Improving fast aspheric convex surface tests with dynamic null screens using LCDs

A method for testing fast aspheric convex surfaces with dynamic null screens using LCDs is shown. A flat null screen is designed and displayed on an LCD monitor with drop-shaped spots in such a way that the image, which is formed by reflection on the test surface, becomes an exactly square array of circular spots if the surface is perfect. Any departure from this geometry is indicative of defects on the surface. Here the whole surface is tested at once. The position of the spots on the LCD can be changed in a dynamic way, to perform point-shifting of the image spots. The proposed procedure improves the dynamic point-shifting method. As has been shown previously, this process reduces the numerical error during the integration procedure, thereby improving the sensitivity of the test. The positioning accuracy for the screen spots is related to the LCD's spatial resolution. Results of the evaluation of a parabolic convex surface with f/#=0.22 are shown.     

Qualitative egomotion

Due to the aperture problem, the only motion measurement in images, whose computation does not require any assumptions about the scene in view, is normal flow—the projection of image motion on the gradient direction. In this paper we show how a monocular observer can estimate its 3D motion relative to the scene by using normal flow measurements in a global and qualitative way. The problem is addressed through a search technique. By checking constraints imposed by 3D motion parameters on the normal flow field, the possible space of solutions is gradually reduced. In the four modules that comprise the solution, constraints of increasing restriction are considered, culminating in testing every single normal flow value for its consistency with a set of motion parameters. The fact that motion is rigid defines geometric relations between certain values of the normal flow field. The selected values form patterns in the image plane that are dependent on only some of the motion parameters. These patterns, which are determined by the signs of the normal flow values, are searched for in order to find the axes of translation and rotation. The third rotational component is computed from normal flow vectors that are only due to rotational motion. Finally, by looking at the complete data set, all solutions that cannot give rise to the given normal flow field are discarded from the solution space.Research supported in part by NSF (Grant IRI-90-57934), ONR (Contract N00014-93-1-0257) and ARPA (Order No. 8459).     

A synbiotic composed of Lactobacillus fermentum CECT5716 and FOS prevents the development of fatty acid liver and glycemic alterations in rats fed a high fructose diet associated with changes in the microbiota

We investigated the effect of a high fructose diet (HFD) on Sprague Dawley rats and the impact of a synbiotic composed of Lactobacillus fermentum CECT5716 and fructooligosaccharides. Feeding the HFD for 5 weeks resulted in liver steatosis and insulin resistance but not obesity. These changes were associated with increased production of short‐chain fatty acids and increased Bacteroidetes in feces, with an augmented Bacteroidetes/Firmicutes ratio, among other changes in the microbiota. In addition, barrier function was weakened, with increased LPS plasma levels. These data are consistent with increased fructose availability in the distal gut due to saturation of absorptive mechanisms, leading to dysbiosis, endotoxemia, hepatic steatosis, and insulin resistance. Treatment with the synbiotic prevented some of the pathological effects, so that treated rats did not develop steatosis or systemic inflammation, while dysbiosis and barrier function were greatly ameliorated. In addition, the synbiotic had hypolipidemic effects. The synbiotic composed by L. fermentum CECT5716 and fructooligosaccharides has beneficial effects in a model of metabolic syndrome induced by a HFD, suggesting it might be clinically useful in this type of condition, particularly considering that high fructose intake has been related to metabolic syndrome in humans.     

Jet Penetration of Surrogate Steel-Explosive Systems

Predicting the jet initiation of an explosive that is covered and in intimate contact with an inert material, is sensitive to the history of the jet in both the cover and the explosive. If the penetration velocity in the cover is subsonic, the acceptor explosive experiences complex wave structures that are significantly different from the case where the penetration velocity is supersonic. The pressure history in the explosive may cause prompt initiation, desensitization, or delayed initiation. We have used transparent polymethylmethacrylate (PMMA) as a surrogate for the explosive, allowing us to experimentally visualize the transition between the subsonic penetration behavior in a steel cover and the quasi-steady supersonic penetration behavior in the PMMA. The wave histories in PMMA downstream from two steel covers of different thicknesses have been measured by streak and image intensifier cameras and by flash radiography simultaneously. These were augmented with pressure gauges to measure the pressure history for one of the thicknesses. These experimental results and subsequent analysis show how initiation of an explosive acceptor can occur at various distances from the interface, depending on the thickness of the cover plate.     

Differential DNA Methylation in Relation to Age and Health Risks of Obesity

The aim of this study was to evaluate whether genome-wide levels of DNA methylation are associated with age and the health risks of obesity (HRO); defined according to BMI categories as “Low HRO” (overweight and class 1 obesity) versus “High HRO” (class 2 and class 3 obesity). Anthropometric measurements were assessed in a subsample of 48 volunteers from the Metabolic Syndrome Reduction in Navarra (RESMENA) study and 24 women from another independent study, Effects of Lipoic Acid and Eicosapentaenoic Acid in Human Obesity (OBEPALIP study). In the pooled population; the methylation levels of 55 CpG sites were significantly associated with age after Benjamini-Hochberg correction. In addition, DNA methylation of three CpG sites located in ELOVL2; HOXC4 and PI4KB were further negatively associated with their mRNA levels. Although no differentially methylated CpG sites were identified in relation to HRO after multiple testing correction; several nominally significant CpG sites were identified in genes related to insulin signaling; energy and lipid metabolism. Moreover, statistically significant associations between BMI or mRNA levels and two HRO-related CpG sites located in GPR133 and ITGB5 are reported. As a conclusion, these findings from two Spanish cohorts add knowledge about the important role of DNA methylation in the age-related regulation of gene expression. In addition; a relevant influence of age on DNA methylation in white blood cells was found, as well as, on a trend level, novel associations between DNA methylation and obesity.     

Prognostic factors and treatment of advanced Hodgkin's disease

Treatment strategy is based on prognosis groups although there is no consensus on their definition. In stages IIIA with unfavorable factors and stages IIIB or IV without high risk factors, chemotherapy alone or followed by irradiation is used. To reduce toxicity, radiation therapy on bulky disease and residual masses is preferred to extended fields. Indications for intensive chemotherapy with autograft of hematopoietic stem cells as initial treatment for high-risk patients must be determined with therapeutic trials.     

Application of a water–energy–food nexus framework for the Duero river basin in Spain

This paper proposes a framework for the identification, assessment and analysis of the water–energy–food nexus at a basin scale. This methodology is applied to the Duero river basin in Spain to detect the most important conflicts derived from water, food and energy interdependencies. Some of the most important issues are the limitations posed by rising energy prices for irrigated agriculture due to modernization, limitations to water treatment, and the possible emergence of new water demands for energy by hydraulic fracturing for oil and gas and enhanced bioenergy.     

Two axiomatic characterizations for the system of spheres-based (and the Epistemic Entrenchment-based) multiple contractions

In some recent works (Reis 2011, Fermé and Reis, J. Philos. Log. 41, 29–52, 2012, Fermé and Reis, Rev. Symb. Log. 6, 460–487, 2013) two new kinds of multiple contraction functions have been proposed, namely the system of spheres-based multiple contractions and the epistemic entrenchment-based multiple contractions, as generalizations (to the case of multiple contraction) of the well-known classes of systems of spheres-based and of epistemic entrenchment-based (singleton) contractions. Additionally, a representation theorem for the class of epistemic entrenchment-based multiple contraction has been proposed, and it has been shown that the two newly proposed constructions are equivalent, in the sense that a multiple contraction function is a system of spheres-based multiple contraction if and only if it is an epistemic entrenchment-based multiple contraction. In this paper we present two axiomatic characterizations for those multiple contraction functions which differ from the one mentioned above and, in particular, make use of some more intuitive postulates.