Comparative Effects of Deferiprone and Salinomycin on Lead-Induced Disturbance in the Homeostasis of Intrarenal Essential Elements in Mice

Lead (Pb) exposure induces severe nephrotoxic effects in humans and animals. Herein, we compare the effects of two chelating agents, salinomycin and deferiprone, on Pb-induced renal alterations in mice and in the homeostasis of essential elements. Adult male mice (Institute of Cancer Research (ICR)) were randomized into four groups: control (Ctrl)—untreated mice administered distilled water for 28 days; Pb-exposed group (Pb)—mice administered orally an average daily dose of 80 mg/kg body weight (BW) lead (II) nitrate (Pb(NO₃)₂) during the first two weeks of the experimental protocol followed by the administration of distilled water for another two weeks; salinomycin-treated (Pb + Sal) group—Pb-exposed mice, administered an average daily dose of 16 mg/kg BW salinomycin for two weeks; deferiprone-treated (Pb + Def) group—Pb-exposed mice, administered an average daily dose of 20 mg/kg BW deferiprone for 14 days. The exposure of mice to Pb induced significant accumulation of the toxic metal in the kidneys and elicited inflammation with leukocyte infiltrations near the glomerulus. Biochemical analysis of the sera revealed that Pb significantly altered the renal function markers. Pb-induced renal toxicity was accompanied by a significant decrease in the endogenous renal concentrations of phosphorous (P), calcium (Ca), copper (Cu) and selenium (Se). In contrast to deferiprone, salinomycin significantly improved renal morphology in Pb-treated mice and decreased the Pb content by 13.62% compared to the Pb-exposed group. There was also a mild decrease in the renal endogenous concentration of magnesium (Mg) and elevation of the renal concentration of iron (Fe) in the salinomycin-treated group compared to controls. Overall, the results demonstrated that salinomycin is a more effective chelating agent for the treatment of Pb-induced alterations in renal morphology compared to deferiprone.     

Carbon foam derived from pitches modified with mineral acids by a low pressure foaming process

Carbon foams with an anisotropic texture and high mechanical strength were produced using precursors obtained after thermo-oxidation treatment of commercial coal-tar pitch with H₂SO₄ and HNO₃. The investigations of the relation between the properties of the precursor and the structure of obtained foam indicate, that the composition and softening point of the pitch precursor significantly affect the foaming process, foam structure and foam mechanical strength. The composition and properties of the modified pitches allow foam formation at relatively low pressure and fast heating rate during the foaming process without a stabilization treatment. The foaming process of pitch-based carbon foams, pre-treatment of the precursors, and the properties of resultant foams are discussed in this paper.     

Influence of megaplastic deformation on the structure and hardness of Al–Cu–Mg alloy after aging

Methods of electron microscopy and X-ray diffraction have been used to investigate structural and phase transformations in the aluminum alloy of grade A2024 (Al–4.5 Cu–1.37 Mg–0.61 Mn–0.07 Si–0.27 Fe–0.02 Zn–0.02 Ti (wt %)) after aging and deformation by shear under high quasi-static pressure. It has been shown that the combination of two-stage aging with megaplastic deformation leads to the refinement of the structure to a nanolevel and to strengthening of the alloy (to an increase in the microhardness to 3000 MPa). The values of true deformation at which the deformation-induced dissolution of the particles of the strengthening S phase occurs have been determined.     

Low-temperature synthesis of the multiferroic compound BiFeO<Subscript>3</Subscript>

A novel, low-temperature process is proposed for the synthesis of the multiferroic compound BiFeO₃. It enables the preparation of nanoparticulate material at temperatures as low as 200–250°C. An important role in the low-temperature synthesis of bismuth orthoferrite is played by ammonium nitrate additions and excess bismuth oxide.     

Possible Application of γ-Ray Spectrometers Based on CdZnTe Detectors

New semiconductor -ray detectors based on CdZnTe have been developed in the last few years, and they are now being widely used. Their advantages are small size and possibility of operating without cooling. In the present work, these detectors are used to measure the radiation from spent fuel assemblies in holding ponds and dry storage sites, unirradiated nuclear materials, and radioactive wastes. The results are analyzed and compared with other types of detectors. The possible applications of CdZnTe-type detectors are determined.     

Prediction of hardening of binary iron alloys due to nitriding on the basis of calculation models

Conclusions  

Examination of the failure kinetics of polymethyl methacrylate-paraffin adhesion joint

Translated from Fiziko-Khimicheskaya Mekhanika Materialov, No. 1, pp. 80–83, January–February, 1989.