The effects of distributional learning on rats' sensitivity to phonetic information.

During the first year of life, infants show decreased sensitivity to phonetic differences not used in their native language and increased sensitivity to the differences that are used. It has been shown that this change in speech perception is a function of the distributional properties of the input. The present study explores whether the mechanism responsible for the developmental changes regarding the organization of phonetic categories is a general mechanism shared with other animals. The results demonstrate that the distributional exposure to a phonetic continuum affects the subsequent discrimination of these phonemes in rats, indicating that the ability to use distributional cues to change the phonetic category structure extends beyond humans. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

High-Speed High-Precision CMOS Current Conveyor

In this paper a new class-AB CMOS second generation current conveyor (CCII) based on a novel high-performance voltage follower topology is proposed. Post-layout simulation results from a 0.8 m design supplied at 3.3 V show very low resistance at node X (<50 ), high frequency operation (100 MHz), high precision in the voltage and current transference and reduced offset. As application examples, a V-I converter and a current feedback operational amplifier (CFOA) have been implemented. The latter presents slew-rate levels higher than ±100 V/s.     

Continuous-Time 4th Order Butterworth Low-Pass Filter for Video Frequency Applications

In this paper, a continuous-time 4th order Butterworth low-pass filter based on current-mode processing is presented for applications over the video frequency range. A new type of integrator in which both voltage and currents may be integrated is presented and used as the main active block. The filter has been implemented using a very low-cost 2.4 m CMOS process (Mietec). The whole circuit occupies 2.8 mm² and consumes 19 mW from a ±1.5 V supply. Experimental results are given for a 4.5 MHz to 12 MHz tunable low-pass filter with 58 dB of dynamic range at 10 MHz.     

Interplay between Humoral and CLA+ T Cell Response against Candida albicans in Psoriasis

Candida albicans (CA) infections have been associated with psoriasis onset or disease flares. However, the integrated immune response against this fungus is still poorly characterized in psoriasis. We studied specific immunoglobulins in plasma and the CA response in cocultures of circulating memory CD45RA⁻ cutaneous lymphocyte antigen (CLA)^+/− T cell with autologous epidermal cells from plaque and guttate psoriasis patients (cohort 1, n = 52), and also healthy individuals (n = 17). A complete proteomic profile was also evaluated in plaque psoriasis patients (cohort 2, n = 114) regarding their anti-CA IgA levels. Increased anti-CA IgA and IgG levels are present in the plasma from plaque but not guttate psoriasis compared to healthy controls. CA cellular response is confined to CLA⁺ T cells and is primarily Th17. The levels of anti-CA IgA are directly associated with CLA⁺ Th17 response in plaque psoriasis. Proteomic analysis revealed distinct profiles in psoriasis patients with high anti-CA IgA. C-C motif chemokine ligand 18, chitinase-3-like protein 1 and azurocidin were significantly elevated in the plasma from plaque psoriasis patients with high anti-CA levels and severe disease. Our results indicate a mechanism by which Candida albicans exposure can trigger a clinically relevant IL-17 response in psoriasis. Assessing anti-CA IgA levels may be useful in order to evaluate chronic psoriasis patients.     

A survey on geometrical reconstruction as a core technology to sketch-based modeling

In this work, the background and evolution of three-dimensional reconstruction of line drawings during the last 30 years is discussed. A new general taxonomy is proposed to make apparent and discuss the historical evolution of geometrical reconstruction and their challenges. The evolution of geometrical reconstruction from recovering know-how stored in engineering drawings to sketch-based modeling for helping in the first steps of conceptual design purposes, and the current challenges of geometrical reconstruction are discussed too.     

The Peculiar Structure of Acetobacter pasteurianus CIP103108 LPS Core Oligosaccharide

Acetobacter pasteurianus, a member of the Alphaproteobacteria, is an acetic acid-producing bacterium present on sugar-rich substrates such as such as fruits, flowers and vegetables and traditionally used in the production of fermented food. The preferred living habitat associated with acid conditions makes the structure of the bacterial cell wall interesting to study, due to expected uncommon features. We have used a combination of chemical, analytical and NMR spectroscopy approaches to define the complete structure of the core oligosaccharide from A. pasteurianus CIP103108 LPS. Interestingly, the core oligosaccharide displays a high concentration of negatively charged groups, structural features that might contribute to reinforcing the bacterial membrane.     

A good practice for making training accessible to university faculty members through ICTs: syllabus planning support training

Universal Access in the Information Society - This study focuses on a case study developed at a higher education institution, which comprises developing a new virtual teaching unit (VTU) aimed at...     

Rare Titin (TTN) Variants in Diseases Associated with Sudden Cardiac Death

A leading cause of death in western countries is sudden cardiac death, and can be associated with genetic disease. Next-generation sequencing has allowed thorough analysis of genes associated with this entity, including, most recently, titin. We aimed to identify potentially pathogenic genetic variants in titin. A total of 1126 samples were analyzed using a custom sequencing panel including major genes related to sudden cardiac death. Our cohort was divided into three groups: 432 cases from patients with cardiomyopathies, 130 cases from patients with channelopathies, and 564 post-mortem samples from individuals showing anatomical healthy hearts and non-conclusive causes of death after comprehensive autopsy. None of the patients included had definite pathogenic variants in the genes analyzed by our custom cardio-panel. Retrospective analysis comparing the in-house database and available public databases also was performed. We identified 554 rare variants in titin, 282 of which were novel. Seven were previously reported as pathogenic. Of these 554 variants, 493 were missense variants, 233 of which were novel. Of all variants identified, 399 were unique and 155 were identified at least twice. No definite pathogenic variants were identified in any of genes analyzed. We identified rare, mostly novel, titin variants that seem to play a potentially pathogenic role in sudden cardiac death. Additional studies should be performed to clarify the role of these variants in sudden cardiac death.     

Concentrations and determinants of organochlorine levels among pregnant women in Eastern Spain

Persistent organic pollutants (POPs) comprise a large variety of toxic substances with ample distribution. While exposure to these toxins occurs mainly through diet, maternal POP levels may be influenced by certain sociodemographic, environmental, or lifestyle factors. This is important given that these substances may have adverse effects on fetal development. The aim of this study is to examine the sociodemographic, environmental, lifestyle, and dietary determinants of the levels of hexachlorobenzene (HCB), b-hexachlorocyclohexane (b-HCH), 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane (4,4′-DDT), 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene (4,4′-DDE), and polychlorinated biphenyls (PCB congeners 118, 138, 153, 180) measured in the blood of pregnant women participating in a mother-child cohort study conducted in Valencia (Spain).The study population consisted of 541 pregnant women who formed part of the INMA (Childhood and the Environment) cohort (2004-2006). POP levels were determined in blood taken during the 12th week of pregnancy with the aid of gas chromatography with electron capture detection. Sociodemographic, environmental, and dietary information was obtained from a questionnaire. Multivariate Tobit regression models were constructed in order to assess the association between POP levels and selected covariates.The results showed that all the women had detectable levels of at least one of these compounds while in 43% of the subjects, all eight compounds were detected. The compounds found in the greatest number of women were 4,4′-DDE (100%) and PCBs 153 and 180 (95%). The most important determinants of high POP levels were the mother's age, country of origin, increased body mass index, and number of weeks of breastfeeding after previous pregnancies. With regard to diet, 4,4′-DDT and 4,4′-DDE levels increased with the intake of meat, fruit, and cereal. PCB 153 levels increased with the intake of seafood. The levels of HCB, b-HCH, 4,4′-DDT, and 4,4′-DDE observed in this study were slightly higher than in other studies, whereas the PCB levels were similar.