A 3D-CAM system for quick prototyping and microfabrication using excimer laser micromachining

A 3D CAM tool for rapid prototyping and small-scale production of MEMS devices based on excimer laser ablation process has been developed. The system’s algorithms use the 3D geometry of a microstructure, defined in a CAD model, and parameters that influence the process (etch rate, wall angle, stitching errors, etc.) to automatically generate a precise NC part program for the excimer laser machine.The performance of the system has been verified by NC part program generation for several 3D microstructures and subsequent machining trials. Stitching errors of 23.4±2.2 μm wide and 3.4±1.5 μm height were observed when overlap size between adjacent volumes were zero, when ablating 100×100 μm features in PC at fluence of 0.9 J/cm² using a workpiece dragging technique.When the size of the overlap was optimised by software based on optimal process parameters determined by Taguchi design of experiment method (DOE) and incorporated in the mask design the maximum stitching errors are reduced to 13.4±2.2 μm wide and 1.4±0.9 μm in height under the same conditions. Employing the hexagonal shaped mask with incorporated size of the image overlap, horizontal-stitching errors with width of 2.4±0.2 μm wide and 1.4±0.2 μm high were observed.The software simplifies part program creation and is useful for excimer laser operators who currently use a tedious trial and error process to generate microstructure parts.     

The effects of heating rate on the dose response characteristics of TLD-200, TLD-300 and TLD-400

In the given study; the effects of heating rates on the dose response characteristics of CaF₂:Dy (TLD-200), CaF₂:Tm (TLD-300) and CaF₂:Mn (TLD-400) crystals have been investigated using the dose dependence curve and dose response function f(D). It was observed from the dose response functions that the linearity and behaviour of the TL glow peaks of TLD-200 and TLD-400 are affected, but the TLD-300 is not affected from the heating rate.     

Human serum albumin (HSA) adsorption with chitosan microspheres

In this study, chitosan microspheres were prepared and characterized for adsorption of human serum albumin (HSA) as affinity sorbent. The chitosan microspheres were obtained with a “suspension crosslinking technique” in the size range of 30–700 μm by using a crosslinker, i.e., glutaraldehyde. The chitosan microspheres used in HSA adsorption studies were having the average size of 170 ± 81 μm. Adsorption medium pH and the initial HSA concentration in the adsorption medium were changed as 4.0–7.0 and 0.5–2.0 mg HSA/mL, respectively, to investigate the HSA adsorption capacity of chitosan microspheres. Maximum HSA adsorption (i.e., 11.35 mg HSA/g chitosan microspheres) was obtained at pH 5.0 and 1.5 mg HSA/mL of the initial HSA concentration in the adsorption medium was obtained as the saturation value for HSA adsorption. A very common dye ligand, i.e., Cibacron Blue F3GA was attached to the chitosan microspheres to increase the HSA adsorption capacity. Actually, the HSA adsorption capacity was increased up to 15.35 mg HSA/g chitosan microspheres in the case of Cibacron Blue F3GA attached to chitosan microspheres used. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 86: 3035–3039, 2002     

Implicitly Heterogeneous Multi-Stage Programming

Previous work on semantics-based multi-stage programming (MSP) language design focused on homogeneous designs, where the generating and the generated languages are the same. Homogeneous designs simply add a hygienic quasi-quotation and evaluation mechanism to a base language. An apparent disadvantage of this approach is that the programmer is bound to both the expressivity and performance characteristics of the base language. This paper proposes a practical means to avoid this by providing specialized translations from subsets of the base language to different target languages. This approach preserves the homogeneous “look” of multi-stage programs, and, more importantly, the static guarantees about the generated code. In addition, compared to an explicitly heterogeneous approach, it promotes reuse of generator source code and systematic exploration of the performance characteristics of the target languages. To illustrate the proposed approach, we design and implement a translation to a subset of C suitable for numerical computation, and show that it preserves static typing. The translation is implemented, and evaluated with several benchmarks. The implementation is available in the online distribution of MetaOCaml.     

The relationship of typographic arrangement to the learning of technical training material.

"… two newly developed methods of typographic arrangement, square span and spaced unit, may possess certain advantages over the usual arrangement. While square span slowed the reader on first encounter, this effect tended to diminish with practice; spaced unit had little effect upon reading speed. The reader found the newer arrangements less acceptable than the more traditional, but this feeling was less marked when the "thought units" in the arrangement were small rather than large. The chief effect upon immediate retention produced by the newer arrangements compared to the older was to provide an increase in test scores for the more able readers. It should be emphasized that the advantages of the newer arrangement are best described as potential, since they interfere with strongly developed reading habits." (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Magnetic chitosan microspheres: preparation and characterization

In this study, magnetic chitosan microspheres were prepared in a well shaped spherical form with a size range of 100 to 250 μm (size distribution ±15 to ±40 μm, respectively) by the suspension cross-linking technique for use in the application of magnetic carrier technology. The magnetic material (i.e. Fe₃O₄) used in the preparation of the magnetic chitosan microspheres was prepared by precipitation from FeSO₄ and Fe₂(SO₄)₃ solutions in basic medium and then ground to the desired size (i.e. 1–5 μm). The morphological and magnetic properties of the microspheres were characterized by different techniques (i.e. SEM, optical microscopy, magnetometry). The results demonstrated that the stirring rate of the suspension medium and the Fe₃O₄/chitosan ratio are the most effective parameters for the size/size distribution and the magnetic quality of the microspheres, while the chitosan molecular weight (MW) has no significant effect on these properties for the given MW range (i.e. 150 to 650 kDa). The best magnetic quality of the magnetic chitosan microspheres is around 9.1 emu/g microsphere at 10 kG magnetic field intensity.     

Different control applications on a vehicle using fuzzy logic control

In this paper, the active suspension control of a vehicle model that has five degrees of freedom with a passenger seat using a fuzzy logic controller is studied. Three cases are taken into account as different control applications. In the first case, the vehicle model having passive suspensions with an active passenger seat is controlled. In the second case, active suspensions with passive passenger seat combination are controlled. In the third case, both the passenger seat and suspensions have active controllers. Vibrations of the passenger seat in the three cases due to road bump input are simulated. At the end of the study, the results are compared in order to select the combination that supplies the best ride comfort.     

4-Aminophenyl boronic acid modified gold platforms for influenza diagnosis

As a potential pandemic threat to human health, there has been an urgent need for rapid, sensitive, simpler and less expensive detection method for the highly pathogenic influenza A virus. For this purpose, Quartz Crystal Microbalance (QCM) and Surface Plasmon Resonance (SPR) sensors have been developed for the recognition of hemagglutinin (HA) which is a major protein of influenza A virus. 4-Aminophenyl boronic acid (4-APBA) has been synthesized and used as a new ligand for binding of sialic acid (SA) via boronic acid–sugar interaction. SA has an important role in binding of HA. QCM and SPR sensor surfaces have been modified with thiol groups and then 4-APBA and SA have been immobilized on sensor surfaces, respectively. Sensor surfaces have been screened with AFM and used for the determination of HA from aqueous solution. The selective recognition of the QCM and SPR sensors toward Concanavalin A has been reported in this work. Also, the binding capacity and detection limits of QCM and SPR sensors have been calculated and detection limits were found to be 4.7 × 10^? 2 μM, (0.26 μg ml^? 1) and 1.28 × 10^? 1 μM, (0.72 μg ml^? 1) in the 95% confidence interval, respectively.     

Gold‐Coated Fe3O4 Nanoroses with Five Unique Functions for Cancer Cell Targeting,Imaging, and Therapy

The development of nanomaterials that combine diagnostic and therapeutic functions within a single nanoplatform is extremely important for molecular medicine. Molecular imaging with simultaneous diagnosis and therapy will provide the multimodality needed for accurate diagnosis and targeted therapy. Here, gold‐coated iron oxide (Fe₃O₄@Au) nanoroses with five distinct functions are demonstrated, integrating aptamer‐based targeting, magnetic resonance imaging (MRI), optical imaging, photothermal therapy. and chemotherapy into one single probe. The inner Fe₃O₄ core functions as an MRI agent, while the photothermal effect is achieved through near‐infrared absorption by the gold shell, causing a rapid rise in temperature and also resulting in a facilitated release of the anticancer drug doxorubicin carried by the nanoroses. Where the doxorubicin is released, it is monitored by its fluorescence. Aptamers immobilized on the surfaces of the nanoroses enable efficient and selective drug delivery, imaging, and photothermal effect with high specificity. The five‐function‐embedded nanoroses show great advantages in multimodality.