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111.
Deniau G Slawin AM Lebl T Chorki F Issberner JP van Mourik T Heygate JM Lambert JJ Etherington LA Sillar KT O'Hagan D 《Chembiochem : a European journal of chemical biology》2007,8(18):2265-2274
Gamma-aminobutyric acid or GABA (1) is one of the major inhibitory amino acid neurotransmitters of the central nervous system. This article describes the first synthesis of both the (R)- and (S)- enantiomers of 3-fluoro-GABA (2, 3F-GABA). DFT calculations were carried out in a continuum solvent model (PCM-B3LYP) to estimate the preferred conformations of 3F-GABA in aqueous solution. NMR coupling constants were calculated for each conformer and were then used to simulate the NMR spectra to evaluate the solution conformation of 3F-GABA. A preliminary evaluation of the 3F-GABA enantiomers shows that they act similarly as agonists of cloned GABA(A) receptors; however, they behave quite differently in a whole animal (Xenopus laevis tadpole model). 相似文献
112.
AbstractWastewater generated from the conventional pretreatment process is having potential to reuse several times for pretreatment of subsequent batches without harming the fabric quality. As the major portion of water is used in textile pretreatment processes, in the present work a novel method was studied for direct reuse of wastewater in combining scouring and bleaching process. The wastewater generated by the conventional pretreatment was reused with and without mixing with freshwater. Simple technique like filtration with nylon mesh was also studied for its effects on efficiency of pretreatment. The pretreated fabrics were characterized using advanced techniques and further evaluated towards efficiency of scouring and bleaching. In order to evaluate the effect of novel pretreatment process involving reuse of wastewater on dyeability, the pretreated fabrics (using both conventional and novel methods) were further studied for dyeability using reactive dyes. The resulting wastewaters were characterized before reuse in novel method. The pretreated fabrics showed insignificant variations in strength and pretreatment efficiency. The dyeability of both fabrics towards reactive dyes was comparable. The volume of effluent generated was greatly reduced in novel method which showed a great promise to save 33% of water in pretreatment process of cotton fabric. 相似文献
113.
114.
The present contribution determines the impacts of viscous dissipation and Ohmic heating with magnetic coating on Prandtl nanofluid flow driven by an unsteady bidirectionally moveable surface. Random motion of nanoparticles and thermophoretic diffusion are elaborated through a two-phase nanofluid model. The novelty of the investigation is fortified by prescribed heat flux and prescribed mass flux mechanisms. The appropriate combination of variables leads to a system of strong nonlinear ordinary differential equations. The formulated nonlinear system is then tackled by an efficient numerical scheme, namely, the Keller–Box method. Nanoliquid-temperature and mass-concentration distributions are conferred through various plots with the impacts of miscellaneous-arising parameters. The rates of heat and mass transferences are also discussed through tables. The thermal states of the nanomaterial and mass concentration are reduced for incremental amounts of the unsteady factor, ratio parameter, elastic parameter, and Prandtl fluid parameter. Moreover, escalating amounts of the Brownian parameter, Eckert number, magnetic factor, and thermophoresis parameter enhances the temperature of the nanoliquid. An error analysis is also presented to predict the efficiency of the method used for the computational work. 相似文献
115.
Thomas Pel Sebastien Giraud Sandrine Joffrion Virginie Ameteau Adriana Delwail Jean-Michel Goujon Laurent Macchi Thierry Hauet Fatima Dkhissi Omar Benzakour 《International journal of molecular sciences》2021,22(22)
Renal ischaemia reperfusion (I/R) triggers a cascade of events including oxidative stress, apoptotic body and microparticle (MP) formation as well as an acute inflammatory process that may contribute to organ failure. Macrophages are recruited to phagocytose cell debris and MPs. The tyrosine kinase receptor MerTK is a major player in the phagocytosis process. Experimental models of renal I/R events are of major importance for identifying I/R key players and for elaborating novel therapeutical approaches. A major aim of our study was to investigate possible involvement of MerTK in renal I/R. We performed our study on both natural mutant rats for MerTK (referred to as RCS) and on wild type rats referred to as WT. I/R was established by of bilateral clamping of the renal pedicles for 30′ followed by three days of reperfusion. Plasma samples were analysed for creatinine, aspartate aminotransferase (ASAT), lactate dehydrogenase (LDH), kidney injury molecule -1 (KIM-1), and neutrophil gelatinase-associated lipocalin (NGAL) levels and for MPs. Kidney tissue damage and CD68-positive cell requirement were analysed by histochemistry. monocyte chemoattractant protein-1 (MCP-1), myeloperoxidase (MPO), inducible nitric oxide synthase (iNOS), and histone 3A (H3A) levels in kidney tissue lysates were analysed by western blotting. The phagocytic activity of blood-isolated monocytes collected from RCS or WT towards annexin-V positive bodies derived from cultured renal cell was assessed by fluorescence-activated single cell sorting (FACS) and confocal microscopy analyses. The renal I/R model for RCS rat described for the first time here paves the way for further investigations of MerTK-dependent events in renal tissue injury and repair mechanisms. 相似文献
116.
117.
Shadab Md Nabil A. Alhakamy Waleed S. Alharbi Javed Ahmad Rasheed A. Shaik Ibrahim M. Ibrahim Javed Ali 《International journal of molecular sciences》2021,22(24)
In the present work, novel modality for lung cancer intervention has been explored. Primary literature has established the potential role of cyclooxygenase-2 (COX-2) inhibitor in regression of multiple forms of carcinomas. To overcome its poor water solubility and boost anticancer activity, etoricoxib (ETO) was chosen as a therapeutic candidate for repurposing and formulated into a nanoemulsion (NE). The prepared ETO loaded NE was characterized for the surface charge, droplet size, surface morphology, and in vitro release. The optimized ETO loaded NE was then investigated for its anticancer potential employing A549 lung cancer cell line via cytotoxicity, apoptotic activity, mitochondrial membrane potential activity, cell migration assay, cell cycle analysis, Caspase-3, 9, and p53 activity by ELISA and molecular biomarker analysis through RT-PCR test. The developed ETO-NE formulation showed adequate homogeneity in the droplet size distribution with polydispersity index (PDI) of (0.2 ± 0.03) and had the lowest possible droplet size (124 ± 2.91 nm) and optimal negative surface charge (−8.19 ± 1.51 mV) indicative of colloidal stability. The MTT assay results demonstrated that ETO-NE exhibited substantial anticancer activity compared to the free drug. The ETO-NE showed a substantially potent cytotoxic effect against lung cancer cells, as was evident from the commencement of apoptosis/necrotic cell death and S-phase cell cycle arrests in A549 cells. The study on these molecules through RT-PCR confirmed that ETO-NE is significantly efficacious in mitigating the abundance of IL-B, IL-6, TNF, COX-2, and NF-kB as compared to the free ETO and control group. The current study demonstrates that ETO-NE represents a feasible approach that could provide clinical benefits for lung cancer patients in the future. 相似文献
118.
Weighted Gene Co‐Expression Network Analysis Identifies Gender Specific Modules and Hub Genes Related to Metabolism and Inflammation in Response to an Acute Lipid Challenge
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119.
Evanoff K Khan J Balandin AA Magasinski A Ready WJ Fuller TF Yushin G 《Advanced materials (Deerfield Beach, Fla.)》2012,24(4):533-537
Vapor deposition techniques were utilized to synthesize very thick (~1 mm) Li-ion battery anodes consisting of vertically aligned carbon nanotubes coated with silicon and carbon. The produced anode demonstrated ultrahigh thermal (>400 W·m(-1) ·K(-1)) and high electrical (>20 S·m(-1)) conductivities, high cycle stability, and high average capacity (>3000 mAh·g(Si) (-1)). The processes utilized allow for the conformal deposition of other materials, thus making it a promising architecture for the development of Li-ion anodes and cathodes with greatly enhanced electrical and thermal conductivities. 相似文献
120.
This paper reports results from a comprehensive study of Fe–Ga films fabricated over a wide range of growth conditions. Polycrystalline Fe100?xGax films (14 ? x ? 32) were deposited (using three different combinations of growth parameters) on Si(1 0 0) using a co-sputtering and evaporation technique. The growth parameters (sputter power, Ga evaporation rate and chamber pressure) were used primarily to control the Fe:Ga ratio in the films. X-ray diffraction showed that all films had 〈1 1 0〉 crystallographic texture normal to the film plane. The lattice parameter increased with % Ga up to x = 22 and was independent of growth parameters. Conversion electron Mössbauer spectroscopy studies showed a predominance of the disordered A2 phase in all films. It appears that the use of vacuum deposition with appropriate parameters can effectively suppress the D03 ordered phase. Systematic studies of the effective magnetostriction constant as a function of composition support this conclusion. It was found that films of high effective saturation magnetostriction constant and low stress could be fabricated using low Ar pressure, irrespective of sputter power or evaporation rate, giving properties useful for application in microelectromechanical systems. 相似文献