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71.
72.
Sing Teang Kong Hai-Shu Lin Jianhong Ching Huiqing Xie Paul C. Ho 《International journal of molecular sciences》2022,23(13)
The immediate and delayed metabolic changes in rats treated with valproate (VPA), a drug used for the treatment of epilepsy, were profiled. An established approach using dried blood spots (DBS) as sample matrices for gas chromatography/mass spectrometry-based metabolomics profiling was modified using double solvents in the extraction of analytes. With the modified method, some of the previously undetectable metabolites were recovered and subtle differences in the metabolic changes upon exposure to a single dose of VPA between males and female rats were identified. In male rats, changes in 2-hydroxybutyric acid, pipecolic acid, tetratriacontane and stearic acid were found between the control and treatment groups at various time points from 2.5 h up to 24 h. In contrast, such differences were not observed in female rats, which could be caused by the vast inter-individual variations in metabolite levels within the female group. Based on the measured DBS drug concentrations, clearance and apparent volume of distribution of VPA were estimated and the values were found to be comparable to those estimated previously from full blood drug concentrations. The current study indicated that DBS is a powerful tool to monitor drug levels and metabolic changes in response to drug treatment. 相似文献
73.
阳离子基团的分布对阴离子交换膜的微观相态和阴离子传导率有显著的影响.为开发全钒液流电池用高性能阴离子交换膜,本文通过向含有二甲胺基团的氟化聚芴醚前驱体接枝含阳离子烷基链的方式,合成了具有相似离子交换容量的一系列侧链多阳离子型氟化聚芴醚.实验结果表明,多阳离子侧链的引入能促进微观相分离的形成并提升阴离子传导率.同时,侧链... 相似文献
74.
Juan Xie Guang-Chao Zheng Yang-Ming Hu Farhat Nosheen Zhi-Cheng Zhang Er-Jun Liang 《稀有金属(英文版)》2021,(1):113-122
Sc-based nanomaterials have attracted consid-erable attention due to their unique optical properties dif-ferent from those of Ln/Y-based nanomaterials.However,s... 相似文献
75.
Yuyu Xie Yunyou Nan Ayub Atif Wencong Hu Yanfeng Zhang Hui Tian Yajun Gao 《International journal of molecular sciences》2022,23(15)
Heterotrimeric guanine nucleotide binding protein (G-protein) consisting of Gα, Gβ, and Gγ subunits is one of the key signal transducers in plants. Recent studies indicated that G-protein has been proposed as an important mediator of nitrogen responses in rice, wheat, and Arabidopsis. However, little is known about these G-proteins in Brassica napus (B. napus), except for three identified G-proteins, BnGA1, BnGB1, and BnGG2. Therefore, the aim of the present study is to characterize the members of the G-protein gene family in allotetraploid B. napus and to analyze their expression profiles in response to nitrogen deprivation. In total, 21 G-protein family members were identified in B. napus, encoding two Gα, six Gβ, and 13 Gγ. Sequence and phylogenetic analyses showed that although genome-wide triploid events increased the number of genes encoding Gα, Gβ, and Gγ subunits, the gene structure and protein properties of the genes encoding each G-protein subunit were extremely conserved. Collinearity analysis showed that most G-protein genes in B. napus had syntenic relationships with G-protein members of Arabidopsis, Brassica rape (B. rapa), and Brassica oleracea (B. oleracea). Expression profile analysis indicated that Gα and C-type Gγ genes (except BnGG10 and BnGG12 were highly expressed in flower and ovule) were barely expressed in most organs, whereas most Gβ and A-type Gγ genes tended to be highly expressed in most organs. G-protein genes also showed various expression patterns in response to nitrogen-deficient conditions. Under nitrogen deficiency, Gα and five C-type Gγ genes were upregulated initially in roots, while in leaves, Gα was downregulated initially and five C-type Gγ genes were highly expressed in different times. These results provide a complex genetic dissection of G-protein genes in B. napus, and insight into the biological functions of G-protein genes in response to nitrogen deficiency. 相似文献
76.
本文针对建立在对等方式下的融合网络提出了一种新的认证和密钥更新算法.认证包括三个方面:非漫游状态下的完整认证、漫游状态下的完整认证以及切换状态下的快速认证.密钥更新包括两个方面:非漫游状态下的密钥更新和漫游状态下的密钥更新.在算法中,通过引入认证中心,不仅实现了网络对用户身份的认证,而且实现了节点对网络身份的认证,由此保证了双方身份的合法性;同时为了实现切换的无缝性,采用节点对认证数据包进行中继转发的方式,减少了切换时的认证时间.性能分析表明,该算法能够有效地抵御常见攻击. 相似文献
77.
Xie Zuoji 《中国有色金属学会会刊》1999,9(3)
1 INTRODUCTIONTheskeletonisaringplatewithmanyholes.Theconventionalqualitycontrolcheckofskeletonismechanicalstrengthandhardnesstesting,itisadestructiveoneandsamplecheckcanonlybeutilized,thus,itsfailureisunavoidable.Ultrasonictestingcannotbeperformedb… 相似文献
78.
With considering the characteristics of keyhole plasma arc welding (K-PAW ),the resonant frequency between arc and molten pool was solved in the frequency range 15000 Hz to 72000 Hz by finite element m... 相似文献
79.
80.
顶层住宅由于其用水、防水、隔热,上下楼不便等缺陷,不受居民的欢迎,在分配及销售上均存在着许多问题。本文对改善顶层住房的舒适性方面,提出了多种综合性措施,将顶层的不利因素转化为有利因素,具有一定的推广价值。 相似文献