Prediction of industrial debutanizer column compositions using data-driven ANFIS- and ANN-based approaches

Neural Computing and Applications - The work in this paper is based on an industrial debutanizer column in a petroleum refinery located in Malaysia, which produces LPG (liquefied petroleum gas) as...     

A contribution to improvement of the nuclear data concerning alpha decay of U

Compared to other alpha-particle emitting nuclides, for those with long half-lives (T_1/2>10⁶ years), there is generally some inconsistency and inaccuracy in the associated nuclear data. However, these radionuclides play a major role in modern society and, for a number of reasons, are the subject of widespread interest. The study of their alpha decay, which is more difficult than in the case of the other nuclides, enables knowledge of their nuclear data to be increased. In the present paper, we accordingly consider one of the most well known ones: ²³⁵U. Using a quasi mono-isotopic deposit of ²³⁵U obtained by electromagnetic separation, we have studied the alpha-particle decay of ²³⁵U using a high-energy resolution spectrometer developed in our laboratory. The stability of the spectrometer made it possible to perform long measurements which is crucial in the case of ²³⁵U. The Colégram program, with a new fit criterion to better take into account peaks of low statistical significance, was used to extract the data (alpha-particle emission probabilities and energies). Monte-Carlo simulations carried out in the context of this work were also used to corroborate the data obtained. Finally, thirteen alpha-particle emissions from ²³⁵U were measured, from which only ten were previously observed and measured. This work has substantially reduced the uncertainty concerning alpha-particle emission probability and energy values and has resolved some of the ambiguities concerning the ²³⁵U disintegration scheme to ²³¹Th.     

The prevalence of rheumatoid arthritis in affluent and poor urban communities of Pakistan

Using previously applied methods a survey of joint symptoms was undertaken among 4232 adults, evenly distributed between affluent and poor areas of Karachi, Pakistan. Only six cases of definite rheumatoid arthritis (RA) (1958 ARA criteria) were identified in the 245 persons who complained of joint problems of at least 4 weeks duration. The prevalence was 0.9 [confidence interval (CI) 0.21-3.61] and 1.98 (CI 0.55-5.1) per thousand in the poor and affluent districts, respectively. These were substantially less than prevalence rates reported in the West but were similar to figures derived from other developing countries. There was no obvious impact of current living standards on the findings. The relative paucity of older female subjects in both the affluent and poor communities may account at least in part for the low rates observed. The infrequency of rheumatoid nodules in Southern Asians with RA illustrates the difficulty of applying existing diagnostic criteria to this community.     

Metabolomics profiling of xenobiotics in elite athletes: relevance to supplement consumption

Background

Supplements are widely used among elite athletes to maintain health and improve performance. Despite multiple studies investigating use of dietary supplements by athletes, a comprehensive profiling of serum supplement metabolites in elite athletes is still lacking. This study aims to analyze the presence of various xenobiotics in serum samples from elite athletes of different sports, focusing on metabolites that potentially originate from nutritional supplements.

Methods

Profiling of xenobiotics in serum samples from 478 elite athletes from different sports (football, athletics, cycling, rugby, swimming, boxing and rowing) was performed using non-targeted metabolomics-based mass spectroscopy combined with ultrahigh-performance liquid chromatography. Multivariate analysis was performed using orthogonal partial least squares discriminant analysis. Differences in metabolic levels among different sport groups were identified by univariate linear models.

Results

Out of the 102 detected xenobiotics, 21 were significantly different among sport groups including metabolites that potentially prolong exercise tolerance (caffeic acid), carry a nootropic effect (2-pyrrolidinone), exert a potent anti-oxidant effect (eugenol, ferulic acid 4 sulfate, thioproline, retinol), or originate from drugs for different types of injuries (ectoine, quinate). Using Gaussian graphical modelling, a metabolic network that links various sport group-associated xenobiotics was constructed to further understand their metabolic pathways.

Conclusions

This pilot data provides evidence that athletes from different sports exhibit a distinct xenobiotic profile that may reflect their drug/supplement use, diet and exposure to various chemicals. Because of limitation in the study design, replication studies are warranted to confirm results in independent data sets, aiming ultimately for better assessment of dietary supplement use by athletes.

     

Resveratrol Interferes with an Early Step in the Fibrillization Pathway of Human Lysozyme and Modulates it towards Less‐Toxic,Off‐Pathway Aggregates

The effect of resveratrol, a polyphenol in red wine, on the amyloid fibril formation of human lysozyme (HuL) was investigated, towards elucidating the mechanism of resveratrol action and probing its role as a possible modulator of lysozyme aggregation and toxicity. By using a number of biophysical tools, resveratrol was observed to alter the fibrillization kinetics of HuL and inhibit its fibrillization by binding with weak to moderate affinity to the conformations populated at the early stages of the pathway with concomitant stabilization of these initial conformations. The marginal decrease in the lifetime of HuL in the presence of resveratrol by time‐resolved fluorescence measurements indicated the involvement of a static quenching mechanism in the interaction between HuL and resveratrol. Docking studies predicted the binding of resveratrol to aggregation‐prone regions in HuL, and structure and activity analyses demonstrated the retention of much of the α‐helical structure and activity of HuL in the presence of resveratrol. Resveratrol modulated the fibrillization pathway towards less‐hydrophobic, less‐toxic, off‐pathway aggregates. These results demonstrate that binding of resveratrol to HuL could protect against the formation of pathogenic, cytotoxic aggregates formed in amyloidogenic disorders, such as systemic amyloidosis; thus suggesting its potential as a plausible therapeutic agent against lysozyme amyloidosis.     

High Performance p‐ and n‐Type Light‐Emitting Field‐Effect Transistors Employing Thermally Activated Delayed Fluorescence

Light‐emitting field‐effect transistors (LEFETs) are an emerging type of devices that combine light‐emitting properties with logical switching function. One of the factors limiting their efficiency stems from the spin statistics of electrically generated excitons. Only 25% of them, short lived singlet states, are capable of light emission, with the other 75% being long lived triplet states that are wasted as heat due to spin‐forbidden processes. Traditionally, the way to overcome this limitation is to use phosphorescent materials as additional emission channel harnessing the triplet excitons. Here, an alternative strategy for triplet usage in LEFETs in the form of thermally activated delayed fluorescence (TADF) is presented. Devices employing a TADF capable material, 4CzIPN (2,4,5,6‐tetra[9H‐carbazol‐9‐yl]isophthalonitrile), in both n‐type and p‐type configurations are shown. They manifest excellent electrical characteristics, consistent brightness in the range of 100–1,000 cd m^‐2 and external quantum efficiency (EQE) of up to 0.1%, which is comparable to the equivalent organic light‐emitting diode (OLED) based on the same materials. Simulation identifies the poor light out‐coupling as the main reason for lower than expected EQEs. Transmission measurements show it can be partially alleviated using a more transparent top contact, however more structural optimization is needed to tap the full potential of the device.     

Non-destructive Microstructural Evaluation of Intact and Restored Human Teeth Using Tabletop X-Ray $$\upmu $$CT System

This study explores the feasibility of a micro-focus based tabletop X-ray \(\upmu \)CT system for the micro-structural characterization of human teeth and later its application to the non-destructive evaluation of teeth restored with different composite resin for their interface integrity and micro-imperfections. In the first part of this study, extracted human primary and permanent molar teeth were used to explore potential of micro-focus based tomography setup for their micro-structural characterization. The details of root canal structure of human teeth were visualized and quantified with polychromatic \(\upmu \)CT. In the second part identification and comparison of defects in a set of six human teeth samples, which were restored with two different composite resins, was carried out. Group ‘A’ samples were restored using a submicron hybrid composite material and Group ‘B’ were restored with a Nano-hybrid restorative composite material. The quantitative analysis of \(\upmu \)CT data for composite resin restored teeth showed more number of voids or defects in Group ‘A’ restorations compared to Group ‘B’. A comparative evaluation of \(\upmu \)CT techniques based on synchrotron source and micro-focus source is also illustrated to show their respective merits and limitations.     

Enhanced Electroluminescence from Organic Light‐Emitting Diodes with an Organic–Inorganic Perovskite Host Layer

The development of host materials with high performance is essential for fabrication of efficient and stable organic light‐emitting diodes (OLEDs). Although host materials used in OLEDs are typically organics, in this study, it is shown that the organic–inorganic perovskite CH₃NH₃PbCl₃ (MAPbCl₃) can be used as a host layer for OLEDs. Vacuum‐evaporated MAPbCl₃ films have a wide band gap of about 3 eV and very high and relatively balanced hole and electron mobilities, which are suitable for the host material. Photoluminescence and electroluminescence take place through energy transfer from MAPbCl₃ to an organic emitter in films. Incorporation of an MAPbCl₃ host layer into OLEDs leads to a reduction of driving voltage and enhancement of external quantum efficiency as compared to devices with a conventional organic host layer. Additionally, OLEDs with an MAPbCl₃ host layer demonstrate very good operational stability under continuous current operation. These results can be extensively applied to organic‐ and perovskite‐based optoelectronics.     

Adaptive Nonlinear Control of Wind Energy Conversion System Involving Induction Generator

This paper presents a theoretical framework for adaptive control of a wind energy conversion system (WECS), involving a squirrel cage induction generator (SIG) connected with an AC/DC/AC IGBT‐based PWM converter. A multi‐loop nonlinear controller is designed to meet two main control objectives, i.e., (i) speed reference optimization in order to extract a maximum wind energy whatever the wind speed, and (ii) power factor correction (PFC) to avoid net harmonic pollution. These objectives must be achieved despite the mechanical parameters uncertainty. First, a nonlinear model of the whole controlled system is developed within the Park coordinates. Then, a multi‐loop nonlinear controller is synthesized using the adaptive backstepping design. A formal analysis based on Lyapunov stability is carried out to describe the control system performances. In addition to closed‐loop global asymptotic stability, it is proven that all control objectives (induction generator speed tracking, rotor flux regulation, DC link voltage regulation and unitary power factor) are asymptotically achieved.