MicroRNAs as Potential Biomarkers in the Differential Diagnosis of Lipomatous Tumors and Their Mimics

Adipocytic tumors are the most common subtype of soft tissue tumors. In current clinical practice, distinguishing benign lipomas from well-differentiated liposarcomas (WDLPS), as well as dedifferentiated liposarcomas (DDLPS) from their morphologic mimics, remains a significant diagnostic challenge. This is especially so when examining small biopsy samples and without the aid of additional ancillary tests. Recognizing the important role that microRNAs (miRNAs) play in tumorigenesis and their potential utility in tumor classification, we analyzed routine clinical tissue samples of benign and malignant lipomatous tumors, as well as other sarcoma mimics, to identify distinguishing miRNA-based signatures that can aid in the differential diagnosis of these entities. We discovered a 6-miRNA signature that separated lipomas from WDLPS with high confidence (AUC of 0.963), as well as a separate 6-miRNA signature that distinguished DDLPS from their more aggressive histologic mimics (AUC of 0.740). Functional enrichment analysis unveiled possible mechanistic involvement of these predictive miRNAs in adipocytic cancer-related biological processes and pathways such as PI3K/AKT/mTOR and MAPK signaling, further supporting the relevance of these miRNAs as biomarkers for adipocytic tumors. Our results demonstrate that miRNA expression profiling may potentially be used as an adjunctive tool for the diagnosis of benign and malignant adipocytic tumors. Further validation studies are warranted.     

Mutated KIT Tyrosine Kinase as a Novel Molecular Target in Acute Myeloid Leukemia

KIT is a type-III receptor tyrosine kinase that contributes to cell signaling in various cells. Since KIT is activated by overexpression or mutation and plays an important role in the development of some cancers, such as gastrointestinal stromal tumors and mast cell disease, molecular therapies targeting KIT mutations are being developed. In acute myeloid leukemia (AML), genome profiling via next-generation sequencing has shown that several genes that are mutated in patients with AML impact patients’ prognosis. Moreover, it was suggested that precision-medicine-based treatment using genomic data will improve treatment outcomes for AML patients. This paper presents (1) previous studies regarding the role of KIT mutations in AML, (2) the data in AML with KIT mutations from the HM-SCREEN-Japan-01 study, a genome profiling study for patients newly diagnosed with AML who are unsuitable for the standard first-line treatment (unfit) or have relapsed/refractory AML, and (3) new therapies targeting KIT mutations, such as tyrosine kinase inhibitors and heat shock protein 90 inhibitors. In this era when genome profiling via next-generation sequencing is becoming more common, KIT mutations are attractive novel molecular targets in AML.     

用于直角电桥的数字信号发生器的设计

根据直角电桥的比例臂要求,设计并实现了一种基于FPGA和DDS技术的直角电压源,所设计直角电压源可用于直角阻抗的比较,并通过实验的方法给出了作为比例臂时的相对稳定性等指标.     

基于AHM和ABC分类法的多元过程能力指数

简要介绍了多元质量特性的过程能力指数(MPCI)的研究现状,并提出基于AHM(属性层次模型)和ABC分类法的多元过程能力指数。该方法充分考虑了各个质量特性的重要性差异和不同等级的质量特性的控制目标的不同。具体介绍了该方法的步骤,并通过实例分析证明了方法的有效性和实际性。     

A physics-based simulation approach for cooperative erection activities

Cooperative erection activities are critical to projects which involve the erection of heavy loads or the installation of special equipment. Detailed simulation on computer prior to construction can identify constructability problems, and subsequently avoided during actual erections. This paper describes an integrated approach for simulating the detailed motions of cranes. This research develops a physics-based model that follows the principle of closed-form forward kinematics and constraint-based dynamics to present the dual-crane mechanism mathematically — a non-trivial task. This model can be used to analyze the inputs from the users (i.e. virtual crane operators) and simultaneously compute the cables sway and reaction of collisions. We also implemented the model on computer and developed a simulation system, Erection Director, to render realistic cooperative erection activities. A demonstration of simulating two-crane lift has been built and three performance tests including a small building (840 elements), a medium building (1937 elements) and a large building (2682 elements) validate the feasibility of the proposed approach. The test results indicate that Erection Director can support real-time and physics-based visualization of cooperative erections.     

改进的集对分析水质综合评价方法

针对标准集对分析存在的同异反评语细化问题,利用原创联系度可展性对其进行改进,并建立了地表水水质评价模型,可以得到评价样本对于各水质评价等级的优劣趋同程度。并与模糊评价相结合应用于山西省地表水质评价,并引入差异系数来优化评价指标体系,利用熵权系数法和超标倍数赋权法求得指标的综合权重。将评价结果与灰色聚类法、综合指标法、模糊神经网络法和投影寻踪法的评价结果进行比较,结果表明：改进后的的集对分析评价结果更贴近实际情况,为水环境分析提供了一种更为科学、合理的评价和决策方法,具有良好的应用前景。     

Amplifier linearization using compact microstrip resonant cell-theory and experiment

This paper presents a novel technique for reducing the intermodulation distortions (IMDs) in power amplifiers. In this method, both second- and third-harmonic components generated by the transistor are reflected back simultaneously by the compact microstrip resonant cell (CMRC) at the input port with proper phases to mix with the fundamental signal for the reduction of IMDs. A rigorous mathematical analysis on the effectiveness of multiharmonic reflections has been formulated and derived using the Volterra series. Moreover, the delay mismatch factor of the proposed method is analytically studied and the result shows that a better tolerance to the delay error can be achieved by using CMRC circuitry. Standard two-tone test measurements reveal 32- and 22-dB reductions for the third-order IMD and fifth-order IMD, respectively, without affecting the fundamental signal at 2.45 GHz. Meanwhile, the proposed approach gives a peak power added efficiency of 53% with 11.5 dB transducer gain and 15 dBm output power for a single-stage SiGe bipolar junction transistor. The adjacent channel power ratio (ACPR) is -55dBc for a data rate of 384-kb/s quadrature phase shift keyed modulated signal with 2-MHz spanning bandwidth, and this ACPR is maintained for a broad range of output power level.     

Unprecedented Homoleptic Bis‐Tridentate Iridium(III) Phosphors: Facile,Scaled‐Up Production,and Superior Chemical Stability

Bis‐tridentate Ir(III) metal complexes are expected to show great potential in organic light‐emitting diode (OLED) applications due to the anticipated, superb chemical and photochemical stability. Unfortunately, their exploitation has long been hampered by lack of adequate methodology and with inferior synthetic yields. This hurdle can be overcome by design of the first homoleptic, bis‐tridentate Ir(III) complex [Ir(pzpyph)(pz^Hpyph)] ( 1 ), for which the abbreviation (pzpyph)H (or pz^Hpyph) stands for the parent 2‐pyrazolyl‐6‐phenyl pyridine chelate. After that, methylation and double methylation of 1 afford the charge‐neutral Ir(III) complex [Ir(pzpyph)(pz^Mepyph)] ( 2 ) and cationic complex [Ir(pz^Mepyph)₂][PF₆] ( 3 ), while deprotonation of 1 gives formation of anionic [Ir(pzpyph)₂][NBu₄] ( 4 ), all in high yields. These bis‐tridentate Ir(III) complexes 2 – 4 are highly emitted in solution and solid states, while the charge‐neutral 2 and corresponding t ‐butyl substituted derivative [Ir(pzpy^Buph)(pz^Mepy^Buph)] ( 5 ) exhibit superior photostability versus the tris‐bidentate references [Ir(ppy)₂(acac)] and [Ir(ppy)₃] in toluene under argon, making them ideal OLED emitters. For the track record, phosphor 5 gives very small efficiency roll‐off and excellent overall efficiencies of 20.7%, 66.8 cd A^?1, and 52.8 lm W^?1 at high brightness of 1000 cd m^?2. These results are expected to inspire further studies on the bis‐tridentate Ir(III) complexes, which are judged to be more stable than their tris‐bidentate counterparts from the entropic point of view.     

Hydrogen‐Bonding‐Assisted Intermolecular Charge Transfer: A New Strategy to Design Single‐Component White‐Light‐Emitting Materials

This study reveals the mechanism of the dual‐emission properties for asymmetrical diphenylsulfone and diphenylketone derivatives. A series of asymmetrical diphenylketone and diphenylsulfone derivatives with dual‐emission properties are designed and synthesized. By single crystal structure analyses, various photophysical studies, and 2D ¹H–¹H NOSEY NMR studies, the lower energy emission bands in the dual‐emission spectra are successfully assigned to hydrogen‐bonding‐assisted intermolecular charge transfer emission. The emission properties of these compounds can easily be tuned in both solid state and solution state by destroying or strengthening the intermolecular hydrogen bonding. In addition, thermally activated delayed fluorescence characteristics for the intermolecular charge transfer emissions are also observed. The control of the intermolecular and intramolecular charge transfers serves as the basis for the generation of the white‐light emission. For compound CPzPO, nearly pure white‐light emission with CIE coordinates of (0.31, 0.32) is easily achieved by precipitation from dichloromethane and hexane mixed solvent system. These results clearly give an insight into the dual‐emission properties and provide a rational strategy for the design and synthesis of single‐component white‐light‐emitting materials and mechanoresponsive light‐emitting materials.