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71.
72.
Roberta Papagni Carmen Pellegrino Francesco Di Gennaro Giulia Patti Aurelia Ricciardi Roberta Novara Sergio Cotugno Maria Musso Giacomo Guido Luigi Ronga Stefania Stolfa Davide Fiore Bavaro Federica Romanelli Valentina Totaro Rossana Lattanzio Giuseppina De Iaco Fabrizio Palmieri Annalisa Saracino Gina Gualano 《International journal of molecular sciences》2022,23(7)
Vitamin D plays a crucial role in many infectious diseases, such as tuberculosis (TB), that remains one of the world’s top infectious killers with 1.5 million deaths from TB in 2021. Vitamin D suppresses the replication of Mycobacterium tuberculosis in vitro and showed a promising role in TB management as a result of its connection with oxidative balance. Our review encourages the possible in vivo benefit of a joint administration with other vitamins, such as vitamin A, which share a known antimycobacterial action with vitamin D. However, considering the low incidence of side effects even at high dosages and its low cost, it would be advisable to assess vitamin D level both in patients with active TB and high-risk groups and administer it, at least to reach sufficiency levels. 相似文献
73.
Alessandra Scagliola Annarita Miluzio Giada Mori Sara Ricciardi Stefania Oliveto Nicola Manfrini Stefano Biffo 《International journal of molecular sciences》2022,23(14)
Nonalcoholic fatty liver disease (NAFLD) is characterized by the accumulation of lipids in the liver. Given the high prevalence of NAFLD, its evolution to nonalcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC) is of global concern. Therapies for managing NASH-driven HCC can benefit from targeting factors that play a continuous role in NAFLD evolution to HCC. Recent work has shown that postprandial liver translation exacerbates lipid accumulation through the activity of a translation factor, eukaryotic initiation factor 6 (eIF6). Here, we test the effect of eIF6 inhibition on the progression of HCC. Mice heterozygous for eIF6 express half the level of eIF6 compared to wt mice and are resistant to the formation of HCC nodules upon exposure to a high fat/high sugar diet combined with liver damage. Histology showed that nodules in eIF6 het mice were smaller with reduced proliferation compared to wt nodules. By using an in vitro model of human HCC, we confirm that eIF6 depletion reduces the growth of HCC spheroids. We also tested three pharmacological inhibitors of eIF6 activity—eIFsixty-1, eIFsixty-4, and eIFsixty-6—and all three reduced eIF6 binding to 60S ribosomes and limited the growth of HCC spheroids. Thus, inhibition of eIF6 activity is feasible and limits HCC formation. 相似文献
74.
This work analyses the links between individual research performance and academic rank. A typical bibliometric methodology
is used to study the performance of all Italian university researchers active in the hard sciences, for the period 2004–2008.
The objective is to characterize the performance of the ranks of full (FPs), associate and assistant professors (APs), along
various dimensions, in order to verify the existence of performance differences among the ranks in general and for single
disciplines. 相似文献
75.
Terranova Maria Livia; Loggi Giampietro; Chiarotti Flavia; Laviola Giovanni 《Canadian Metallurgical Quarterly》2000,114(4):325
Mice (Mus musculus domesticus) were raised (Postnatal Day 15 to 25) in single- or mixed-sex litters and precociously (Day 15) or regularly (Day 25) weaned. When they were faced as adults with a basic social choice—between two stimulus mice raised in litters of different sex composition but both of the same sex as the chooser—mice raised in mixed-sex litters were preferred. In the sociosexual choice—between a male and a female, both from the single- or the mixed-sex group—the opposite-sex preference was expressed. Both these preferences were abolished by the sexual segregation of the choosers. This variable hardly affected potential mate choice—between two stimulus mice both of the opposite sex of the chooser but raised in litters of different sex composition. Data indicate that socially mediated behavioral plasticity has a major role in the early shaping of adult individual differences both in attractive stimulus properties and in sociosexual preferences. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
76.
Ruth Flavia Vera Villamil Jaimes Mónica Luisa Chaves de Andrade Afonso Silvia Maria Leite Agostinho 《Materials Letters》2010,64(13):1476-1479
Nickel, a component of stainless steels (SS) applied in orthopedic implants may cause allergic processes in human tissues. P558 nickel free SS was studied to verify its viability as a substitute for stainless steel containing nickel. Its performance is compared to ISO 5832-9 and F138 most used nowadays grades in implants fabrications, in minimum essential medium, MEM, at 37 °C. Potentiodynamic polarization curves, electrochemical impedance spectroscopy (EIS), scanning electron microscopy (SEM) and “in vitro” cytotoxicity were used as techniques. From the electrochemical point of view P558 SS is comparable to ISO 5832-9 SS in MEM. It remains passivated until the transpassivation potential, above which generalized corrosion occurs. F138 presents pitting corrosion at 370 mV/SCE. The cytotoxicity results showed that P558, ISO 5832-9 and F138 do not present cytotoxic character. Therefore, these results suggest that P558 SS can be applied in orthopedic implants. 相似文献
77.
Esteves Eduardo Kadyampakeni Davie M. Zambon Flavia Ferrarezi Rhuanito S. Maltais-Landry Gabriel 《Nutrient Cycling in Agroecosystems》2022,122(1):73-87
Nutrient Cycling in Agroecosystems - Citrus production has been declining in Florida since 2004, mainly because of Huanglongbing (HLB), a deadly disease that is affecting an increasingly large... 相似文献
78.
Films made from polyethylene‐co‐acrylic acid and soluble biopolymers sourced from agricultural and municipal biowaste 下载免费PDF全文
Flavia Franzoso Damiano Causone Silvia Tabasso Diego Antonioli Enzo Montoneri Paola Persico Michele Laus Raniero Mendichi Michele Negre 《应用聚合物科学杂志》2015,132(18)
Blends were obtained from polyethylene‐co‐acrylic acid (PEAA) with 248 kDa molecular weight and two water soluble biopolymers isolated from the hydrolysate of postharvest tomato plant and urban biowaste compost. The two hydrolysates were constituted respectively from a polysaccharide (SP) with 27 kDa molecular weight and a lignin‐like polymer (LP) with 75 kDa molecular weight containing aliphatic and aromatic C moieties substituted by carboxyl, hydroxyl, and amino groups. Evidence was obtained for reactions occurring between the biopolymers and the synthetic polymer leading to new polymers with 151 to 1243 kDa molecular weights. The thermal and mechanical properties of the blends were studied. Compared with neat PEAA, the PEAA‐LP blends containing 5 to 10% LP exhibited 2 to 5× higher molecular weights, 10 to 50% lower crystallinity, 2 to 6× higher Young's modulus, over 3× higher stress at yield point and somewhat lower strain at break (55–280% vs. over 300%). On the contrary the PEAA‐SP blends exhibited 6 to 13% lower crystallinity and the same mechanical properties as neat PEAA. The results offer scope for investigating biopolymers sourced from other biowastes to understand more the reasons of the observed effects and exploit their full potential to modify or to replace synthetic polymers. Perspectives of economic and environmental benefits are discussed. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132, 41909. 相似文献
79.
80.
Gutiérrez Lezama I Nakano M Minder NA Chen Z Di Girolamo FV Facchetti A Morpurgo AF 《Nature materials》2012,11(9):788-794
Organic semiconductors based on small conjugated molecules generally behave as insulators when undoped, but the heterointerfaces of two such materials can show electrical conductivity as large as in a metal. Although charge transfer is commonly invoked to explain the phenomenon, the details of the process and the nature of the interfacial charge carriers remain largely unexplored. Here we use Schottky-gated heterostructures to probe the conducting layer at the interface between rubrene and PDIF-CN(2) single crystals. Gate-modulated conductivity measurements demonstrate that interfacial transport is due to electrons, whose mobility exhibits band-like behaviour from room temperature to ~150 K, and remains as high as ~1 cm(2) V(-1) s(-1) at 30 K for the best devices. The electron density decreases linearly with decreasing temperature, an observation that can be explained quantitatively on the basis of the heterostructure band diagram. These results elucidate the electronic structure of rubrene/PDIF-CN(2) interfaces and show the potential of Schottky-gated organic heterostructures for the investigation of transport in molecular semiconductors. 相似文献