variation of the solid content showed a stronger influence than severity on average yield and C yield. Higher heating values (HHVs) and energy retention efficiencies (EREs) of hydrochars obtained at the lowest solid content displayed the lowest values. Hence, the energy requirements of a first dewatering step should be compared with the related improvement in terms of HHV and ERE when sludge is used as feedstock. 相似文献
34.
Raffaella Balestrini Cecilia Brunetti Maria Cammareri Sofia Caretto Valeria Cavallaro Eleonora Cominelli Monica De Palma Teresa Docimo Giovanna Giovinazzo Silvana Grandillo Franca Locatelli Erica Lumini Dario Paolo Cristina Patan Francesca Sparvoli Marina Tucci Elisa Zampieri 《International journal of molecular sciences》2021,22(6)
Plant specialized metabolites (SMs) play an important role in the interaction with the environment and are part of the plant defense response. These natural products are volatile, semi-volatile and non-volatile compounds produced from common building blocks deriving from primary metabolic pathways and rapidly evolved to allow a better adaptation of plants to environmental cues. Specialized metabolites include terpenes, flavonoids, alkaloids, glucosinolates, tannins, resins, etc. that can be used as phytochemicals, food additives, flavoring agents and pharmaceutical compounds. This review will be focused on Mediterranean crop plants as a source of SMs, with a special attention on the strategies that can be used to modulate their production, including abiotic stresses, interaction with beneficial soil microorganisms and novel genetic approaches. 相似文献
35.
Lucia Marseglia Sara Manti Gabriella D’Angelo Antonio Nicotera Eleonora Parisi Gabriella Di Rosa Eloisa Gitto Teresa Arrigo 《International journal of molecular sciences》2015,16(1):378-400
Obesity, a social problem worldwide, is characterized by an increase in body weight that results in excessive fat accumulation. Obesity is a major cause of morbidity and mortality and leads to several diseases, including metabolic syndrome, diabetes mellitus, cardiovascular, fatty liver diseases, and cancer. Growing evidence allows us to understand the critical role of adipose tissue in controlling the physic-pathological mechanisms of obesity and related comorbidities. Recently, adipose tissue, especially in the visceral compartment, has been considered not only as a simple energy depository tissue, but also as an active endocrine organ releasing a variety of biologically active molecules known as adipocytokines or adipokines. Based on the complex interplay between adipokines, obesity is also characterized by chronic low grade inflammation with permanently increased oxidative stress (OS). Over-expression of oxidative stress damages cellular structures together with under-production of anti-oxidant mechanisms, leading to the development of obesity-related complications. The aim of this review is to summarize what is known in the relationship between OS in obesity and obesity-related diseases. 相似文献
36.
Diana Boraschi Andi Alijagic Manon Auguste Francesco Barbero Eleonora Ferrari Szabolcs Hernadi Craig Mayall Sara Michelini Natividad I. Navarro Pacheco Alessandra Prinelli Elmer Swart Benjamin J. Swartzwelter Neus G. Bastús Laura Canesi Damjana Drobne Albert Duschl Marie‐Ann Ewart Jutta Horejs‐Hoeck Paola Italiani Birgit Kemmerling Peter Kille Petra Prochazkova Victor F. Puntes David J. Spurgeon Claus Svendsen Colin J. Wilde Annalisa Pinsino 《Small (Weinheim an der Bergstrasse, Germany)》2020,16(21)
The interaction of a living organism with external foreign agents is a central issue for its survival and adaptation to the environment. Nanosafety should be considered within this perspective, and it should be examined that how different organisms interact with engineered nanomaterials (NM) by either mounting a defensive response or by physiologically adapting to them. Herein, the interaction of NM with one of the major biological systems deputed to recognition of and response to foreign challenges, i.e., the immune system, is specifically addressed. The main focus is innate immunity, the only type of immunity in plants, invertebrates, and lower vertebrates, and that coexists with adaptive immunity in higher vertebrates. Because of their presence in the majority of eukaryotic living organisms, innate immune responses can be viewed in a comparative context. In the majority of cases, the interaction of NM with living organisms results in innate immune reactions that eliminate the possible danger with mechanisms that do not lead to damage. While in some cases such interaction may lead to pathological consequences, in some other cases beneficial effects can be identified. 相似文献
37.
Anna Maria Piras Ylenia Zambito Susi Burgalassi Daniela Monti Silvia Tampucci Eleonora Terreni Angela Fabiano Federica Balzano Gloria Uccello-Barretta Patrizia Chetoni 《Journal of materials science. Materials in medicine》2018,29(4):42
The ocular bioavailability of lipophilic drugs, such as dexamethasone, depends on both drug water solubility and mucoadhesion/permeation. Cyclodextrins and chitosan are frequently employed to either improve drug solubility or prolong drug contact onto mucosae, respectively. Although the covalent conjugation of cyclodextrin and chitosan brings to mucoadhesive drug complexes, their water solubility is restricted to acidic pHs. This paper describes a straightforward grafting of methyl-β-cyclodextrin (MCD) on quaternary ammonium chitosan (QA-Ch60), mediated by hexamethylene diisocyanate. The resulting product is a water-soluble chitosan derivative, having a 10-atom long spacer between the quaternized chitosan and the cyclodextrin. The derivative is capable of complexing the model drug dexamethasone and stable complexes were also observed for the lyophilized products. Furthermore, the conjugate preserves the mucoadhesive properties typical of quaternized chitosan and its safety as solubilizing excipient for ophthalmic applications was preliminary assessed by in vitro cytotoxicity evaluations. Taken as a whole, the observed features appear promising for future processing of the developed product into 3D solid forms, such as controlled drug delivery systems, films or drug eluting medical devices. 相似文献
38.
Brunella Parodi Eleonora Russo Sara Baldassari Guendalina Zuccari Sara Pastorino Mengying Yan 《Drug development and industrial pharmacy》2017,43(6):917-924
Objective: The aim of this work was the development of mucoadhesive sublingual films, prepared using a casting method, for the administration of oxycodone.Materials and methods: A solvent casting method was employed to prepare the mucoadhesive films. A calibrated pipette was used to deposit single aliquots of different polymeric solutions on a polystyrene plate lid. Among the various tested polymers, hydroxypropylcellulose at low and medium molecular weight (HPC) and pectin at two different degrees of esterification (PC) were chosen for preparing solutions with good casting properties, capable of producing films suitable for mucosal application.Results and discussion: The obtained films showed excellent drug content uniformity and stability and rapid drug release, which, at 8?min, ranged from 60% to 80%. All films presented satisfactory mucoadhesive and mechanical properties, also confirmed by a test on healthy volunteers, who did not experience irritation or mucosa damages. Pectin films based on pectin at lower degrees of esterification have been further evaluated to study the influence of two different amounts of drug on the physicochemical properties of the formulation. A slight reduction in elasticity has been observed in films containing a higher drug dose; nevertheless, the formulation maintained satisfactory flexibility and resistance to elongation.Conclusions: HPC and PC sublingual films, obtained by a simple casting method, could be proposed to realize personalized hospital pharmacy preparations on a small scale. 相似文献
39.
Integration of biofuels intermediates production and nutrients recycling in the processing of a marine algae 总被引:1,自引:0,他引:1
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Ali Teymouri Sandeep Kumar Elena Barbera Eleonora Sforza Alberto Bertucco Tomas Morosinotto 《American Institute of Chemical Engineers》2017,63(5):1494-1502
The cost‐effective production of liquid biofuels from microalgae is limited by several factors such as recovery of the lipid fractions as well as nutrients management. Flash hydrolysis, a rapid hydrothermal process, has been successfully applied to fractionate the microalgal biomass into solid biofuels intermediates while recovering a large amount of the nutrients in the aqueous phase (hydrolyzate) in a continuous flow reactor. The aim of the work is to enhance the quality of a high‐ash containing marine algae Nannochloropsis gaditana as biofuel feedstock while recycling nutrients directly for algae cultivation. Characterization of products demonstrated an increase in extractable lipids from 33.5 to 65.5 wt % (dry basis) while retaining the same fatty acid methyl ester profile, in addition to diminution of more than 70 wt % of ash compared to raw microalgae. Moreover, the hydrolyzate was directly used to grow a microalga of the same genus. © 2016 American Institute of Chemical Engineers AIChE J, 63: 1494–1502, 2017 相似文献
40.
Carolina Mariana Nunes Rafael Pissinatti Eleonora Vieira dos Santos Roberto Gonçalves Junqueira Scheilla Vitorino Carvalho de Souza 《Food Analytical Methods》2018,11(3):808-823
The presence of dibenzo-p-dioxins, polychlorinated dibenzofurans, and polychlorinated biphenyls in food is an important consideration for food safety, especially in fish matrices that are susceptible to bioaccumulation of those compounds from marine environments. In this context, the production of a reference material (RM) for this analytical scope is of great importance for ensuring the reliability of the results generated by monitoring programs. A lyophilized material was produced by spiking tilapia fillets with 29 compounds, and the material was evaluated based on the potential for using it as a certified reference material (CRM) or in proficiency testing (PT) schemes. A pilot experiment was performed to evaluate the incorporation of the analytes in tilapia fillets using standards prepared in nonane and in fish oil. The process yield was approximately 16% for both conditions, but higher mean recoveries were achieved with fish oil. The tilapia fillets were processed, and a portion of this bulk was spiked and then homogenized. The spiked and unspiked portions were frozen prior to lyophilization. Each freeze-dried portion was homogenized and sieved, and then, the portions were mixed, packed, and stored under refrigeration. The material was considered homogeneous for all analytes based on the criteria established for PT. Of the tested analytes, 27 were found to be stable in the short-term design (p > 0.05) when the material was kept at 45 ± 2 °C for 9 days. Long-term stability was evaluated at 2, 4, 6, and 8 months, and 22 of the analytes were found to be stable through up to 4 months of storage based on the criteria defined in references related to both the production of CRM and PT. The contributions of the homogeneity and stability in the short- and long-term uncertainties were estimated and indicated the adequacy of the material for use as a reference for trueness experiments. 相似文献