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11.
Elisabetta Gavini Giovanna Rassu Giuseppina Sandri Silvia Rossi Andrea Salis 《Drug development and industrial pharmacy》2016,42(4):554-562
AbstractCiprofloxacin is a drug active against a broad spectrum of aerobic Gram-positive and Gram-negative bacteria, for the therapy of ocular infections. It requires frequent administrations owing to rapid ocular clearance and it is a good candidate for ocular controlled release formulations. The preparation of such drug release systems is still a challenge. Ionic interactions between ciprofloxacin and the polyelectrolytes chondroitin sulfate or lambda carrageenan result in coprecipitates that can act as microparticulate controlled release systems from which the drug is released after being displaced by the medium’s ions. In some formulations, Carbopol was added to improve the mucoadhesive properties. The aim of this research was the study of the influence of the technological parameters of the preparation method of coprecipitates on their particle size, with the goal of achieving particles engineered with a size suitable for the ocular administration. Technological parameters taken into account were: concentration of drug and polymer solutions utilized for the preparation of interaction products, possible use of surfactants (kind and concentration), temperature of the solutions and stirring during the process of preparation of the coprecipitates. Preliminary stability study tests were carried out to further characterize the leader formulation. Particle size in suspensions for ocular drug delivery is a critical parameter influencing the quality of the formulation. The results obtained from this study show that chondroitin sulfate coprecipitates present the best characteristics in terms of particle size suitable for ocular administration. A further improvement of the particle size characteristics has been obtained with the addition of surfactants. 相似文献
12.
Interfacing human and computer with wireless body area sensor networks: the WiMoCA solution 总被引:1,自引:0,他引:1
Elisabetta Farella Augusto Pieracci Luca Benini Laura Rocchi Andrea Acquaviva 《Multimedia Tools and Applications》2008,38(3):337-363
Wireless Body Area Sensor Networks (WBASN) are an emerging technology enabling the design of natural human–computer interfaces
(HCI). Automatic recognition of human motion, gestures, and activities is studied in several contexts. For example, mobile
computing technology is being considered as a replacement of traditional input systems. Moreover, body posture and activity
monitoring can be used for entertainment and health-care applications. However, until now, little work has been done to develop
flexible and efficient WBASN solutions suitable for a wide range of applications. Their requirements pose new challenges for
sensor network designs, such as optimizing traditional solutions for use as environmental monitoring-like applications and
developing on-the-field stress tests. In this paper, we demonstrate the flexibility of a custom-designed WBASN called WiMoCA
with respect to a wide range of posture and activity recognition applications by means of practical implementation and on-the-field
testing. Nodes of the network mounted on different parts of the human body exploit tri-axial accelerometers to detect its
movements. The advanced digital Micro-electro-mechanical system (MEMS) based inertial sensor has been chosen for WiMoCA because
it demonstrated high flexibility of use in many different situations, providing the chance to exploit both static and dynamic
acceleration components for different purposes. Furthermore, the sensibility and accuracy of the sensing element is perfectly
adequate for monitoring human movement, while keeping cost low and size compact, thus meeting our requirements. We implemented
three types of applications, stressing the WBASN in many aspects. In fact, they are characterized by different requirements
in terms of accuracy, timeliness, and computation distributed on sensing nodes. For each application, we describe its implementation,
and we discuss results about performance and power consumption.
相似文献
Andrea AcquavivaEmail: |
13.
Cappiello A Famiglini G Palma P Pierini E Termopoli V Trufelli H 《Mass spectrometry reviews》2011,30(6):1242-1255
This review article will give an up-to-date and exhaustive overview on the efficient use of electron ionization (EI) to couple liquid chromatography and mass spectrometry (LC-MS) with an innovative interface called Direct-EI. EI is based on the gas-phase ionization of the analytes, and it is suitable for many applications in a wide range of LC-amenable compounds. In addition, thanks to its operating principles, it prevents unwelcome matrix effects (ME). In fact, although atmospheric pressure ionization (API) methodologies have boosted the use of LC-MS, the related analytical methods are sometime affected by inaccurate quantitative results, due to unavoidable and unpredictable ME. In addition, API's soft ionization spectra always demand for costly and complex tandem mass spectrometry (MS/MS) instruments, which are essential to acquire an "information-rich" spectrum and to obtain accurate quantitative information. In EI a one-stage analyzer is sufficient for a qualitative investigation and MS/MS detection is only used to improve sensitivity and to cut chemical noise. The technology illustrated here provides a robust and straightforward access to classical, well-characterized EI data for a variety of LC applications, and readily interpretable spectra for a wide range of areas of research. The Direct-EI interface can represent the basis for a forthcoming universal LC-MS detector for small molecules. 相似文献
14.
15.
Fortuna Iannuzzo Vincenzo Piccolo Ettore Novellino Elisabetta Schiano Emanuela Salviati Vincenzo Summa Pietro Campiglia Gian Carlo Tenore Maria Maisto 《International journal of molecular sciences》2022,23(21)
Proanthocyanidins (PACs) are a group of bioactive molecules found in a variety of plants and foods. Their bioavailability depends on their molecular size, with monomers and dimers being more bioavailable than those that have a higher polymerization degree. This study aimed to develop a method to convert high-molecular-weight PACs to low-molecular-weight ones in a grape seed extract (GSE) from Vitis vinifera L. Therefore, GSE was subjected to alkaline treatment (ATGSE), and its difference in chemical composition, compared to GSE, was evaluated using a molecular networking (MN) approach based on results obtained from HPLC-ESI HRMS/MS characterization analysis. The network analysis mainly noted the PAC cluster with about 142 PAC compounds identified. In particular, the obtained results showed a higher content of monomeric and dimeric PACs in ATGSE compared to GSE, with 58% and 49% monomers and 31% and 24% dimers, respectively. Conversely, trimeric (9%), polymeric (4%), and galloylated PACs (14%) were more abundant in GSE than in ATGSE (6%, 1%, and 4%, respectively). Moreover, in vitro antioxidant and anti-inflammatory activities were investigated, showing the high beneficial potential of both extracts. In conclusion, ATGSE could represent an innovative natural matrix rich in bioavailable and bioaccessible PACs for nutraceutical applications with potential beneficial properties. 相似文献
16.
Maria Vliora Eleni Nintou Eleni Karligiotou Leonidas G. Ioannou Elisabetta Grillo Stefania Mitola Andreas D. Flouris 《International journal of molecular sciences》2022,23(17)
Cancer is a set of diseases characterized by several hallmark properties, such as increased angiogenesis, proliferation, invasion, and metastasis. The increased angiogenic activity constantly supplies the tumors with nutrients and a plethora of cytokines to ensure cell survival. Along these cytokines is a newly discovered protein, called irisin, which is released into the circulation after physical exercise. Irisin is the product of fibronectin type III domain-containing protein 5 (FNDC5) proteolytic cleavage. Recently it has been the topic of investigation in several types of cancer. In this study, we conducted a systematic review and meta-analysis to investigate its implication in different types of cancer. Our results suggest that irisin expression is decreased in cancer patients, thus it can be used as a valid biomarker for the diagnosis of several types of cancer. In addition, our results indicate that irisin may have an important role in tumor progression and metastasis since it is involved in multiple signaling pathways that promote cell proliferation and migration. 相似文献
17.
A polyhedral decomposition can be unambiguously described as the collection of four primitive elements (i.e., polyhedra, facets, edges, and vertices) plus their mutual adjacency relations. We consider here the problem of representing a specific kind of polyhedral decomposition, i.e., a tetrahedralization. We describe two different representations for a tetrahedralization. The first one can only model polyhedral decompositions with tetrahedral cells, while the second one is suitable for describing any partition of a volume into polyhedral cells with triangular facets. We present two sets of primitive Euler operators, which build and manipulate such representations while maintaining their topological integrity. The use of such operators is demonstrated in connection with two algorithms for building a Delaunay tetrahedralization, which show the different hedralization, which show the different uses of the two representations. 相似文献
18.
19.
Elisabetta Murru Anna Lisa Muntoni Claudia Manca Sonia Aroni Marco Pistis Sebastiano Banni Gianfranca Carta 《International journal of molecular sciences》2023,24(1)
Fenofibrate (FBR), an oral medication used to treat dyslipidemia, is a ligand of the peroxisome proliferator-activated receptor α (PPARα), a nuclear receptor that regulates the expression of metabolic genes able to control lipid metabolism and food intake. PPARα natural ligands include fatty acids (FA) and FA derivatives such as palmitoylethanolamide (PEA) and oleoylethanolamide (OEA), known to have anti-inflammatory and anorexigenic activities, respectively. We investigated changes in the FA profile and FA derivatives by HPLC and LC-MS in male C57BL/6J mice fed a standard diet with or without 0.2% fenofibrate (0.2% FBR) for 21 days. Induction of PPARα by 0.2% FBR reduced weight gain, food intake, feed efficiency, and liver lipids and induced a profound change in FA metabolism mediated by parallel enhanced mitochondrial and peroxisomal β-oxidation. The former effects led to a steep reduction of essential FA, particularly 18:3n3, with a consequent decrease of the n3-highly unsaturated fatty acids (HUFA) score; the latter effect led to an increase of 16:1n7 and 18:1n9, suggesting enhanced hepatic de novo lipogenesis with increased levels of hepatic PEA and OEA, which may activate a positive feedback and further sustain reductions of body weight, hepatic lipids and feed efficiency. 相似文献
20.
Giulia Gizzi Samuela Cataldi Claudia Mazzeschi Elisa Delvecchio Maria Rachele Ceccarini Michela Codini Elisabetta Albi 《International journal of molecular sciences》2022,23(13)
The relationship between cholesterol and cancer has been widely demonstrated. Clinical studies have shown changes in blood cholesterol levels in cancer patients. In parallel, basic research studies have shown that cholesterol is involved in the mechanisms of onset and progression of the disease. On the other hand, anorexic patients have high cholesterol levels and a high susceptibility to cancer. In this review, we first present a brief background on the relations among nutrition, eating disorders and cancer. Using several notable examples, we then illustrate the changes in cholesterol in cancer and in anorexia nervosa, providing evidence for their important relationship. Finally, we show a new possible link between cholesterol disorder in cancer and in anorexia nervosa. 相似文献