全文获取类型
收费全文 | 353篇 |
免费 | 34篇 |
国内免费 | 6篇 |
专业分类
电工技术 | 2篇 |
综合类 | 1篇 |
化学工业 | 123篇 |
金属工艺 | 2篇 |
机械仪表 | 15篇 |
建筑科学 | 13篇 |
能源动力 | 12篇 |
轻工业 | 47篇 |
石油天然气 | 2篇 |
无线电 | 37篇 |
一般工业技术 | 69篇 |
冶金工业 | 15篇 |
自动化技术 | 55篇 |
出版年
2024年 | 3篇 |
2023年 | 8篇 |
2022年 | 41篇 |
2021年 | 42篇 |
2020年 | 27篇 |
2019年 | 20篇 |
2018年 | 23篇 |
2017年 | 21篇 |
2016年 | 27篇 |
2015年 | 15篇 |
2014年 | 11篇 |
2013年 | 30篇 |
2012年 | 8篇 |
2011年 | 18篇 |
2010年 | 21篇 |
2009年 | 12篇 |
2008年 | 15篇 |
2007年 | 8篇 |
2006年 | 9篇 |
2005年 | 7篇 |
2004年 | 2篇 |
2003年 | 4篇 |
2002年 | 4篇 |
2000年 | 2篇 |
1998年 | 3篇 |
1997年 | 2篇 |
1996年 | 3篇 |
1995年 | 1篇 |
1994年 | 1篇 |
1993年 | 1篇 |
1990年 | 1篇 |
1988年 | 1篇 |
1985年 | 1篇 |
1975年 | 1篇 |
排序方式: 共有393条查询结果,搜索用时 93 毫秒
241.
242.
243.
Buddhima Indraratna Yujie Qi Rakesh Sai Malisetty Sinniah K.Navaratnarajah Fatima Mehmood Miriam Tawk 《铁道工程科学(英文)》2022,30(3):304-322
Given that the current ballasted tracks in Australia may not be able to support faster and significantly heavier freight trains as planned for the future, the imminent need for innovative and sustainable ballasted tracks for transport infrastructure is crucial. Over the past two decades, a number of studies have been conducted by the researchers of Transport Research Centre(TRC) at the University of Technology Sydney(UTS) to investigate the ability of recycled rubber mats, as well as waste tyre ... 相似文献
244.
245.
Alayn Al-marddyah A. Al-khawalde Mohammad H. Abukhalil Muthana M. Jghef Manal A. Alfwuaires Fatima S. Alaryani Saleem H. Aladaileh Abdulmohsen I. Algefare Shaik Karimulla Fawaz Alasmari Hammad Khalifeh Aldalin Abdulkareem A. Alanezi Osama Y. Althunibat 《International journal of molecular sciences》2022,23(20)
Despite its effectiveness in treating inflammatory diseases and various malignancies, methotrexate (MTX) is well known to cause hepatotoxicity, which involves increased oxidative stress and inflammation, limiting its clinical use. Herein, we looked into the effect of punicalagin (PU), a polyphenolic molecule having a variety of health-promoting attributes, on MTX-induced hepatotoxicity in mice. PU (25 and 50 mg/kg/day) was given orally to the mice for 10 days, while a single dose of MTX (20 mg/kg) was injected intraperitoneally (i.p.) at day 7. The MTX-induced liver damage was demonstrated by remarkably higher transaminases (ALT and AST), ALP, and LDH, as well as significant histological alterations in hepatic tissues. MTX-injected mice also demonstrated increases in hepatic oxidative stress markers, including malondialdehyde (MDA) and nitric oxide (NO), with a concordant drop in glutathione (GSH) content and superoxide dismutase (SOD) and catalase (CAT) activities. PU significantly attenuated the MTX-induced serum transaminases, ALP and LDH elevations, and hepatic oxidative stress measures and boosted antioxidant defenses in the liver. Moreover, the liver of MTX-treated mice showed increases in NF-κB p65 expression, pro-inflammatory cytokine (IL-6 and TNF-α) levels, and pro-apoptotic protein (caspase-3 and Bax) expression, whereas Bcl-2 and Nrf2 expressions were reduced, which were all attenuated by PU treatment. Collectively, PU inhibits oxidative damage, inflammation, and apoptosis and upregulates Nrf2 in the liver of MTX-induced mice. Thus, these findings suggest that PU may have great therapeutic potential for the prevention of MTX-induced hepatotoxicity, pending further exploration in upcoming studies. 相似文献
246.
Dr. Jennifer A. Miles Dr. Fruzsina Hobor Dr. Chi H. Trinh James Taylor Dr. Christian Tiede Dr. Philip R. Rowell Dr. Brian R. Jackson Fatima A. Nadat Pallavi Ramsahye Dr. Hannah F. Kyle Dr. Basile I. M. Wicky Prof. Jane Clarke Dr. Darren C. Tomlinson Prof. Andrew J. Wilson Dr. Thomas A. Edwards 《Chembiochem : a European journal of chemical biology》2021,22(1):232-240
Abstract : The BCL-2 family is a challenging group of proteins to target selectively due to sequence and structural homologies across the family. Selective ligands for the BCL-2 family regulators of apoptosis are useful as probes to understand cell biology and apoptotic signalling pathways, and as starting points for inhibitor design. We have used phage display to isolate Affimer reagents (non-antibody-binding proteins based on a conserved scaffold) to identify ligands for MCL-1, BCL-xL, BCL-2, BAK and BAX, then used multiple biophysical characterisation methods to probe the interactions. We established that purified Affimers elicit selective recognition of their target BCL-2 protein. For anti-apoptotic targets BCL-xL and MCL-1, competitive inhibition of their canonical protein-protein interactions is demonstrated. Co-crystal structures reveal an unprecedented mode of molecular recognition; where a BH3 helix is normally bound, flexible loops from the Affimer dock into the BH3 binding cleft. Moreover, the Affimers induce a change in the target proteins towards a desirable drug-bound-like conformation. These proof-of-concept studies indicate that Affimers could be used as alternative templates to inspire the design of selective BCL-2 family modulators and more generally other protein-protein interaction inhibitors. 相似文献
247.
248.
Ramon van der Vlag M. Yagiz Unver Dr. Tommaso Felicetti Dr. Aleksandra Twarda-Clapa Fatima Kassim Cagdas Ermis Dr. Constantinos G. Neochoritis Dr. Bogdan Musielak Beata Labuzek Prof. Dr. Alexander Dömling Prof. Dr. Tad A. Holak Prof. Dr. Anna K. H. Hirsch 《ChemMedChem》2020,15(4):370-375
Innovative and efficient hit-identification techniques are required to accelerate drug discovery. Protein-templated fragment ligations represent a promising strategy in early drug discovery, enabling the target to assemble and select its binders from a pool of building blocks. Development of new protein-templated reactions to access a larger structural diversity and expansion of the variety of targets to demonstrate the scope of the technique are of prime interest for medicinal chemists. Herein, we present our attempts to use a protein-templated reductive amination to target protein-protein interactions (PPIs), a challenging class of drug targets. We address a flexible pocket, which is difficult to achieve by structure-based drug design. After careful analysis we did not find one of the possible products in the kinetic target-guided synthesis (KTGS) approach, however subsequent synthesis and biochemical evaluation of each library member demonstrated that all the obtained molecules inhibit MDM2. The most potent library member (Ki=0.095 μm ) identified is almost as active as Nutlin-3, a potent inhibitor of the p53-MDM2 PPI. 相似文献
249.
250.
Urooj Fatima Shakaib M. Memon Inayatullah 《Theoretical Foundations of Chemical Engineering》2021,55(3):426-438
Theoretical Foundations of Chemical Engineering - This work includes a 3D computational fluid dynamics study on rectangular-shaped micromixers. Initially, T-shaped micromixer types are considered... 相似文献