Chitosan amphiphiles provide new drug delivery opportunities

Chitosan, an acid soluble and renewable biopolymer, was first studied as a drug delivery agent in 1990. This review focuses on the relatively newer self‐assembling chitosan amphiphiles and their use as drug delivery agents. Chitosan amphiphiles, first introduced in the late 1990s, are prepared by conjugating hydrophobic and sometimes additional hydrophilic units to chitosan. These amphiphiles self‐assemble in aqueous media at neutral pH to form micelles, with critical micellar concentrations (CMCs) ranging from 0.09 to 700 µg mL^?1. The CMCs depend on the actual molecular architecture, molecular weight and hydrophobic character, but are typically lower than the values reported for block copolymer amphiphiles. As well as linear amphiphiles in which chitosan is derivatised with hydrophobic pendant groups, new claw amphiphiles have been prepared in which chitosan amphiphiles radiate geometrically from a dendrimer core. These chitosan amphiphiles (linear and claw) have been exploited as drug delivery agents and they increase the oral bioavailability of hydrophobic drugs up to sixfold, deliver hydrophobic drugs to tumours, genes to the liver via the intravenous route, genes to the muscle via the intramuscular routes and small interfering RNAs to tumours via the intratumoural route. Chitosan amphiphile nanoparticles also deliver peptides to the brain via the intravenous and oral routes. © 2014 Society of Chemical Industry     

Toward an interactive poster using digital watermarking and a mobile phone camera

A method for embedding a watermark in print media, posters or other paper printouts and reading the watermark information blindly with a camera phone is proposed. A subtractive-additive embedding method is applied in which the message is coded with a directed periodic pattern. The message is detected and read by searching regularities in the autocorrelation function of a periodic signal. The robustness to disturbance occurring during printing process due to air interface and camera phone properties is ensured using noise reduction, modified JND model, enhanced peak detection with filtering and shaping and two-level coding of the message. The validity of the approach is proven with tests, and an application example of an interactive poster is examined.     

Supporting the design of data integration requirements during the development of data warehouses: a communication theory-based approach

Data warehouses (DW) form the backbone of data integration that is necessary for analytical applications, and play important roles in the information technology landscape of many industries. We introduce an approach for addressing the fundamental problem of semantic heterogeneity in the design of data integration requirements during DW development. In contrast to ontology-driven or schema-matching approaches, which propose the automatic resolution of differences ex-post, our approach addresses the core problem of data integration requirements: understanding and resolving different contextual meanings of data fields. We ground the approach firmly in communication theory and build on practices from agile software development. Besides providing relevant insights for the design of data integration requirements, our findings point to communication theory as a sound underlying foundation for a design theory of information systems development.     

Solving parity games by a reduction to SAT

This paper presents a reduction from the problem of solving parity games to the satisfiability problem in propositional logic (SAT). The reduction is done in two stages, first into difference logic, i.e. SAT combined with the theory of integer differences, an instance of the SAT modulo theories (SMT) framework. In the second stage the integer variables and constraints of the difference logic encoding are replaced with a set of Boolean variables and constraints on them, giving rise to a pure SAT encoding of the problem. The reduction uses Jurdziński?s characterisation of winning strategies via progress measures. The reduction is motivated by the success of SAT solvers in symbolic verification, bounded model checking in particular. The paper reports on prototype implementations of the reductions and presents some experimental results.     

Anthocyanins and betalains as light-harvesting pigments for dye-sensitized solar cells

We present the photoelectrochemical properties of dye-sensitized solar cells using natural pigments containing betalains and anthocyanins as sensitizers. The dyes extracted from grape, mulberry, blackberry, red Sicilian orange, Sicilian prickly pear, eggplant and radicchio have shown a monochromatic incident photon to current efficiency (IPCE) ranging from 40% to 69%. Short circuit photocurrent densities (J_sc) up to 8.8 mA/cm², and open circuit voltage (V_oc) ranging from 316 to 419 mV, were obtained from these natural dyes under 100 mW/cm² (AM 1.5) simulated sunlight. The best solar conversion efficiency of 2.06% was achieved with Sicilian prickly pear fruits extract. The influence of pH and co-absorbers on natural sensitizers, were investigated and discussed.     

Locative and Directional Prepositions in Conceptual Spaces: The Role of Polar Convexity

We approach the semantics of prepositions from the perspective of conceptual spaces. Focusing on purely spatial locative and directional prepositions, we analyze both types of prepositions in terms of polar coordinates instead of Cartesian coordinates. This makes it possible to demonstrate that the property of convexity holds quite generally in the domain of prepositions of location and direction, supporting the important role that this property plays in conceptual spaces.     

Reaction of dithiocarbamates with malononitrile dimer; simple synthesis of new 1,4-dihydropyridine-2-thiols

Dithiacarbamates reacted with malononitrile dimer to give 1,4-dihydropyridine-2-thiols. The structures of the obtained products were proven by IR, mass, and NMR spectra and elemental analyses. The reaction mechanism is also discussed.     

Planar-Based Visual Inertial Navigation: Observability Analysis and Motion Estimation

In this paper, we address the problem of ego-motion estimation by fusing visual and inertial information. The hardware consists of an inertial measurement unit (IMU) and a monocular camera. The camera provides visual observations in the form of features on a horizontal plane. Exploiting the geometric constraint of features on the plane into visual and inertial data, we propose a novel closed form measurement model for this system. Our first contribution in this paper is an observability analysis of the proposed planar-based visual inertial navigation system (VINS). In particular, we prove that the system has only three unobservable states corresponding to global translations parallel to the plane, and rotation around the gravity vector. Hence, compared to general VINS, an advantage of using features on the horizontal plane is that the vertical translation along the normal of the plane becomes observable. As the second contribution, we present a state-space formulation for the pose estimation in the analyzed system and solve it via a modified unscented Kalman filter (UKF). Finally, the findings of the theoretical analysis and 6-DoF motion estimation are validated by simulations as well as using experimental data.