Angiogenesis and Anti-Angiogenic Treatment in Prostate Cancer: Mechanisms of Action and Molecular Targets

Prostate cancer (PC) is the most common cancer in men and the second leading cause of cancer-related death worldwide. Many therapeutic advances over the last two decades have led to an improvement in the survival of patients with metastatic PC, yet the majority of these patients still succumb to their disease. Antiagiogenic therapies have shown substantial benefits for many types of cancer but only a marginal benefit for PC. Ongoing clinical trials investigate antiangiogenic monotherapies or combination therapies. Despite the important role of angiogenesis in PC, clinical trials in refractory castration-resistant PC (CRPC) have demonstrated increased toxicity with no clinical benefit. A better understanding of the mechanism of angiogenesis may help to understand the failure of trials, possibly leading to the development of new targeted anti-angiogenic therapies in PC. These could include the identification of specific subsets of patients who might benefit from these therapeutic strategies. This paper provides a comprehensive review of the pathways involved in the angiogenesis, the chemotherapeutic agents with antiangiogenic activity, the available studies on anti-angiogenic agents and the potential mechanisms of resistance.     

Bibliography of literature on reliability in automotive industries

This paper presents a brief introduction and selective up-to-date references related to automotive reliability.     

Simulation and wake analysis of a single vertical axis wind turbine

Because of several design advantages and operational characteristics, particularly in offshore farms, vertical axis wind turbines (VAWTs) are being reconsidered as a complementary technology to horizontal axial turbines. However, considerable gaps remain in our understanding of VAWT performance since cross‐flow rotor configurations have been significantly less studied than axial turbines. This study examines the wakes of VAWTs and how their evolution is influenced by turbine design parameters. An actuator line model is implemented in an atmospheric boundary layer large eddy simulation code, with offline coupling to a high‐resolution blade‐scale unsteady Reynolds‐averaged Navier–Stokes model. The large eddy simulation captures the turbine‐to‐farm scale dynamics, while the unsteady Reynolds‐averaged Navier–Stokes captures the blade‐to‐turbine scale flow. The simulation results are found to be in good agreement with three existing experimental datasets. Subsequently, a parametric study of the flow over an isolated VAWT, carried out by varying solidities, height‐to‐diameter aspect ratios and tip speed ratios, is conducted. The analyses of the wake area and velocity and power deficits yield an improved understanding of the downstream evolution of VAWT wakes, which in turn enables a more informed selection of turbine designs for wind farms. Copyright © 2016 John Wiley & Sons, Ltd.     

A non-Newtonian model based on Ree-Eyring theory and surface effect to predict friction in elastohydrodynamic lubrication

The traction behaviour of various lubricants is investigated in elastohydrodynamic regime using a tribometre that simultaneously allows the contact visualization and the friction measurement under controlled contact kinematics. First, the film formation capability is determined: although the base oil and the polymer, via their viscosity, govern the film thickness in EHL regime, the additives control the existence of a boundary film at low entrainment speed. Second, the relative role of the additives and of the base oil on the frictional behaviour is studied for various experimental conditions: this clearly demonstrates that the piezo-viscous response of the lubricant controls the Newtonian/non-Newtonian transition and the friction level. The role of thermal effects is discussed. A strong influence of the entrainment speed, over the frictional response is unexpectedly observed, even in full film regime. A rheological model based on Ree-Eyring theory supposing a heterogeneous flow due to adsorbed surface layers, is proposed to discuss the organization of the molecules within the contact and its effect on the frictional response of the contact.     

Donor‐Stabilized Phosphenium Adducts as New Efficient and Immobilizing Ligands in Palladium‐Catalyzed Alkynylation and Platinum‐Catalyzed Hydrogenation in Ionic Liquids

The straightforward synthesis of a new donor‐stabilized phosphenium ligand 3d by addition of bromodifurylphosphine to 1,3‐dimethylimidazolium‐2‐carboxylate 1 is described. The obtained ligand exhibits a very strong π‐acceptor character, comparable to that of triphenyl phosphite [P(OPh)₃] or of tris‐halogenophosphines, with a ν_CO(A₁) at 2087 cm⁻¹ for its nickel tricarbonyl complex. This ligand, as well as the related 3a which was obtained from chlorodiphenylphosphine, were tested in palladium‐catalyzed aryl alkynylation and in the platinum‐catalyzed selective hydrogenation of chloronitrobenzenes, both in an ionic liquid phase. In C C bond cross‐coupling we observed that the increase of the π‐acceptor character in ligand 3d , due to the introduction of an additional electron‐withdrawing group, provides a very efficient catalyst in the alkynylation reaction of aryl bromides with phenylacetylene, including the deactivated 4‐bromoanisole or the sterically hindered 2‐bromonaphthalene. The catalytic activity decreases with recycling due to the sensitiveness of ligands to protonation in the ionic phase. Conversely, a multiple recycling of the metal/ligand system in non‐acidic media was achieved from platinum‐catalyzed hydrogenation of m‐chloronitrobenzene. The catalytic results obtained by employing the complex of platinum(II) chloride with 3a [trans‐PtCl₂( 3a )₂] in comparison with the non‐ionic related trans‐tris(triphenylphosphine)platinum dichloride [trans‐PtCl₂(PPh₃)₂] complex clearly indicate that the simultaneous existence of a strong π‐acceptor character and a positive charge within the ligand 3a significantly increases the life‐time of the platinum catalyst. The selectivity of the reaction is also improved by decreasing the undesirable formation of dehalogenation products. This cationic platinum complex trans‐PtCl₂( 3a )₂ is the first example of a highly selective catalyst for hydrogenation of chloronitroarenes immobilized in an ionic liquid phase. The system was recycled six times without noticeable metal leaching in the organic phase, and no loss of activity.     

Rapid identification of Candida species with species-specific DNA probes

Rapid identification of Candida species has become more important because of an increase in infections caused by species other than Candida albicans, including species innately resistant to azole antifungal drugs. We previously developed a PCR assay with an enzyme immunoassay (EIA) format to detect amplicons from the five most common Candida species by using universal fungal primers and species-specific probes directed to the ITS2 region of the gene for rRNA. We designed probes to detect seven additional Candida species (C. guilliermondii, C. kefyr, C. lambica, C. lusitaniae, C. pelliculosa, C. rugosa, and C. zeylanoides) included in the API 20C sugar assimilation panel, five probes for species not identified by API 20C (C. haemulonii, C. norvegica, C. norvegensis, C. utilis, and C. viswanathii), and a probe for the newly described species C. dubliniensis, creating a panel of 18 Candida species probes. The PCR-EIA correctly identified multiple strains of each species tested, including five identified as C. albicans by the currently available API 20C database but determined to be C. dubliniensis by genotypic and nonroutine phenotypic characteristics. Species identification time was reduced from a mean of 3.5 days by conventional identification methods to 7 h by the PCR-EIA. This method is simple, rapid, and feasible for identifying Candida species in clinical laboratories that utilize molecular identification techniques and provides a novel method to differentiate the new species, C. dubliniensis, from C. albicans.     

Dégradation des eaux de rejets issues d’une raffinerie d’huile de coton par plasma d’arc électrique rampant à pression atmosphérique

Wastewater samples from liquid effluents of cotton oil refinery in Far-Northern Cameroon were exposed to a gliding arc discharge for various exposure times in a cold plasma reactor. The analysed results showed high levels of organic pollution parameters (TOC = 4635 mg/L, COD = 6943, 98 mg/L) before treatment. More than 56% TOC and 75% COD abatement were obtained after 30 min treatment in batch conditions with a laboratory reactor. The resultant pollution abatement is attributed both to strong oxidizing effects of °OH and NO° radicals formed in the plasma and their derivatives (H₂O₂, ONO₂H and NO₃H). The conductivity and TDS increase linearly and the pH, TOC and COD decrease with increasing exposure time to the discharge. The oxidation obeys a pseudo first-order kinetics law (kinetic rate: k_1DCO = 0, 0381 min^?1 and k_1COT = 0, 0245 min^?1).     

Effects of water–cement solutions on the composition of organic compounds leached from oxidized Callovo–Oxfordian argillaceous sediment

Both oxygen penetration, due to excavation, and the use of hydraulic cement as engineering barrier has led to the investigation of effects of high pH solutions on the oxidized host rock formation. A Callovo–Oxfordian sediment has been oxidized in a ventilated drying oven at 130 °C between 2 and 1024 h. The geochemical characterization of oxidized samples shows that oxidation induces transformations in extractable organic matter similar to those observed during thermal maturation. Rock-Eval analyses of extracted solid residues reveal a loss of hydrogen while oxygen is incorporated into the kerogen structure during oxidation experiments. The oxidized samples have been leached with deionized water and cement solution. Comparisons between basic and near-neutral leaching treatments showed that the amounts and nature of leached organic species are pH-dependent. The dissolved organic compound amounts are higher at basic pH than at pH close to neutrality. Gas chromatography–mass spectrometry (GC-MS) analyses show that aromatic carboxylic acids are preferentially leached by deionized water, while n-carboxylic acids predominate in cementitious solution. The data reveal that kerogen oxygen content may constrain the dissolved concentration of organic species. The DOC concentration and the C=O functionality of leachable organic molecules increase with increasing duration of oxidation.     

The Lithium/Air Battery: Still an Emerging System or a Practical Reality?

Lithium/air is a fascinating energy storage system. The effective exploitation of air as a battery electrode has been the long‐time dream of the battery community. Air is, in principle, a no‐cost material characterized by a very high specific capacity value. In the particular case of the lithium/air system, energy levels approaching that of gasoline have been postulated. It is then not surprising that, in the course of the last decade, great attention has been devoted to this battery by various top academic and industrial laboratories worldwide. This intense investigation, however, has soon highlighted a series of issues that prevent a rapid development of the Li/air electrochemical system. Although several breakthroughs have been achieved recently, the question on whether this battery will have an effective economic and societal impact remains. In this review, a critical evaluation of the progress achieved so far is made, together with an attempt to propose future R&D trends. A forecast on whether Li/air may have a role in the next years' battery technology is also postulated.