全文获取类型
收费全文 | 627篇 |
免费 | 26篇 |
专业分类
电工技术 | 3篇 |
化学工业 | 283篇 |
金属工艺 | 7篇 |
机械仪表 | 21篇 |
建筑科学 | 13篇 |
矿业工程 | 1篇 |
能源动力 | 17篇 |
轻工业 | 110篇 |
石油天然气 | 1篇 |
无线电 | 13篇 |
一般工业技术 | 91篇 |
冶金工业 | 34篇 |
原子能技术 | 1篇 |
自动化技术 | 58篇 |
出版年
2023年 | 10篇 |
2022年 | 60篇 |
2021年 | 62篇 |
2020年 | 20篇 |
2019年 | 19篇 |
2018年 | 13篇 |
2017年 | 18篇 |
2016年 | 20篇 |
2015年 | 18篇 |
2014年 | 20篇 |
2013年 | 49篇 |
2012年 | 34篇 |
2011年 | 46篇 |
2010年 | 37篇 |
2009年 | 33篇 |
2008年 | 43篇 |
2007年 | 24篇 |
2006年 | 19篇 |
2005年 | 17篇 |
2004年 | 12篇 |
2003年 | 3篇 |
2002年 | 6篇 |
2001年 | 8篇 |
2000年 | 8篇 |
1999年 | 5篇 |
1998年 | 9篇 |
1997年 | 6篇 |
1996年 | 3篇 |
1995年 | 6篇 |
1994年 | 5篇 |
1993年 | 1篇 |
1992年 | 3篇 |
1991年 | 2篇 |
1990年 | 5篇 |
1989年 | 1篇 |
1985年 | 3篇 |
1984年 | 1篇 |
1983年 | 1篇 |
1981年 | 2篇 |
1976年 | 1篇 |
排序方式: 共有653条查询结果,搜索用时 0 毫秒
41.
Elisabetta Fanizza Carmine Urso R. Maria Iacobazzi Nicoletta Depalo Michela Corricelli Annamaria Panniello 《Science and Technology of Advanced Materials》2016,17(1):98-108
Silica based multifunctional heterostructures, exhibiting near infrared (NIR) absorption (650–1200 nm) and luminescence in the visible region, represent innovative nanosystems useful for diagnostic or theranostic applications. Herein, colloidal synthetic procedures are applied to design a photoactive multifunctional nanosystem. Luminescent silica (SiO2) coated quantum dots (QDs) have been used as versatile nanoplatforms to assemble on their surface gold (Au) seeds, further grown into Au spackled structures. The synthesized nanostructures combine the QD emission in the visible region, and, concomitantly, the distinctive NIR absorption of Au nanodomains. The possibility of having multiple QDs in a single heterostructure, the SiO2 shell thickness, and the extent of Au deposition onto SiO2 surface have been carefully controlled. The work shows that a single QD entrapped in 16 nm thick SiO2 shell, coated with Au speckles, represents the most suitable geometry to preserve the QD emission in the visible region and to generate NIR absorption from metal NPs. The resulting architectures present a biomedical potential as an effective optical multimodal probes and as promising therapeutic agents due to the Au NP mediated photothermal effect. 相似文献
42.
Arianna Alfieri Marco Cantamessa Francesca Montagna Elisabetta Raguseo 《Computers & Industrial Engineering》2013,64(2):562-572
Production systems design is a multifaceted task, due to a variety of aspects such as the mutual interdependency between the sub-systems, the variety of configurations and alternative system control strategies, the multiple managerial and “soft” aspects that cast an influence on the behavior of the system. A reasonable number of modeling tools can be applied to production system design, but they tend to divide the problem into unconnected sub-problems whose individual solutions may result in a poor global one. This is despite the fact that production design encompasses all aspects of manufacturing operations, and needs a systemic approach, as clearly shown in practitioner-oriented literature. This paper proposes to apply the “System of Systems” approach to production system design in order to represent their main aspects and support the rational definition of the path leading from corporate strategy to system (re)design. 相似文献
43.
44.
Burn KW Casalini L Nava E Petrovich C Tecchio L 《Radiation protection dosimetry》2005,116(1-4 PT 2):89-94
The Study and Production of Exotic Species (SPES) project employs a 100 MeV, 30 mA proton beam that strikes a primary target. The resulting high-energy neutron flux impinges on a secondary target of depleted uranium to produce, through fission, beams of short-lived, neutron-rich nuclei. This paper deals with some of the preliminary shielding calculations for the bunker. Monte Carlo is employed with MCNPX and, because of the deep penetrations involved, the in-house variance reduction optimiser, the direct statistical approach. The calculations exhibited a number of typical features that are addressed and discussed. 相似文献
45.
Fabio Maria Sabbatini Dr. Romano Di Fabio Dr. Mauro Corsi Dr. Paolo Cavanni Dr. Steve M. Bromidge Dr. Yves St‐Denis Dr. Lucilla D'Adamo Dr. Marilisa Rinaldi Dr. Chiara Savoia Dr. Claudia Mundi Dr. Benedetta Perini Dr. Andrew J. Carpenter Dr. Giovanna Dal Forno Dr. Federico Faggioni Dr. Michela Tessari Dr. Francesca Pavone Dr. Alberto Buson Dr. Mario Mattioli Dr. Elisabetta Perdona' Dr. Sergio Melotto Dr. 《ChemMedChem》2010,5(9):1450-1455
46.
Giorgio Abbiati Fabio Marinelli Elisabetta Rossi Antonio Arcadi 《Israel journal of chemistry》2013,53(11-12):856-868
The peculiar features of gold(III) and gold(I) species include exceptional carbophilicity and, at the same time, lone pair affinity. Such a combination offers many advantages for the development of more sustainable approaches to the synthesis of indole derivatives from readily available 2-alkynylanilines. This mini-review critically summarizes the literature reports in this field, with the aim to encourage further research activities in this promising area. 相似文献
47.
Sara Salucci Sabrina Burattini Michela Battistelli Valentina Baldassarri Maria Cristina Maltarello Elisabetta Falcieri 《International journal of molecular sciences》2013,14(1):532-546
Ultraviolet B (UVB) radiation acts as a strong apoptotic trigger in many cell types, in tumor and normal cells. Several studies have demonstrated that UVB-induced cell death occurs through the generation of reactive oxygen species. The consequent oxidative stress includes the impairment of cellular antioxidants, the induction of DNA damage and the occurrence of apoptosis. In this review, we investigated UVB apoptotic action in various cell models by using ultrastructural, molecular and cytofluorimetric techniques. Myeloid leukemia HL-60, T-lymphoblastoid Molt-4 and myelomonocytic U937 human cells, generally affected by apoptotic stimuli, were studied. Human chondrocytes and C2C12 skeletal muscle cells, known to be more resistant to damage, were also considered. All of them, when exposed to UVB radiation, revealed a number of characteristic apoptotic markers. Membrane blebbing, cytoplasm shrinkage and chromatin condensation were detected by means of electron microscopy. DNA cleavage, investigated by using agarose gel electrophoresis and TUNEL reaction, was observed in suspended cells. Differently, in chondrocytes and in skeletal muscle cells, oligonucleosomic DNA fragmentation did not appear, even if a certain TUNEL positivity was detected. These findings demonstrate that UVB radiation appears to be an ideal tool to study the apoptotic behavior. 相似文献
48.
49.
Francesca Mainini Alessandro Contini Donatella Nava Paola Antonia Corsetto Angela Maria Rizzo Elisabetta Agradi Elena Pini 《Journal of the American Oil Chemists' Society》2013,90(11):1751-1759
Quercetin shows interesting pharmacological effects, but its use in topical applications is limited by its low skin permeability and solubility. In this work, the synthesis of highly lipophilic quercetin esters with oleic, linoleic and linolenic acid useful as topical quercetin prodrugs is reported. Partial OH esterification is advisable to maintain the antioxidant activity of these compounds; tetraesters and triesters can be achieved by modulating the reaction conditions utilized for the total esterification of quercetin. The chemical structures of the esters were proven by spectroscopic techniques; quantum chemical NMR calculation were mandatory to unequivocally assign the free position in triesters. Finally, the antioxidant activity of all the synthesized compounds was determined by the 2,2-diphenyl-1-picryl-hydrazyl method and by 2,2-azinobis(3-ethyl-benzothiazoline-6-sulfonic acid) assay. 相似文献
50.
Elisabetta Albi Giuseppina Perrella Andrea Lazzarini Samuela Cataldi Remo Lazzarini Alessandro Floridi Francesco Saverio Ambesi-Impiombato Francesco Curcio 《International journal of molecular sciences》2014,15(7):11555-11565
Proliferating thyroid cells are more sensitive to UV-C radiations than quiescent cells. The effect is mediated by nuclear phosphatidylcholine and sphingomyelin metabolism. It was demonstrated that proton beams arrest cell growth and stimulate apoptosis but until now there have been no indications in the literature about their possible mechanism of action. Here we studied the effect of protons on FRTL-5 cells in culture. We showed that proton beams stimulate slightly nuclear neutral sphingomyelinase activity and inhibit nuclear sphingomyelin-synthase activity in quiescent cells whereas stimulate strongly nuclear neutral sphingomyelinase activity and do not change nuclear sphingomyelin-synthase activity in proliferating cells. The study of neutral sphingomyelinase/sphingomyelin-synthase ratio, a marker of functional state of the cells, indicated that proton beams induce FRTL-5 cells in a proapoptotic state if the cells are quiescent and in an initial apoptotic state if the cells are proliferating. The changes of cell life are accompanied by a decrease of nuclear sphingomyelin and increase of bax protein. 相似文献