Decoupled approach to integrated optimum design of structures and robust control systems

Integrated optimum design of structures and control systems is studied by using H ₂ and robust control formulations. It is derived that conventional simultaneous optimization approach by using these robust control laws can be approximated by a decoupled optimization approach in which the structures are optimized by shaping the structural singular values and then the controllers can be designed, namely, decoupled, sequential or successive design approach. It is shown that the proposed decoupled optimization approach can be used to design optimum robust structures and has certain advantages over the conventional simultaneous optimization procedures such as it avoids the drawbacks of pure robust control laws and faster, especially if the number of degrees of freedom (DOF) of the associated structure is large. The bounds for achievable robustness measures are also obtained. Following, simultaneous and decoupled optimization approaches are applied to active control of two structures. The optimization results are presented, and it is concluded that the proposed decoupled optimization approach yields the achieved global minimum much faster than the simultaneous optimization approach.     

A new supervised classification algorithm in artificial immune systems with its application to carotid artery Doppler signals to diagnose atherosclerosis

Because of its self-regulating nature, immune system has been an inspiration source for usually unsupervised learning methods in classification applications of Artificial Immune Systems (AIS). But classification with supervision can bring some advantages to AIS like other classification systems. Indeed, there have been some studies, which have obtained reasonable results and include supervision in this branch of AIS. In this study, we have proposed a new supervised AIS named as Supervised Affinity Maturation Algorithm (SAMA) and have presented its performance results through applying it to diagnose atherosclerosis using carotid artery Doppler signals as a real-world medical classification problem. We have employed the maximum envelope of the carotid artery Doppler sonograms derived from Autoregressive (AR) method as an input of proposed classification system and reached a maximum average classification accuracy of 98.93% with 10-fold cross-validation method used in training-test portioning. To evaluate this result, comparison was done with Artificial Neural Networks and Decision Trees. Our system was found to be comparable with those systems, which are used effectively in literature with respect to classification accuracy and classification time. Effects of system's parameters were also analyzed in performance evaluation applications. With this study and other possible contributions to AIS, classification algorithms with effective performances can be developed and potential of AIS in classification can be further revealed.     

Combining docking, scoring and molecular field analyses to probe influenza neuraminidase-ligand interactions

In this project, several docking conditions, scoring functions and corresponding protein-aligned molecular field analysis (CoMFA) models were evaluated for a diverse set of neuraminidase (NA) inhibitors. To this end, a group of inhibitors were docked into the active site of NA. The docked structures were utilized to construct a corresponding protein-aligned CoMFA models by employing probe-based (H+, OH, CH3) energy grids and genetic partial least squares (G/PLS) statistical analysis. A total of 16 different docking configurations were evaluated, of which some succeeded in producing self-consistent and predictive CoMFA models. However, the best model coincided with docking the ionized ligands into the hydrated form of the binding site via PLP1 scoring function (r2LOO=0.735, r2PRESS against 24 test compounds=0.828). The highest-ranking CoMFA models were employed to probe NA-ligand interactions. Further validation by comparison with a co-crystallized ligand-NA crystallographic structure was performed. This combination of docking/scoring/CoMFA modeling provided interesting insights into the binding of different NA inhibitors.     

Tree-systems of morphisms

Starting from the idea of determinism in membrane systems, we introduce a language generating device consisting of morphisms placed in the nodes of a tree. Initial strings are given in the leaves; by iteratively applying the morphisms to them, we produce new strings, which are collected in the root of the tree. Such a device is called a tree-system of morphisms (in short, a T system). We investigate here the power of T systems, both in the extended (a terminal alphabet is considered and only strings over it are accepted) and non-extended case, mainly in comparison with classes of languages in Lindenmayer hierarchy. Received: 8 February 2001 / 18 September 2001     

Clustering of high throughput gene expression data

High throughput biological data need to be processed, analyzed, and interpreted to address problems in life sciences. Bioinformatics, computational biology, and systems biology deal with biological problems using computational methods. Clustering is one of the methods used to gain insight into biological processes, particularly at the genomics level. Clearly, clustering can be used in many areas of biological data analysis. However, this paper presents a review of the current clustering algorithms designed especially for analyzing gene expression data. It is also intended to introduce one of the main problems in bioinformatics – clustering gene expression data – to the operations research community.     

Impact of computer training courses on reduction of loneliness of older people in Finland and Slovenia

Previous research has shown loneliness as a threat for the quality of life of older people; therefore the goal of the intervention in a quasi-experimental study was to evaluate and discuss the self-reported level of loneliness of older people in Finland and Slovenia before and after a computer intervention. Intervention in a quasi-experimental study was conducted among 58 older participants at the baseline (M = 72.4 years) and 45 older participants at the follow-up research study (M = 72.9 years). Inferential statistics showed a significant difference in the reduction of loneliness between the countries, and a decreased level of loneliness of older people after completing the computer training course. Although older people experience many age-related problems which may reduce their interest in learning information and communication technology (ICT) skills, it is important that they are computer-proficient, because computer engagement can reduce the level of loneliness of older people and in this way has a positive effect on their quality of life.     

Design of a framework for modeling, integration and simulation of physiological models

Multiscale modeling and integration of physiological models carry challenges due to the complex nature of physiological processes. High coupling within and among scales present a significant challenge in constructing and integrating multiscale physiological models. In order to deal with such challenges in a systematic way, there is a significant need for an information technology framework together with related analytical and computational tools that will facilitate integration of models and simulations of complex biological systems. Physiological Model Simulation, Integration and Modeling Framework (Phy-SIM) is an information technology framework providing the tools to facilitate development, integration and simulation of integrated models of human physiology. Phy-SIM brings software level solutions to the challenges raised by the complex nature of physiological systems. The aim of Phy-SIM, and this paper is to lay some foundation with the new approaches such as information flow and modular representation of the physiological models. The ultimate goal is to enhance the development of both the models and the integration approaches of multiscale physiological processes and thus this paper focuses on the design approaches that would achieve such a goal.