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The present study was designed to investigate the type and extent of degeneration occurring in the human central auditory system subsequent to profound hearing loss. The authors have examined the size of one population of neurons in the ventral cochlear nucleus in seven subjects with profound hearing loss (audiometric responses poorer than 90-100 dB HL). Six normal subjects, ages 35-78, were used as controls. Cell size in the hearing-impaired subjects ranged from normal to reduced by more than 50 percent. Two factors appear to contribute to the variability in cell size reduction. The correlation coefficient (Spearman rs) of cell size with duration of profound deafness was -0.48, indicating a moderate tendency for neurons to become smaller with longer periods of deafness. The correlation coefficient of cell size with number of surviving cochlear ganglion cells was 0.73, indicating a stronger tendency for neurons to be larger with greater eighth nerve innervation of the cochlear nucleus. Two cases of Scheibe degeneration showed the most severe degenerative change in the central auditory system. 相似文献
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DW Morck JK Merrill BE Thorlakson ME Olson LV Tonkinson JW Costerton 《Canadian Metallurgical Quarterly》1993,202(2):273-277
The prophylactic administration of injectable tilmicosin for pneumonia in weaned beef calves was investigated in 1,806 animals. Comparisons were made among calves receiving an "on-arrival" injection of tilmicosin, calves receiving a single injection of long-acting oxytetracycline, and calves receiving no prophylaxis. Morbidity and mortality attributable to pneumonia, morbidity and mortality attributable to all causes, and case fatality were significantly lower in the group of calves that received tilmicosin, compared with calves that received long-acting oxytetracycline and calves that received no prophylactic antibiotic. Mean time to initial pneumonia treatment was significantly extended in calves that received prophylaxis, compared with those that received no antibiotic on arrival at the feedlot. Calves that received tilmicosin gained significantly more weight than calves that received oxytetracycline. Calves that were not treated for pneumonia during the trial period gained significantly more weight than did those calves that were treated for pneumonia regardless of experimental group. The majority of mortalities were attributable to fibrinous pneumonia (31/34). Important bacterial isolates (Pasteurella spp, Haemophilus somnus, Actinomyces pyogenes) obtained at necropsy did not have resistance to tilmicosin in association with administration of tilmicosin as prophylaxis for pneumonia. However, bacterial resistance to trimethoprim/sulfonamide and to oxytetracycline were commonly found in these postmortem isolates. 相似文献
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David Harbottle Simon Biggs Michael Fairweather 《American Institute of Chemical Engineers》2011,57(7):1693-1699
Streamwise turbulence intensities of fine particulate suspensions were studied in a 26 mm N.B. horizontal pipe loop. Colloidal silica spheres were prepared in 10?4M and 1M KNO3 solutions to control the degree of aggregate formation in the suspension. Using an ultrasonic Doppler velocity profiling sensor, the turbulence intensities of the fine particle suspensions were compared with those of a particle‐free flow over a range of Reynolds numbers. At low electrolyte concentration, the silica particles remain dispersed, with the turbulence intensity of the suspension flow comparable with that of the particle‐free flow. At high electrolyte concentration, increased particle‐particle interaction leads to the formation of particle aggregates which support turbulence augmentation over a critical Reynolds number range. The range of Reynolds numbers over which this turbulence enhancement is observed is limited by both fluid dynamic effects at low Reynolds numbers (Re ≈ 5500) and aggregate breakup at high Reynolds numbers (Re ≈ 8000). © 2010 American Institute of Chemical Engineers AIChE J, 2011 相似文献
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Richard Caulkin Xiaodong Jia Michael Fairweather Richard A. Williams 《American Institute of Chemical Engineers》2012,58(5):1503-1512
For beds comprised randomly arranged nonspherical particles, the prediction and understanding of the packing characteristics and subsequent fluid flow through the resulting porous media is a longstanding problem for chemical and process engineers. This paper presents the application of a digital modeling approach to particle packing, in which no more than elementary physical concepts are used, with the model using collision points to predict trends in bed structures of particles of different geometry. Lattice Boltzmann modeling (LBM), coupled to the output of the packing model, is used to subsequently assess velocity distribution through the generated structures. Simulation results are compared with data available from the literature, as a means of model validation, where it is demonstrated that the combined approach of the digital packing algorithm and LBM provide a modeling capability that is of value to a range of engineering applications. © 2011 American Institute of Chemical Engineers AIChE J, 2012 相似文献