A fully digital, energy-efficient, adaptive power-supply regulator

A voltage scaling technique for energy-efficient operation requires an adaptive power-supply regulator to significantly reduce dynamic power consumption in synchronous digital circuits. A digitally controlled power converter that dynamically tracks circuit performance with a ring oscillator and regulates the supply voltage to the minimum required to operate at a desired frequency is presented. This paper investigates the issues involved in designing a fully digital power converter and describes a design fabricated in a MOSIS 0.8-μm process. A variable-frequency digital controller design takes advantage of the power savings available through adaptive supply-voltage scaling and demonstrates converter efficiency greater than 90% over a dynamic range of regulated voltage levels     

Improving Head Movement Tolerance of Cross-Ratio Based Eye Trackers

When first introduced, the cross-ratio (CR) based remote eye tracking method offered many attractive features for natural human gaze-based interaction, such as simple camera setup, no user calibration, and invariance to head motion. However, due to many simplification assumptions, current CR-based methods are still sensitive to head movements. In this paper, we revisit the CR-based method and introduce two new extensions to improve the robustness of the method to head motion. The first method dynamically compensates for scale changes in the corneal reflection pattern, and the second method estimates true coplanar eye features so that the cross-ratio can be applied. We present real-time implementations of both systems, and compare the performance of these new methods using simulations and user experiments. Our results show a significant improvement in robustness to head motion and, for the user experiments in particular, an average reduction of up to 40 % in gaze estimation error was observed.     

First plasma operation of the enhanced JET vertical stabilisation system

A project dedicated to the enhancement of the JET vertical stabilization system was launched in 2006, including an upgrade of the Power Supply of the Radial Field Amplifier, of hardware and software of the vertical stabilization control system. The main aim was to double the JET capability in stabilising high current plasmas when subject to perturbations, in particular large Edge Localised Modes. We present here the results of first plasma operation with the new Enhanced Radial Field Amplifier and its data acquisition and control system, focussing on the benefits of an approach based on phased commissioning, modelling and offline algorithm validation.     

Synthesis and Structure−Activity Relationships of Imidazopyridine/Pyrimidine- and Furopyridine-Based Anti-infective Agents against Trypanosomiases

Neglected tropical diseases remain among the most critical public health concerns in Africa and South America. The drug treatments for these diseases are limited, which invariably leads to fatal cases. Hence, there is an urgent need for new antitrypanosomal drugs. To address this issue, a large number of diverse heterocyclic compounds were prepared. Straightforward synthetic approaches tolerated pre-functionalized structures, giving rise to a structurally diverse set of analogs. We report on a set of 57 heterocyclic compounds with selective activity potential against kinetoplastid parasites. In general, 29 and 19 compounds of the total set could be defined as active against Trypanosoma cruzi and T. brucei brucei, respectively (antitrypanosomal activities <10 μM). The present work discusses the structure−activity relationships of new fused-ring scaffolds based on imidazopyridine/pyrimidine and furopyridine cores. This library of compounds shows significant potential for anti-trypanosomiases drug discovery.     

Correlation between microstructure and corrosion behavior in an AISI 316L steel pipeline exposed for 100,700 h at 640°C in a petrochemical plant

The microstructure and electrochemical properties of 316L stainless steel were investigated after two conditions: aged at 640°C for 100,700 h and solution annealed at 1050°C for 2 h. While the aged samples were obtained from a pipe of a petrochemical reactor plant that was in service, the solution annealing was carried out in a conventional laboratory furnace. After aging, the precipitates present in decreasing order of quantity were sigma, Laves phase, and M₂₃C₆. After solution annealing, the microstructure was full austenitic. These results were in agreement with equilibria phase simulation with Thermo-Calc software. Intergranular corrosion susceptibility, evaluated by means of the single loop electrochemical potentiokinetic reactivation technique and Practice A of ASTM 262, indicated a preponderant role for the sigma precipitate. The pitting potential (E_pit) was evaluated through potentiodynamic polarization curves in 0.6 M NaCl and electrochemical impedance spectroscopy was performed at the corrosion potential to complement the information about the corrosion resistance.     

Preliminary Mechanical Characterization of Thermal Filters for the X-IFU Instrument on Athena

The X-ray Integral Field Unit (X-IFU) is one of the two instruments of the Athena astrophysics space mission approved by ESA in the Cosmic Vision Science Program. The X-IFU consists of a large array of TES microcalorimeters that will operate at?~?50 mK inside a sophisticated cryostat. A set of thin filters, highly transparent to X-rays, will be mounted on the cryostat thermal shields in order to attenuate the IR radiative load, to attenuate RF electromagnetic interferences, and to protect the detector from contamination. In this paper, we present the current thermal filters design, describe the filter samples developed/procured so far, and present preliminary results from the ongoing characterization tests.     

Registration and interactive planar segmentation for stereo images of polyhedral scenes

We introduce a two-step iterative segmentation and registration method to find coplanar surfaces among stereo images of a polyhedral environment. The novelties of this paper are: (i) to propose a user-defined initialization easing the image matching and segmentation, (ii) to incorporate color appearance and planar projection information into a Bayesian segmentation scheme, and (iii) to add consistency to the projective transformations related to the polyhedral structure of the scenes. The method utilizes an assisted Bayesian color segmentation scheme. The initial user-assisted segmentation is used to define search regions for planar homography image registration. The two reliable methods cooperate to obtain probabilities for coplanar regions with similar color information that are used to get a new segmentation by means of quadratic Markov measure fields (QMMF). We search for the best regions by iterating both steps: registration and segmentation.     

Cervical cancer survival in a high risk urban population

BACKGROUND: Cervical cancer remains an important public health problem, particularly for the urban minority population. To the authors' knowledge, determinants of cervical cancer survival have not been studied in this high risk population. METHODS: This study included all 158 women diagnosed and treated for invasive cervical cancer from January 1, 1986, through December 31, 1992, at the Grady Memorial Hospital and Clinics (Atlanta, GA). Medical records were abstracted to determine age at diagnosis, race, International Federation of Gynecology and Obstetrics (FIGO) clinical stage, treatment, and survival. Pathologic material was reviewed to confirm the diagnosis. RESULTS: Most patients (80%) were African American, and the stage distribution was similar for African American and white patients. Sixty-six (42%) had FIGO Stage I disease; 50%, Stage II or III; and 8%, Stage IV. Four-year actuarial survival differed significantly according to clinical stage (Ia = 94%, Ib = 79%, II = 39%, III = 26%, IV = 0%). Overall survival was lower for patients with glandular carcinomas than for those with squamous cell carcinomas (26% vs. 55%, P = 0.09). This difference was almost entirely due to increased mortality in patients with Stage Ib adenocarcinomas (53% vs. 88% for squamous cell carcinoma, Stage Ib, P = 0.03). CONCLUSIONS: The major prognostic markers for cervical cancer survival in this high risk patient population were clinical stage and histology, factors identical to those identified for other populations.