全文获取类型
收费全文 | 570篇 |
免费 | 26篇 |
专业分类
电工技术 | 3篇 |
化学工业 | 265篇 |
金属工艺 | 7篇 |
机械仪表 | 18篇 |
建筑科学 | 11篇 |
矿业工程 | 1篇 |
能源动力 | 14篇 |
轻工业 | 110篇 |
石油天然气 | 1篇 |
无线电 | 11篇 |
一般工业技术 | 81篇 |
冶金工业 | 18篇 |
原子能技术 | 1篇 |
自动化技术 | 55篇 |
出版年
2023年 | 10篇 |
2022年 | 58篇 |
2021年 | 59篇 |
2020年 | 18篇 |
2019年 | 18篇 |
2018年 | 13篇 |
2017年 | 16篇 |
2016年 | 18篇 |
2015年 | 16篇 |
2014年 | 18篇 |
2013年 | 42篇 |
2012年 | 33篇 |
2011年 | 41篇 |
2010年 | 36篇 |
2009年 | 32篇 |
2008年 | 42篇 |
2007年 | 21篇 |
2006年 | 17篇 |
2005年 | 17篇 |
2004年 | 12篇 |
2003年 | 3篇 |
2002年 | 6篇 |
2001年 | 7篇 |
2000年 | 8篇 |
1999年 | 5篇 |
1998年 | 4篇 |
1997年 | 1篇 |
1996年 | 3篇 |
1995年 | 4篇 |
1994年 | 4篇 |
1992年 | 4篇 |
1990年 | 5篇 |
1989年 | 1篇 |
1985年 | 2篇 |
1984年 | 1篇 |
1983年 | 1篇 |
排序方式: 共有596条查询结果,搜索用时 15 毫秒
131.
132.
Giulia Gizzi Samuela Cataldi Claudia Mazzeschi Elisa Delvecchio Maria Rachele Ceccarini Michela Codini Elisabetta Albi 《International journal of molecular sciences》2022,23(13)
The relationship between cholesterol and cancer has been widely demonstrated. Clinical studies have shown changes in blood cholesterol levels in cancer patients. In parallel, basic research studies have shown that cholesterol is involved in the mechanisms of onset and progression of the disease. On the other hand, anorexic patients have high cholesterol levels and a high susceptibility to cancer. In this review, we first present a brief background on the relations among nutrition, eating disorders and cancer. Using several notable examples, we then illustrate the changes in cholesterol in cancer and in anorexia nervosa, providing evidence for their important relationship. Finally, we show a new possible link between cholesterol disorder in cancer and in anorexia nervosa. 相似文献
133.
Elisabetta Macerola Agnese Proietti Anello Marcello Poma Paola Vignali Rebecca Sparavelli Alessandro Ginori Alessio Basolo Rossella Elisei Ferruccio Santini Fulvio Basolo 《International journal of molecular sciences》2022,23(13)
Patients with advanced thyroid cancer harboring NTRK rearrangements can be treated with highly effective selective inhibitors. Immunohistochemistry (IHC) analysis, to detect Trk protein expression, represents an appealing screening strategy for NTRK rearrangements, but its efficacy has been poorly explored in thyroid cancer. The aim of this study is to investigate the diagnostic utility of Trk IHC in the identification of NTRK rearrangements. A series of 26 follicular-derived thyroid tumors, positive for NTRK rearrangements, and 28 NTRK fusion-negative controls were retrospectively analyzed by IHC using the pan-Trk monoclonal antibody (clone ) on the Ventana system. Area under the curve (AUC), sensitivity and specificity were calculated by ROC analysis. Trk expression was detected in 25 samples, including 22 out of the 26 NTRK-rearranged (84.6%) and three out of 28 NTRK-negative samples (10.7%). Four out of twenty-six NTRK-rearranged thyroid tumors were negative for Trk expression (15.4%), all carrying the ETV6/NTRK3 fusion. The AUC, sensitivity and specificity were 0.87, 0.85 and 0.89, respectively. A screening based on IHC analysis showed limited sensitivity and specificity in the identification of NTRK-rearranged tumors. Since falsely negative results could preclude the administration of effective targeted drugs, alternative detection strategies should be considered for thyroid cancer. EPR17341相似文献
134.
135.
Fortuna Iannuzzo Vincenzo Piccolo Ettore Novellino Elisabetta Schiano Emanuela Salviati Vincenzo Summa Pietro Campiglia Gian Carlo Tenore Maria Maisto 《International journal of molecular sciences》2022,23(21)
Proanthocyanidins (PACs) are a group of bioactive molecules found in a variety of plants and foods. Their bioavailability depends on their molecular size, with monomers and dimers being more bioavailable than those that have a higher polymerization degree. This study aimed to develop a method to convert high-molecular-weight PACs to low-molecular-weight ones in a grape seed extract (GSE) from Vitis vinifera L. Therefore, GSE was subjected to alkaline treatment (ATGSE), and its difference in chemical composition, compared to GSE, was evaluated using a molecular networking (MN) approach based on results obtained from HPLC-ESI HRMS/MS characterization analysis. The network analysis mainly noted the PAC cluster with about 142 PAC compounds identified. In particular, the obtained results showed a higher content of monomeric and dimeric PACs in ATGSE compared to GSE, with 58% and 49% monomers and 31% and 24% dimers, respectively. Conversely, trimeric (9%), polymeric (4%), and galloylated PACs (14%) were more abundant in GSE than in ATGSE (6%, 1%, and 4%, respectively). Moreover, in vitro antioxidant and anti-inflammatory activities were investigated, showing the high beneficial potential of both extracts. In conclusion, ATGSE could represent an innovative natural matrix rich in bioavailable and bioaccessible PACs for nutraceutical applications with potential beneficial properties. 相似文献
136.
Elisabetta Murru Anna Lisa Muntoni Claudia Manca Sonia Aroni Marco Pistis Sebastiano Banni Gianfranca Carta 《International journal of molecular sciences》2023,24(1)
Fenofibrate (FBR), an oral medication used to treat dyslipidemia, is a ligand of the peroxisome proliferator-activated receptor α (PPARα), a nuclear receptor that regulates the expression of metabolic genes able to control lipid metabolism and food intake. PPARα natural ligands include fatty acids (FA) and FA derivatives such as palmitoylethanolamide (PEA) and oleoylethanolamide (OEA), known to have anti-inflammatory and anorexigenic activities, respectively. We investigated changes in the FA profile and FA derivatives by HPLC and LC-MS in male C57BL/6J mice fed a standard diet with or without 0.2% fenofibrate (0.2% FBR) for 21 days. Induction of PPARα by 0.2% FBR reduced weight gain, food intake, feed efficiency, and liver lipids and induced a profound change in FA metabolism mediated by parallel enhanced mitochondrial and peroxisomal β-oxidation. The former effects led to a steep reduction of essential FA, particularly 18:3n3, with a consequent decrease of the n3-highly unsaturated fatty acids (HUFA) score; the latter effect led to an increase of 16:1n7 and 18:1n9, suggesting enhanced hepatic de novo lipogenesis with increased levels of hepatic PEA and OEA, which may activate a positive feedback and further sustain reductions of body weight, hepatic lipids and feed efficiency. 相似文献
137.
Maria Vliora Eleni Nintou Eleni Karligiotou Leonidas G. Ioannou Elisabetta Grillo Stefania Mitola Andreas D. Flouris 《International journal of molecular sciences》2022,23(17)
Cancer is a set of diseases characterized by several hallmark properties, such as increased angiogenesis, proliferation, invasion, and metastasis. The increased angiogenic activity constantly supplies the tumors with nutrients and a plethora of cytokines to ensure cell survival. Along these cytokines is a newly discovered protein, called irisin, which is released into the circulation after physical exercise. Irisin is the product of fibronectin type III domain-containing protein 5 (FNDC5) proteolytic cleavage. Recently it has been the topic of investigation in several types of cancer. In this study, we conducted a systematic review and meta-analysis to investigate its implication in different types of cancer. Our results suggest that irisin expression is decreased in cancer patients, thus it can be used as a valid biomarker for the diagnosis of several types of cancer. In addition, our results indicate that irisin may have an important role in tumor progression and metastasis since it is involved in multiple signaling pathways that promote cell proliferation and migration. 相似文献
138.
139.
Dr. Elisabetta Buommino Prof. Alfonso Carotenuto Dr. Ignazio Antignano Dr. Rosa Bellavita Dr. Bruno Casciaro Dr. Maria Rosa Loffredo Dr. Francesco Merlino Prof. Ettore Novellino Prof. Maria Luisa Mangoni Dr. Francesca Paola Nocera Dr. Diego Brancaccio Dr. Pasqualina Punzi Dr. Daniela Roversi Dr. Raffaele Ingenito Dr. Elisabetta Bianchi Prof. Paolo Grieco 《ChemMedChem》2019,14(13):1283-1290
Previously, we identified a potent antimicrobial analogue of temporin L (TL), [Pro3]TL, in which glutamine at position 3 was substituted with proline. In this study, a series of analogues in which position 3 is substituted with non-natural proline derivatives, was investigated for correlations between the conformational properties of the compounds and their antibacterial, cytotoxic, and hemolytic activities. Non-natural proline analogues with substituents at position 4 of the pyrrolidine ring were considered. Structure–activity relationship (SAR) studies of these analogues were performed by means of antimicrobial and cytotoxicity assays along with circular dichroism (CD) and NMR spectroscopic analyses for selected compounds. The most promising peptides were additionally evaluated for their activity against some representative veterinary microbial strains to compare with those from human strains. We identified novel analogues with interesting properties that make them attractive lead compounds. 相似文献
140.
Bonaventura Luca Calzola Elisa Carlini Elisabetta Ferretti Roberto 《Journal of scientific computing》2021,88(1):1-22
Journal of Scientific Computing - We analyse numerically the periodic problem and the initial boundary value problem of the Korteweg-de Vries equation and the Drindfeld–Sokolov–Wilson... 相似文献