A New Approach to Calculate the Mud Density for Wellbore Stability Using the Asymptotic Homogenization Theory

Abstract

This study addresses mud density prediction as part of wellbore stability analyses considering effective rock properties and using friction and elastic theories to determine the deviator stress at failure. The effective rock properties for different sandstone porosities were obtained through the theory of asymptotic homogenization, and the wall vicinity stresses at the borehole wall were estimated considering friction and elastic theories. The use of the method of asymptotic homogenization (MHA) allows obtaining effective rock mechanical properties varying in porosity and saturation conditions.     

Convergent optical correlator aligment based on frequency filtering

The convergent correlator is widely used but it presents the drawback of the alignment requirements: fine focusing of the input scene Fourier transform on the filter plane, filter centering, scaling the scene Fourier transform to match the filter size, and azimuth matching of the filter with the input scene. We propose a set of tests to obtain a precise alignment of the convergent correlator. These methods are based on frequency filtering properties and they are applicable either for amplitude input or for phase-encoded input. The tests we present allow us to fulfill all the alignment requirements. The theory on which these tests are based is explained. The experimental results obtained during the alignment procedure are presented. We show some additional verifications of the correct alignment of the convergent correlator.     

Requirements Reuse for Improving Information Systems Security: A Practitioner’s Approach

Information systems security issues have usually been considered only after the system has been developed completely, and rarely during its design, coding, testing or deployment. However, the advisability of considering security from the very beginning of the system development has recently begun to be appreciated, and in particular in the system requirements specification phase. We present a practical method to elicit and specify the system and software requirements, including a repository containing reusable requirements, a spiral process model, and a set of requirements documents templates. In this paper, this method is focused on the security of information systems and, thus, the reusable requirements repository contains all the requirements taken from MAGERIT, the Spanish public administration risk analysis and management method, which conforms to ISO 15408, Common Criteria Framework. Any information system including these security requirements must therefore pass a risk analysis and management study performed with MAGERIT. The requirements specification templates are hierarchically structured and are based on IEEE standards. Finally, we show a case study in a system of our regional administration aimed at managing state subsidies.     

An audit of magnetic resonance imaging in the paediatric orthopaedic setting

AIMS: To determine when magnetic resonance imaging (MRI) is helpful in the management of a selected group of paediatric orthopaedic patients. METHODS: A retrospective analysis of 131 MRI scans was undertaken with allocation into seven categories based on clinical presentation. RESULTS: MRIs performed for spinal, congenital and intra-articular pathology, as well as for growth plate assessment correlated well with subsequent clinical and/or surgical findings. Three of ten MRIs (30%) incorrectly assessed whether a foreign body was present with a sensitivity of 0.60 and specificity of 0.80. Three of 20 MRIs (15%) could not accurately distinguish between oedema/effusion and frank infection. Here sensitivity was 1.00 and specificity was 0.73. MRIs performed for assessment of tumours were accurate with respect to margins and extent. Assessment of pathology with MRI was never the indication for MRI, thus it was not surprising that in four of 27 soft tissue tumours (sensitivity of 0.88 and specificity of 0.63) MRI did not correlate with subsequent histological findings. CONCLUSIONS: MRI plays an important role in the assessment of a wide range of musculo-skeletal pathology. MRI does not, and could not be expected to, replace the need for incisional biopsy for tumour diagnosis. It must be used with caution where tissues have been previously explored for foreign bodies. Interpretation of MRI in musculoskeletal infection must consider its timing in the evolution of the patient's infection.     

Separating hierarchical relations and word order in language production: is proximity concord syntactic or linear?

In this paper we address the question whether hierarchical relations and word order can be separated in sentence production. In two experiments, we assess whether subject-verb agreement errors (such as 'The time for fun and games are over') require linear proximity of a so-called 'local' noun ('games' in the example) to the verb. In the first experiment, we found a proximity effect when participants were asked to complete sentential beginnings of the kind: 'The helicopter for the flights'. In the second experiment, we asked participants to produce a question such as 'Is the helicopter for the flights safe?'. The syntactic relation between the subject noun and the local noun is the same in the two experiments, but the linear position of the local noun is different. The distribution of agreement errors was similar in the two experiments. We argue that these data provide evidence for a stage in language production in which a syntactic structure is built prior to a stage in which words are assigned to their linear position. Agreement is computed during the first stage.     

Tonic regulation of excitation-contraction coupling by basal protein kinase C activity in isolated cardiac myocytes

A high-speed imaging technique was used to investigate the effects of inhibitors and activators of protein kinase C (PKC) on the [Ca2+]i transients and contraction of fura-2 loaded rat ventricular cardiac myocytes. The amplitude of the [Ca2+]i transient was reduced following treatment with 100 nM phorbol 12,13-dibutyrate (PDBu), whereas the PKC inhibitors staurosporine (0.5 microM) and calphostin C (10 microM) increased [Ca2+]i transient amplitude, elevated basal [Ca2+]i and slowed the decay of the [Ca2+]i transient. These changes were paralleled by similar alterations in the rate and extent of cell shortening. The activity of nitrendipine-sensitive Ca2+ channels was monitored indirectly as the rate of Mn2+ quench of cytosolic fura-2 in electrically-paced cells. PDBu reduced Mn2+ influx by six-fold, whereas staurosporine and calphostin C increased the influx rate by eight-fold and seven-fold over basal quench, respectively. The caffeine releasable Ca2+ pool was reduced in the presence of PDBu and increased transiently in presence of staurosporine. The effects of PKC activation and inhibition on sarcoplasmic reticulum Ca2+ content may be secondary to alterations of sarcolemmal Ca2+ influx. However, the PKC inhibitors also decreased the rate of sarcoplasmic reticulum Ca2+ uptake in permeabilized myocytes, suggesting that a direct effect of PKC on the sarcoplasmic reticulum may contribute to the prolongation of the [Ca2+]i transient under these conditions. The present work demonstrates that basal PKC activity has a potent depressant effect, mediated primarily through inhibition of sarcolemmal Ca2+ influx, which may play a key role in setting the basal tone of cardiac muscle.     

Prostaglandins suppress an outward potassium current in embryonic rat sensory neurons

One of the challenges in understanding ciliary and flagellar motility is determining the mechanisms that locally regulate dynein-driven microtubule sliding. Our recent studies demonstrated that microtubule sliding, in Chlamydomonas flagella, is regulated by phosphorylation. However, the regulatory proteins remain unknown. Here we identify the 138-kD intermediate chain of inner arm dynein I1 as the critical phosphoprotein required for regulation of motility. This conclusion is founded on the results of three different experimental approaches. First, genetic analysis and functional assays revealed that regulation of microtubule sliding, by phosphorylation, requires inner arm dynein I1. Second, in vitro phosphorylation indicated the 138-kD intermediate chain of I1 is the only phosphorylated subunit. Third, in vitro reconstitution demonstrated that phosphorylation and dephosphorylation of the 138-kD intermediate chain inhibits and restores wild-type microtubule sliding, respectively. We conclude that change in phosphorylation of the 138-kD intermediate chain of I1 regulates dynein-driven microtubule sliding. Moreover, based on these and other data, we predict that regulation of I1 activity is involved in modulation of flagellar waveform.     

Mode-specific strategy for controlling a single-molecule reaction

Inelastic tunnelling electrons are a proper excitation source to induce chemical transformations on a single adsorbate. When their energy is tuned to that of molecular vibrational states, the modification may follow complex internal vibrational pathways. Here, we analyse our recent results on the selective excitation of ammonium stretching or bending modes to control the outcome of a simple bond-cleavage reaction. With the help of model calculations, we provide a detailed molecular-scale picture of the competing internal pathways leading to molecular movement. A mode-selective strategy, based on local excitations of specific reaction coordinates, has an important drawback when applied to adsorbate systems due to the problem of fast energy randomization. The success of such a mode-selective strategy is determined here by the ability of the scanning tunnelling microscope to study reactivity in the limit of very low yield and very low power irradiation, in a regime where vibrational heating of the adsorbate/surface system becomes negligible.     

Variable-coherence tomography for inverse scattering problems

We propose a technique for determining the pair-correlation function of a quasi-homogeneous medium. The method uses the variation of the spatial-coherence properties of the incident beam to generate two separate volumes of coherence where the field is correlated. Using this specially prepared beam, we reconstruct experimentally the correlation function of a scattering potential by recording the scattered intensity in only one direction.     

Propagation of partially coherent beams through particulate media

When propagating through particulate media, optical beams are degraded owing to scattering. We found that the ratio between the width of the distorted beam and the width of the initial beam decreases when the spatial coherence of the incident beam is reduced. These experimental observations are well described within the paraxial approximation of the transport theory.