Clustering of high throughput gene expression data

High throughput biological data need to be processed, analyzed, and interpreted to address problems in life sciences. Bioinformatics, computational biology, and systems biology deal with biological problems using computational methods. Clustering is one of the methods used to gain insight into biological processes, particularly at the genomics level. Clearly, clustering can be used in many areas of biological data analysis. However, this paper presents a review of the current clustering algorithms designed especially for analyzing gene expression data. It is also intended to introduce one of the main problems in bioinformatics – clustering gene expression data – to the operations research community.     

Honeymoon with IWBs: A qualitative insight in primary students' views on instruction with interactive whiteboard

The main purpose of this study was to investigate the views of primary students about interactive whiteboard [IWB] use in their classes from attitudinal and pedagogical perspectives. Research was designed as an empirical approach to phenomenology. Data was collected from fifty primary students (fourth to eighth) through focus group interviews. Nvivo 9 qualitative data analysis software was used to analyze data. Results showed that students like instruction with IWB especially for such reasons/capabilities as practical and economical use, better visual presentation, and test-based use. Students were predominantly uncomfortable with the technical problems. They believed that instruction with IWB positively impacted their learning especially because of visualization and contextualization, effective presentation, test-based use, and motivational factors. Finally it was inferred that IWBs were not used to their full potential, and both technical problems and common practices indicated that teachers were still at an initial stage of transmission to instruction with IWB and they needed both technical and pedagogical training.     

Multirobot coordination in pick-and-place tasks on a moving conveyor

This paper considers the problem of multirobot coordination in pick-and-place tasks on a conveyor band. The robot team is composed of identical robots with mutually exclusive, but neighboring workspaces. The products are fed in at one end of the band, move through each workspace sequentially until being picked up and are collected at the other end—if not picked up interim. Each robot has the same task—that is picking up and packaging as many products as possible. We propose an approach based on noncooperative game theory where each robot uses local observations of the conveyor band and their neighbors' actions in order to decide on its actions. The developed algorithm has been implemented and tested in a simulated manufacturing environment using Webots. Results obtained from the simulations are analyzed using a variety of statistical performance measures.     

Design of a framework for modeling, integration and simulation of physiological models

Multiscale modeling and integration of physiological models carry challenges due to the complex nature of physiological processes. High coupling within and among scales present a significant challenge in constructing and integrating multiscale physiological models. In order to deal with such challenges in a systematic way, there is a significant need for an information technology framework together with related analytical and computational tools that will facilitate integration of models and simulations of complex biological systems. Physiological Model Simulation, Integration and Modeling Framework (Phy-SIM) is an information technology framework providing the tools to facilitate development, integration and simulation of integrated models of human physiology. Phy-SIM brings software level solutions to the challenges raised by the complex nature of physiological systems. The aim of Phy-SIM, and this paper is to lay some foundation with the new approaches such as information flow and modular representation of the physiological models. The ultimate goal is to enhance the development of both the models and the integration approaches of multiscale physiological processes and thus this paper focuses on the design approaches that would achieve such a goal.     

Iterative performance improvement of fuzzy control systems for three tank systems

This paper suggests the performance improvement of fuzzy control systems (FCSs) for three tank systems using iterative feedback tuning (IFT). The stable design of Takagi–Sugeno–Kang fuzzy controllers is guaranteed by means of a stability theorem based on LaSalle’s global invariant set theorem formulated for a class of multi input-multi output (MIMO) nonlinear processes. An IFT algorithm characterized by setting the step size to guarantee the FCS stability is proposed. The theoretical approaches are applied in a case study that deals with the IFT-based stable design of fuzzy controllers dedicated to the level control of a cylindrical three tank system as a representative MIMO system. A set of experimental results for a laboratory setup illustrates the performance improvement.     

Robust estimation and hypothesis testing under short-tailedness and inliers

Estimation and hypothesis testing based on normal samples censored in the middle are developed and shown to be remarkably efficient and robust to symmetric shorttailed distributions and to inliers in a sample. This negates the perception that sample mean and variance are the best robust estimators in such situations (Tiku, 1980; Dunnett, 1982). Professor Emeritus, Department of Mathematics and Statistics, McMaster University, Professor Emeritus, Department of Mathematics and Statistics, McMaster University,     

Comparison of OR and AI methods in discrete manufacturing using fuzzy logic

Since 1950s the techniques of Operations Research (OR) and Optimization have been utilized to increase the efficiency of the production systems. With the widespread use of computers, it has even become easier to deal with industrial problems. However the complexity of the problems still reveals the difficulty in providing solutions. The use of artificial intelligence (AI) seems to attract the attention of the researcher to overcome to the difficulties. This has already been realized with several successful applications. In this study, the use of AI and OR techniques is compared using fuzzy logic. The progress of manufacturing systems, characteristics of production processes, system managements and system behavior are taken into account. The study is focussed on only discrete manufacturing.