Investigation of time-dependent characteristics of materials and micromechanisms of plastic deformation on a submicron scale by a new pulse indentation technique

A new pulse technique is proposed to investigate dynamics and micromechanisms of plastic deformations of materials underneath the indenter during microindentation. It is established that the process of indenter penetration under pulse loading conditions can be described by several distinct stages (as many as four in some cases) differing in kinetics and activation parameters. In each investigated material, the first stage was characterized by a high strain rate (10³ s^–1) and the high contact stresses (dynamic hardness), which exceeded static hardness by factor of 5–10. Typical values of activation volumes during the first stage were of the order of 10^–30 m³, i.e. close to the volume occupied by an atom (ion) in a lattice. During the second and the subsequent stages, the activation volume in ionic crystals increased up to about 10^–28 m³,( i.e. 10b ³, where b is Burger's vector of glide dislocations). Dynamics of initial stages of the indenter penetration was, therefore, determined by elastic and subsequently by plastic deformation, which is carried out by non-equilibrium point defects (most likely by interstitials or crowdions). A relative role of point defects in the process of mass transfer underneath the indenter and its contribution to microhardness is estimated. In soft materials (NaCl, LiF, Pb) during long indentation times (1 s) contribution of point defects can be estimated as more than 10%, and in the case of hard materials (Si, amorphous alloys) became closer to 100%. Dynamics of the final stages of the indenter penetration in soft crystals were governed by the dislocation creep. In all investigated materials for short indentation times (1 s) plastic deformation underneath the indenter occurred predominantly via generation and motion of interstitials and their clusters containing a few atoms.     

Population computation of vectorial transformations

Many neurons of the central nervous system are broadly tuned to some sensory or motor variables. This property allows one to assign to each neuron a preferred attribute (PA). The width of tuning curves and the distribution of PAs in a population of neurons tuned to a given variable define the collective behavior of the population. In this article, we study the relationship of the nature of the tuning curves, the distribution of PAs, and computational properties of linear neuronal populations. We show that noise-resistant distributed linear algebraic processing and learning can be implemented by a population of cosine tuned neurons assuming a nonuniform but regular distribution of PAs. We extend these results analytically to the noncosine tuning and uniform distribution case and show with a numerical simulation that the results remain valid for a nonuniform regular distribution of PAs for broad noncosine tuning curves. These observations provide a theoretical basis for modeling general nonlinear sensorimotor transformations as sets of local linearized representations.     

A Unifying and Rigorous Shape from Shading Method Adapted to Realistic Data and Applications

We propose a new method for the Lambertian Shape From Shading (SFS) problem based on the notion of Crandall-Lions viscosity solution. This method has the advantage of requiring the knowledge of the solution (the surface to be reconstructed) only on some part of the boundary and/or of the singular set (the set of the points at maximal intensity). Moreover it unifies in an unique mathematical formulation the works of Rouy et al. [34, 50], Falcone et al. [21], Prados et al. [46, 48, 49], based on the notion of viscosity solutions and the work of Dupuis and Oliensis [17] dealing with classical solutions and value functions. Also, it allows to generalize their results to the “perspective SFS” problem recently simultaneously introduced in [13,46,55]. While the theoretical part has been developed in [44], in this paper we give some stability results and we describe numerical schemes for the SFS based on this method. We construct provably convergent and robust algorithms. Finally, we apply our SFS method to real images and we suggest some real-life applications.     

Large-Eddy Simulation of the Lid-Driven Cubic Cavity Flow by the Spectral Element Method

This paper presents the large-eddy simulation of the lid-driven cubic cavity flow by the spectral element method (SEM) using the dynamic model. Two spectral filtering techniques suitable for these simulations have been implemented. Numerical results for Reynolds number Re=12,000 are showing very good agreement with other experimental and DNS results found in the literature.     

Uniform controllability of semidiscrete approximations of parabolic control systems

Controlling an approximation model of a controllable infinite dimensional linear control system does not necessarily yield a good approximation of the control needed for the continuous model. In the present paper, under the main assumptions that the discretized semigroup is uniformly analytic, and that the control operator is mildly unbounded, we prove that the semidiscrete approximation models are uniformly controllable. Moreover, we provide a computationally efficient way to compute the approximation controls. An example of application is implemented for the one- and two-dimensional heat equation with Neumann boundary control.     

Heat inactivation of hepatitis A virus in dairy foods

Experiments were performed to determine the thermal resistance of hepatitis A virus (HAV) in three types of dairy products containing increased amounts of fat content (skim milk, homogenized milk; 3.5% MFG, and table cream; 18% MFG). HAV-inoculated dairy products were introduced into custom-made U-shaped microcapillary tubes that in turn were simultaneously immersed in a waterbath, using custom-made floating boats and a carrying platform. Following exposure to the desired time and temperature combinations, the contents of each of the tubes was retrieved and was tested by plaque assay to determine the reduction in virus titer. Our data indicated that < 0.5 min at 85 degrees C was sufficient to cause a 5-log reduction in HAV titer in all three dairy products, whereas at 80 degrees C, < or = 0.68 min (for skim and homogenized milk), and 1.24 min (for cream) were needed to cause a similar log reduction. Using a nonlinear two-phase negative exponential model (two-compartment model) to analyze the data, it was found that at temperatures of 65, 67, 69, 71, and 75 degrees C, significantly (P < 0.05) higher exposure times were needed to achieve a 1-log reduction in virus titer in cream, as compared to skim and homogenized milk. For example, at 71 degrees C, a significantly (P < 0.05) higher exposure time of 0.52 min (for cream) was needed as compared to < or = 0.18 min (for skim and homogenized milk) to achieve a 1-log reduction in virus titer. A similar trend of inactivation was observed at 73 and 75 degrees C where significantly (P < 0.05) higher exposure times of 0.29 to 0.36 min for cream were needed to cause a 1-log reduction in HAV in cream, as compared to < or = 0.17 min for skim and homogenized milk. This study has provided information on the heat resistance of HAV in skim milk, homogenized milk, and table cream and demonstrated that an increase in fat content appears to play a protective role and contributes to the heat stability of HAV.     

The Addiction-Stroop test: Theoretical considerations and procedural recommendations.

Decisions about using addictive substances are influenced by distractions by addiction-related stimuli, of which the user might be unaware. The addiction-Stroop task is a paradigm used to assess this distraction. The empirical evidence for the addiction-Stroop effect is critically reviewed, and meta-analyses of alcohol-related and smoking-related studies are presented. Studies finding the strongest effects were those in which participants had strong current concerns about an addictive substance or such concerns were highlighted through experimental manipulations, especially those depriving participants of the substance. Theories to account for addiction-related attentional bias are discussed, of which the motivational theory of current concerns appears to provide the most complete account of the phenomenon. Recommendations are made for maximizing the precision of the addiction-Stroop test in future research. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Human Mig chemokine: biochemical and functional characterization

Mig is a chemokine of the CXC subfamily that was discovered by differential screening of a cDNA library prepared from lymphokine-activated macrophages. The mig gene is inducible in macrophages and in other cells in response to interferon (IFN)-gamma. We have transfected Chinese hamster ovary (CHO) cells with cDNA encoding human Mig and we have derived CHO cell lines from which we have purified recombinant human Mig (rHuMig). rHuMig induced the transient elevation of [Ca2+]i in human tumor-infiltrating T lymphocytes (TIL) and in cultured, activated human peripheral blood-derived lymphocytes. No responses were seen in human neutrophils, monocytes, or Epstein-Barr virus-transformed B lymphoblastoid cell lines. rHuMig was chemotactic for TIL by a modified Boyden chamber assay but rHuMig was not chemotactic for neutrophils or monocytes. The CHO cell lines, IFN-gamma-treated human peripheral-blood monocytes, and IFN-gamma-treated cells of the human monocytic cell line THP-1 all secreted multiple and identical HuMig species as revealed by SDS-PAGE. Using the CHO-derived rHuMig, we have shown that the species' heterogeneity is due to proteolytic cleavage at basic carboxy-terminal residues, and that the proteolysis occurs before and not after rHuMig secretion by the CHO cells. The major species of secreted rHuMig ranged from 78 to 103 amino acids in length, the latter corresponding to the full-length secreted protein predicted from the HuMig cDNA. Carboxy-terminal-truncated forms of rHuMig were of lower specific activity compared to full-length rHuMig in the calcium flux assay, and the truncated species did not block the activity of the full-length species. It is likely that HuMig plays a role in T cell trafficking and perhaps in other aspects of the physiology of activated T cells.