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91.
TM Wickizer E Wagner A Cheadle D Pearson W Beery J Maeser B Psaty M VonKorff T Koepsell P Diehr EB Perrin 《Canadian Metallurgical Quarterly》1998,76(1):121-147
The Community Health Promotion Grants Program, sponsored by the Henry J. Kaiser Family Foundation, represents a major health initiative that established 11 community health promotion projects. Successful implementation was characterized by several critical factors: (1) intervention activities; (2) community activation; (3) success in obtaining external funding; and (4) institutionalization. Analysis of the program was based on data from several sources: program reports, key informant surveys, and a community coalition survey. Results indicate that school-based programs focusing on adolescent health problems were the most successful in reaching the populations they were targeting. The majority of the programs were able to attract external funding, thereby adding to their initial resource base. The programs were less successful in generating health promotion activities and in achieving meaningful institutionalization in their communities. 相似文献
92.
JM Perrin SL Ettner TJ McLaughlin SL Gortmaker SR Bloom K Kuhlthau 《Canadian Metallurgical Quarterly》1998,88(6):928-931
OBJECTIVES: The purpose of this study was to determine the effects of poverty, program generosity, and health on state variations in enrollment of children and adolescents in the Supplemental Security Income (SSI) program during recent program expansions. METHODS: The relationship of state SSI rates for 1989 and 1992 to child poverty, health, and program generosity were determined by multiple regression. RESULTS: The mean percentage of children enrolled grew from 0.36% (1989) to 0.75% (1992). Poverty rates accounted for 78% of the variance among states in 1989 and 53% in 1992. Other indicators accounted for little variance. CONCLUSIONS: Differences in state poverty levels explained almost all variation in SSI enrollment. 相似文献
93.
G Yang FX Caroli-Bosc C Laffont D Bianchi S Dantin JC Lefebvre A Doglio 《Canadian Metallurgical Quarterly》1998,43(6):1307-1310
The aim of this work was to specify the time course of response to interferon (IFN) of hepatitis G virus (HGV) and hepatitis C virus (HCV) in coinfected individuals. A group of 33 patients, undergoing 12 months of IFN therapy for chronic hepatitis C, was screened for the presence of both HGV and HCV RNAs to select seven coinfected patients. Spontaneous recovery from HGV infection was excluded through the detection of antibodies to the envelope-2 protein of HGV and HCV isolates were genotyped. Within three months of treatment, we found that HGV RNA was transiently cleared in 6/7 patients, but the rate of long-term favorable response was very low (1/7). In addition, considering the same individuals separately, it was shown that HGV and HCV responded to IFN with different kinetics in 5/7 patients. Taken together, these results underscore the importance of the virological basis of the resistance to IFN treatment. 相似文献
94.
FX Mahon C Fabères S Pueyo P Cony-Makhoul R Salmi JM Boiron G Marit C Bilhou-Nabera A Carrère M Montastruc A Pigneux P Bernard J Reiffers 《Canadian Metallurgical Quarterly》1998,92(11):4059-4065
In a single institution, we have used recombinant interferon- (IFN-) to treat 116 newly diagnosed Philadelphia-positive (Ph+) chronic myeloid leukemia (CML) patients and analyzed the predictive factors for response and survival. The patients whose median age was 50.3 years (range, 9 to 70) were administered IFN- (5 million units/m2/d) subcutaneously. The IFN- dose was subsequently adjusted to maintain the white blood cell and platelet counts between 1.5 and 5 x 10(9)/L, 50 and 100 x 10(9)/L, respectively. At diagnosis, the Sokal score was used to classify the patients into three groups: low (n = 57), intermediate (n = 42), and high risk (n = 16). A complete hematological response (CHR) was achieved in 93 cases (80.2%). Of the 116 patients, 113 were available for cytogenetic evaluation. Fifty patients (43%) achieved a major cytogenetic response (MCR) (=65% marrow Ph- cells), 37 of them having a complete cytogenetic response (CCR). The estimated 5-year survival of the 116 patients was 68% +/- 11% (95% confidence interval [CI]) with a median follow-up of 42 months (range, 3 to 114) and 85% +/- 11% (95% CI) with a median follow-up of 30.9 (range, 3 to 111) when patients were censored at the time of transplantation. Event-free survival at 5 years (adding death and transplant as event) was 46% +/- 11% (95% CI). Using proportional hazards regression to study time-dependent variables, we confirmed that the most significant factor associated with survival was the cytogenetic response (MCR or CCR) (P <.0001). This factor was independent compared with the Sokal score and baseline variables used to calculate the Sokal score. Moreover, using either univariate or multivariate analysis, the achievement of CHR within 3 months was strongly correlated with MCR (P <.0001). Minimum cytogenetic response (mCR, ie, at least 5% of Ph- metaphases) at 3 months was also a significant predictive factor for MCR (P <.0001). These results show that IFN- can induce a high rate of hematological and cytogenetic response when administered in doses leading to myelosuppression. Factors such as the achievement of CHR and mCR within 3 months could be useful to identify early those patients who will not respond to IFN- and who need alternative treatments such as stem cell transplantation. 相似文献
95.
SS Terzyan R Peracaula R de Llorens Y Tsushima H Yamada M Seno FX Gomis-Rüth M Coll 《Canadian Metallurgical Quarterly》1999,285(1):205-214
The RNase 4 family is unique among RNase enzymes, displaying the highest level of sequence similarity and encompassing the shortest polypeptide chain. It is the only one showing high specificity. The human representative is an intracellular and plasma enzyme, first isolated from colon adenocarcinoma cell line HT-29. The crystal structures of human recombinant RNase 4, unliganded and in complex with d(Up), have been determined, revealing in the unique active site an explanation for the uridine specificity. Arg101, at a position not involved in catalysis in the other RNase enzymes, penetrates the enzyme moiety shaping the recognition pocket, a flip that is mediated by the interaction with the (shorter chain) C-terminal carboxylate group, providing an anchoring point for the O4 atom of the substrate uridine. The bulky Phe42 side-chain forces Asp80 to be in the chi1=-72.49 degrees rotamer, accepting a hydrogen bond from Thr44, further converting the latter into a hydrogen bond acceptor. This favours an interaction with the -NH-donor group of uridine at position 3 over that with the =N-acceptor of cytidine. The two chemical groups that distinguish uracyl from cytosine are used by the enzyme to discriminate between these two bases. 相似文献
96.
FH Klebl M Merger FX Hierlmeier R Büttner KD Palitzsch 《Canadian Metallurgical Quarterly》1999,124(3):39-44
HISTORY AND ADMISSION FINDINGS: A 63-year-old man had for 10 months suffered from marked weight loss, night sweats, diffuse abdominal pain and increased stool frequency. He was admitted to evaluate an ultrasonically abnormal focus in the liver parenchyma and elevated liver function parameters. His sclerae were obviously icteric and he looked under-weight. INVESTIGATIONS: He had a hypochromic microcytic anemia and abnormal liver and pancreatic function tests: total bilirubin 3.11 mg/dl, direct bilirubin 2.21 mg/dl, GOT21U/l, gamma-GT 422 U/l, alkaline phosphatase 1449 U/l, alpha-amylase 481 U/l, lipase 2827 U/l. The serum creatinine level was elevated to 1.47 mg/dl. Computed tomography revealed enlarged liver and spleen as well as an enlargement of intraabdominal lymph nodes, chest radiogram and endoscopic cholangio-pancreatography were unremarkable. Biopsies from the lower duodenum, large intestine, bone marrow and liver showed inflammatory changes with Langhans-type mononuclear granulomas. Together with these findings an increased activity of the angiotensin-converting-enzyme (ACE) indicated sarcoidosis, other causes having been excluded. TREATMENT AND COURSE: All signs and symptoms rapidly improved under prednisolone, and 4 weeks after begin of treatment the biochemical abnormalities had clearly regressed. The raised serum levels of soluble IL-2 receptors and of neopterin, measures of sarcoidosis activity, had decreased. Activity of ACE had fallen. CONCLUSION: Sarcoidosis can present with diverse clinical signs and symptoms. In a case of multi-system disease that cannot be readily classified, sarcoidosis should be included in the differential diagnosis. 相似文献
97.
Rodolfa Emil R.; Vieille Richard; Russell Peter; Nijjer Sukhvender; Nguyen Dao Q.; Mendoza Mary; Perrin Lori 《Canadian Metallurgical Quarterly》1999,30(4):415
As an internship applicant, do you know what internship agencies look for to select or exclude you from further consideration? In a survey, the authors examined exclusion and inclusion criteria used at 402 internship sites accredited by the American Psychological Association (APA). The 249 respondents (62%) rated fit between applicant goals and site opportunities as the most important inclusion criteria. Four exclusion criteria (lack of completion of orals, lack of APA status of doctoral program, poor fit between applicant goals and site opportunities, and incomplete doctoral course work) were most commonly used to eliminate applicants from consideration. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
98.
99.
Synthesis, absolute configuration, and analysis of malathion, malaoxon, and isomalathion enantiomers
Syntheses of the enantiomers of malathion, malaoxon, and isomalathion are reported herein. Malathion enantiomers were prepared from (R)- or (S)-malic acid in three steps. Enantiomers of malathion were converted to the corresponding enantiomers of malaoxon in 52% yield by oxidation with monoperoxyphthalic acid, magnesium salt. The four isomalathion stereoisomers were prepared via two independent pathways using strychnine to resolve the asymmetric phosphorus moiety. The absolute configurations of the four stereoisomers of isomalathion were determined by X-ray crystallographic analysis of an alkaloid salt precursor. A high-performance liquid chromatography technique was developed to resolve the four stereoisomers of isomalathion, and to determine their stereoisomeric ratios. 相似文献
100.
Didier Perrin Céline Guillermain Anne Bergeret José-Marie Lopez-Cuesta Gilles Tersac 《Journal of Materials Science》2006,41(12):3593-3602
A new process of management of waste of composite materials from Sheet Moulding Compounds (SMC), as reinforcing fillers for
thermoplastic materials, including both mechanical and chemical processes is proposed in this paper. Communited SMC being
composed of coated glass fibres intimately mixed with calcium carbonate powder, their reinforcing power is low. First, the
fibrous part was increased by partial dissolution of calcium carbonate present in the crushed products SMC. Second, a process
of partial solvolysis was developed aiming at strong increasing the interfacial mechanical properties by functionalising of
SMC load incorporated into polypropylene/grafted maleic anhydride polypropylene (PP/PPgma). At this effect, we investigated a treatment with a hot triamine (diethylenetriamine, DETA) in order to create a functionalisation,
after scission of the bond ester of unsaturated polyester, as bridging amino-succinimide.The effect of this recycling way
by partial solvolysis was checked from the mechanical properties of the resulting reinforced PP/PPgma material: Although a lower of Young modulus, better yield stress and especially resilience were observed. 相似文献