Evaluation of the anti-rutting potential of polymer-modified binders by means of creep-recovery shear tests

In the experimental study reported in this paper a creep-recovery shear test method was used to evaluate the anti-rutting potential of different polymer-modified bituminous binders. The effects of several factors related to modification were investigated, such as polymer type (SBS, styrene–butadiene–styrene vs. ethylene–vinyl–acetate), composition (styrene content), structure (linear vs. radial SBS) and dosage (3–6 % by weight of the base bitumen). The effect of short-term aging was also considered by comparing binder response before and after treatment with the rolling thin-film oven test. Following previous work on the development of the test protocol, experimental results were analyzed by referring to shear modulus curves G(t) and to permanent compliance (J _P), obtained by dividing residual strain at the end of the unloading phase by the stress applied during creep loading. Results indicated the effectiveness of the proposed method in discriminating between the behavior of the different polymer-modified binders and in capturing the effects caused by the factors considered in the investigation. Reliable rankings of the binders were established and were explained by referring to the specific behavior of employed modifiers.     

Wind energy in the world: Reality and prospects

This report presents an overview of the various aspects of the use of wind energy for the production of electricity with special regard to: available resources; the state-of-the art of the technology; the worldwide wind energy applications; the present situation and foreseeable development of the world wind energy market in the next two decades; the economics of wind-generated electricity. Possible restraints to and benefits from wind plant integration in utility systems are also considered.     

A diagnostic protocol in cherubism

Cherubism is a rare hereditary maxillo-facial pathology with unknown pathogenesis. The purpose of the present study is to describe a correct diagnostic approach to cherubism, especially for the differential diagnosis with other maxillo-mandibular cystic diseases. Therefore, the typical clinical, radiological, genetical and histopathological aspects of this pathology are examined. Moreover, an adequate therapy for the cases examined in this study is suggested.     

Removal and accumulation of Cu, Ni and Zn in horizontal subsurface flow constructed wetlands: Contribution of vegetation and filling medium

This study investigated the accumulation and removal of Cu, Ni and Zn in two horizontal subsurface flow constructed wetlands for domestic wastewater treatment, which differ by shape, presence of macrophytes and water depth. Between March and December 2007, the three metals were measured in the influent and effluents of the two systems. Average percentage removal rates were extremely low for Cu (3% and 9% in the two beds) and higher for Zn and Ni (between 25 and 35%). Under higher Zn influent concentrations, it was found to be between 78-87%, which is in agreement with other literature data.During the peak standing crop season (August), biomasses of the different parts of Phragmites australis (stems, leaves and flowers, roots and rhizomes) were analysed in terms of weight and heavy metal concentration in order to assess heavy metal distribution among the tissues. It was found that the plants contribute to total heavy metal removal to a lesser extent than the filling medium. Aboveground tissues remove 34% of Cu, 1.8% of Ni and 6.2% of Zn % and, once harvested, their disposal does not appear to pose a problem for the environment. If heavy metals are present at high concentrations in the horizontal subsurface flow bed influent, over time, their accumulation in the filling medium could necessitate special care in the bed's management to avoid release into the surrounding environment.     

Simultaneous nitrification and autotrophic denitrification in fluidized bed reactors using pyrite and elemental sulfur as electron donors

In this study, simultaneous nitrification and autotrophic denitrification (SNAD) with either elemental sulfur or pyrite were investigated in fluidized bed reactors in mesophilic conditions. The reactor performance was evaluated at different ammonium (12-40 mg/L of NH₄⁺-N), nitrate (35-45 mg/L of NO₃^--N), and dissolved oxygen (DO) (0.1-1.5 mg/L) concentrations, with a hydraulic retention time of 12 h. The pyrite reactor supported the SNAD process with a maximum nitrogen removal efficiency of 139.5 mg/(L·d) when the DO concentration was in the range of 0.8-1.5 mg/L. This range, however, limited the denitrification efficiency of the reactor, which decreased from 90.0% ± 5.3% in phases II-V to 67.9% ± 7.2% in phases VI and VII. Sulfate precipitated as iron sulfate (FeSO₄/Fe₂(SO₄)₃) and sodium sulfate (Na₂SO₄) minerals during the experiment. The sulfur reactor did not respond well to nitrification with a low and unstable ammonium removal efficiency, while denitrification occurred with a nitrate removal efficiency of 97.8%. In the pyrite system, the nitrifying bacterium Nitrosomonas sp. was present, and its relative abundance increased from 0.1% to 1.1%, while the autotrophic denitrifying genera Terrimonas, Ferruginibacter, and Denitratimonas dominated the community. Thiobacillus, Sulfurovum, and Trichlorobacter were the most abundant genera in the sulfur reactor during the entire experiment.     

Pharmacophore‐Based Design of Novel Oxadiazoles as Selective Sphingosine‐1‐phosphate (S1P) Receptor Agonists with in vivo Efficacy

Sphingosine‐1‐phosphate (S1P) receptor agonists have shown promise as therapeutic agents for multiple sclerosis (MS) due to their regulatory roles within the immune, central nervous system, and cardiovascular system. Here, the design and optimization of novel [1,2,4]oxadiazole derivatives as selective S1P receptor agonists are described. The structure–activity relationship exploration was carried out on the three dominant segments of the series: modification of the polar head group (P), replacement of the oxadiazole linker (L) with different five‐membered heterocycles, and the use of diverse 2,2′‐disubstituted biphenyl moieties as the hydrophobic tail (H). All three segments have a significant impact on potency, S1P receptor subtype selectivity, physicochemical properties, and in vitro absorption, distribution, metabolism, excretion and toxicity (ADMET) profile of the compounds. From these optimization studies, a selective S1P₁ agonist, N‐methyl‐N‐(4‐{5‐[2‐methyl‐2′‐(trifluoromethyl)biphenyl‐4‐yl]‐1,2,4‐oxadiazol‐3‐yl}benzyl)glycine ( 45 ), and a dual S1P_1,5 agonist, N‐methyl‐N‐(3‐{5‐[2′‐methyl‐2‐(trifluoromethyl)biphenyl‐4‐yl]‐1,2,4‐oxadiazol‐3‐yl}benzyl)glycine ( 49 ), emerged as frontrunners. These compounds distribute predominantly in lymph nodes and brain over plasma and induce long lasting decreases in lymphocyte count after oral administration. When evaluated head‐to‐head in an experimental autoimmune encephalomyelitis mouse model, together with the marketed drug fingolimod, a pan‐S1P receptor agonist, S1P_1,5 agonist 49 demonstrated comparable efficacy while S1P₁‐selective agonist 45 was less potent. Compound 49 is not a prodrug, and its improved property profile should translate into a safer treatment of relapsing forms of MS.     

Photocatalytic transformations of aminopyrimidines on TiO2 in aqueous solution

In this paper, the effect of the presence of humidity and molecular oxygen on the low temperature oxidation of carbon monoxide on a Co₃O₄ powder surface was studied. The interaction between the probe molecules and the Co₃O₄ surface was investigated by means of diffuse reflectance infrared Fourier transform (DRIFT) spectroscopy and quadrupolar mass spectrometry (QMS).

Carbon monoxide interacts with the Co₃O₄ surface and is converted to carbon dioxide at rather low temperature (T≥323 K); the formation of carbonate species is also evident. The reactivity of Co₃O₄ is strongly depressed by humidity: as a matter of fact, in steam conditions carbon monoxide oxidation is significant at temperatures higher than 523 K. Moreover, the formation of carbonate species is more evident than in dry conditions. The Co₃O₄ powder surface interacts with oxygen molecules at T≥323 K to originate several activated surface oxygen species. The activation with oxygen does not appear to facilitate significantly the formation of carbon dioxide.     

Bisubstrate inhibitors of farnesyltransferase: a novel class of specific inhibitors of ras transformed cells

We describe the biological properties of a new class of potent farnesyltransferase (FT) inhibitors designed as bisubstrate analog inhibitors. These inhibitors incorporate the structural motifs of both farnesyl pyrophosphate and the CAAX tetrapeptide, the two substrates of the reaction catalyzed by FT. Both the phosphinate inhibitor, BMS-185878, and the phosphonate inhibitor, BMS-184467, exhibited higher in vitro FT selectivity than some of the previously reported CVFM peptidomimentics and benzodiazepine analogs. Xenopus oocyte maturation induced by microinjected oncogenic Ras proteins was blocked by coinjected BMS-184467 and BMS-185878. However, both inhibitors showed poor cell activity presumably because of the doubly charged nature of the compounds. Thus, masking the charge on the carboxylate ion markedly improved the cell permeability of BMS-185878, leading to BMS-186511, the methyl carboxyl ester prodrug. BMS-186511 inhibited FT activity in whole cells as determined by inhibition of p21 Ras protein processing, inhibition of farnesylation of proteins including Ras and the accumulation of unfarnesylated Ras proteins in the cytosolic fraction. While the cellular effects of these bisubstrate analog inhibitors had no significant effect on growth of untransformed NIH3T3 cells, they produced pronounced inhibition of Ras transformed cell growth. Both the anchorage dependent and independent growth of ras transformed cells were severely curtailed by micromolar concentrations of BMS-186511. We also found that both H-ras and K-ras transformed cells are affected by this bisubstrate inhibitor. However, K-ras transformed cells appear to be less sensitive. The inhibition of FT activity in cells and the ensuing inhibition of ras transformed cell growth is further manifested in distinct morphological changes in cells. Cells flattened, became less refractile and grew in contact inhibited monolayer. Moreover, the highly diffused character of the actin cytoskeleton in the ras transformed cells was dramatically reverted to an organized network of stress cables crisscrossing the entire cells upon treatment with BMS-186511. All of these effects of BMS-186511 are limited to ras transformed cells that utilize farnesylated Ras, but are not seen in transformed cells that use geranylgeranyl Ras or myristoyl Ras. Significantly, these FT inhibitors did not produce any signs of gross cytotoxicity in untransformed, ras transformed cells or other oncogene transformed cells.     

Effects of thermal conduction in microchannel gas coolers for carbon dioxide

A numerical code was developed for an accurate fully three-dimensional simulation of crossflow compact heat exchangers using finned flat tubes with internal microchannels; such components are often employed as gas coolers in transcritical refrigerating machines CO₂ operated. The equations describing the system were discretised by means of a finite-volume and finite-element hybrid technique for strictly adhering to the real heat transfer process regarding the finned surfaces. The numerical code uses recent correlations by different authors for predicting the heat transfer coefficients both refrigerant side and air side. The results of simulations are verified against experimental data reported in the open literature.The aim of this work is to investigate the effects of thermal conduction inside metal on the overall performance of the considered gas coolers; high-resolution meshes for the discretisation of separating wall and fins makes it possible to avoid much of the approximations typical of the traditional approaches. In particular the efficiency of finned surfaces, the real distribution of thermal fluxes between the two fin roots and the effects of thermal conduction along the walls of microchannel flat tubes are extensively discussed.The numerical simulations confirm that the traditional approach for describing fins, which assumes them as adiabatic at the middle section in order to decouple the equations accounting for the effect of different temperatures at the fin roots, can be considered acceptable in a wide range of applications. In a similar way, the conduction on fins along the direction of the air velocity and the longitudinal conduction on tubes produce a negligible effect on the performance of the considered class of heat exchangers.     

Double synchronous occluding tumors of the large bowel: a report of three cases

The development of acute large bowel obstruction secondary to colorectal cancer is very common and, while right hemicolectomy with a primary anastomosis is the accepted procedure for right-sided obstructing tumors, the different strategies performed for left-sided tumors, including staged procedures, Hartmann's procedure, and resection with anastomosis, remain a subject of controversy. We present herein the case reports of three patients who developed two synchronous occlusive tumors of the large bowel. Complete exploration of the entire colon is highly recommended to assess the most feasible therapeutic option in such cases, as the second occlusive tumor, often hidden within the bowel segments, can cause failure of limited resection or intestinal decompression.