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101.
Richard D Ling B Authier N Faict TW Eschalier A Coudoré F 《Analytical chemistry》2005,77(5):1354-1360
To quantify gamma-hydroxybutyrate (GHB) and its physiological metabolites, gamma-aminobutyric acid (GABA), 1,4-butanediol (1,4-BD), and gamma-butyrolactone (GBL) in various animal tissues (kidney, muscle, heart, liver, blood, brain cortex, thalamus, hypothalamus, hippocampus, or pons), an original gas chromatographic/mass spectrometric method with a automated solid-phase extraction by Oasis MCX cartridges on a Gilson Aspec Xli was developed. Using such apparatus allowed the limit of detection (LOD) of target compounds to be significantly lowered (LOD: 0.027, 0.025, and 5.7 microg/mL for GHB, 1,4-BD, and GABA, respectively, in 200 microL or microg of sample). After validation of each analytical step, the satisfactory performances of the apparatus in conjunction with the rapidity and ease of the extraction step make it suitable for simultaneous assay of GHB, 1,4-BD, GBL, and GABA. The method was used to test the correlation between GHB levels in tissues obtained at different times after death of male Sprague-Dawley rats and the postmortem interval. Preliminary results show a linear increase of GHB levels in relation to time of death in thoracic blood and central nervous system of animals kept at 15 and 20 degrees C. 相似文献
102.
S. François M. Schevenels G. Lombaert G. Degrande 《International journal for numerical methods in engineering》2012,90(7):819-837
This paper presents a perfectly matched layer (PML) technique for the numerical simulation of three‐dimensional linear elastodynamic problems, where the geometry is invariant in the longitudinal direction. Examples include transportation infrastructure, dams, lifelines, and alluvial valleys. For longitudinally invariant geometries, a computationally efficient two‐and‐a‐half‐dimensional (2.5D) approach can be applied, where the Fourier transform from the longitudinal coordinate to the wavenumber domain allows for the representation of the three‐dimensional radiated wave field on a two‐dimensional mesh. In this 2.5D framework, the equilibrium equations of a PML continuum are formulated in a weak form for an isotropic elastodynamic medium and discretized using a Galerkin approach. The 2.5D PML methodology is validated by computing the Green's displacements of a homogeneous halfspace, demonstrating that the 2.5D PML absorbs all propagating waves for different angles of incidence. Furthermore, the dynamic stiffness of a rigid strip foundation and the efficiency of a vibration isolating screen are computed. The examples demonstrate that the PML methodology is computationally efficient, especially when only the response of the structure or the near field response is of interest.Copyright © 2011 John Wiley & Sons, Ltd. 相似文献
103.
AG Garcia M Neumann F Amet JR Williams K Watanabe T Taniguchi D Goldhaber-Gordon 《Nano letters》2012,12(9):4449-4454
Hexagonal boron nitride (h-BN) films have attracted considerable interest as substrates for graphene. ( Dean, C. R. et al. Nat. Nanotechnol. 2010 , 5 , 722 - 6 ; Wang, H. et al. Electron Device Lett. 2011 , 32 , 1209 - 1211 ; Sanchez-Yamagishi, J. et al. Phys. Rev. Lett. 2012 , 108 , 1 - 5 .) We study the presence of organic contaminants introduced by standard lithography and substrate transfer processing on h-BN films exfoliated on silicon oxide substrates. Exposure to photoresist processing adds a large broad luminescence peak to the Raman spectrum of the h-BN flake. This signal persists through typical furnace annealing recipes (Ar/H(2)). A recipe that successfully removes organic contaminants and results in clean h-BN flakes involves treatment in Ar/O(2) at 500 °C. 相似文献
104.
105.
Sahli L Afri-Mehennaoui FZ El Hadef El Okki M Férard JF Mehennaoui S 《Water science and technology》2012,65(2):393-401
The objectives of this study are to use different approaches to assess the current pollution status in the wadis of the Kebir Rhumel basin. First, sediment trace metal contents were measured by flame atomic absorption spectroscopy. Then, sediment quality was assessed on the basis of contamination assessment indexes such as: Geoaccumulation Index (Igeo), Contamination factor (C(f)), Contamination degree (C(d)), Sediment Pollution Index (SPI) and SEQ guidelines (Consensus Sediment Quality Guidelines). In addition, several toxicity tests (Daphnia magna mobility inhibition acute test-48 h, Aliivibrio fischeri luminescence inhibition acute test - 15/30 mn and Pseudokirchneriella subcapitata growth inhibition chronic test - 72 h) were conducted to assess sediment pore water ecotoxicity. Trace metal concentrations followed the order: Mn > Zn > Pb > Cr > Cu > Ni > Co > Cd. Indexes used indicate varying degrees of sediment quality. Igeo, C(f), C(d) and SPI reveal a polymetallic contamination dominated by two or more elements in which Cd, Cu and Pb are of greatest concern. SEQ guidelines showed that biological effects on fauna would likely be observed occasionally and/or frequently for Cd, Cr, Cu, Pb and Zn contents. Test organisms exposed to sediment pore water showed that the algal P. subcapitata test was more sensitive than the D. magna and A. fischeri tests. Hence, algal growth inhibition proved to be the most sensitive response to contaminants present in sediment extracts but a significant relationship with trace metal contents was not demonstrated. 相似文献
106.
Aicha Loucif Roberto B. Figueiredo Megumi Kawasaki Thierry Baudin Fran?ois Brisset Rafik Chemam Terence G. Langdon 《Journal of Materials Science》2012,47(22):7815-7820
Experiments were conducted to evaluate the microstructural evolution in a commercial Al-0.6 % Mg-0.4 % Si alloy processed using high-pressure torsion for up to 20 turns. Disks of the alloy were tested in two different conditions: in a solution-treated condition and after a short aging treatment at 523 K. The results show that HPT processing introduces significant grain refinement through HPT processing including a reduction in grain size from ~150 μm to ~720 nm in 1 turn of HPT. The final grain size in this alloy was ~250 nm after 20 turns. Some tensile tests were conducted to evaluate the mechanical properties of the alloy at the solution treatment temperature. The results from these tests show that aging at 523 K leads to a small increase in ductility for all tensile samples with a maximum recorded elongation of ~230 %. 相似文献
107.
Ivan Rehor Jitka Slegerova Jan Kucka Vladimir Proks Vladimira Petrakova Marie‐Pierre Adam François Treussart Stuart Turner Sara Bals Pavel Sacha Miroslav Ledvina Amy M. Wen Nicole F. Steinmetz Petr Cigler 《Small (Weinheim an der Bergstrasse, Germany)》2014,10(6):1106-1115
High pressure high temperature (HPHT) nanodiamonds (NDs) represent extremely promising materials for construction of fluorescent nanoprobes and nanosensors. However, some properties of bare NDs limit their direct use in these applications: they precipitate in biological solutions, only a limited set of bio‐orthogonal conjugation techniques is available and the accessible material is greatly polydisperse in shape. In this work, we encapsulate bright 30‐nm fluorescent nanodiamonds (FNDs) in 10–20‐nm thick translucent (i.e., not altering FND fluorescence) silica shells, yielding monodisperse near‐spherical particles of mean diameter 66 nm. High yield modification of the shells with PEG chains stabilizes the particles in ionic solutions, making them applicable in biological environments. We further modify the opposite ends of PEG chains with fluorescent dyes or vectoring peptide using click chemistry. High conversion of this bio‐orthogonal coupling yielded circa 2000 dye or peptide molecules on a single FND. We demonstrate the superior properties of these particles by in vitro interaction with human prostate cancer cells: while bare nanodiamonds strongly aggregate in the buffer and adsorb onto the cell membrane, the shell encapsulated NDs do not adsorb nonspecifically and they penetrate inside the cells. 相似文献
108.
A modern fringe-pattern-analyzing interferometer with a resolution of 1 x 10(-9) and without exclusion of systematic uncertainties owing to optic effects of less than 1 nm was used to test a new method of interferometric length measurement based on a combination of the reproducible wringing and slave-block techniques. Measurements without excessive wringing film error are demonstrated for blocks with nominal lengths of 2-6 mm and with high surface flatness. The uncertainty achieved for these blocks is less than 1 nm. Deformations of steel gauge blocks and reference platens, caused by wringing forces, are investigated, and the necessary conditions for reproducible wringing are outlined. A subnanometer uncertainty level in phase-change-correction measurements has been achieved for gauge blocks as long as 100 mm. Limitations on the accuracy standard method of interferometric length measurements and shortcomings of the present definition of the length of the material artifact are emphasized. 相似文献
109.
Nebulized Gadolinium‐Based Nanoparticles: A Theranostic Approach for Lung Tumor Imaging and Radiosensitization 下载免费PDF全文
Sandrine Dufort Andrea Bianchi Maxime Henry François Lux Géraldine Le Duc Véronique Josserand Cédric Louis Pascal Perriat Yannick Crémillieux Olivier Tillement Jean‐Luc Coll 《Small (Weinheim an der Bergstrasse, Germany)》2015,11(2):215-221
Lung cancer is the most common and most fatal cancer worldwide. Thus, improving early diagnosis and therapy is necessary. Previously, gadolinium‐based ultra‐small rigid platforms (USRPs) were developed to serve as multimodal imaging probes and as radiosensitizing agents. In addition, it was demonstrated that USRPs can be detected in the lungs using ultrashort echo‐time magnetic resonance imaging (UTE‐MRI) and fluorescence imaging after intrapulmonary administration in healthy animals. The goal of the present study is to evaluate their theranostic properties in mice with bioluminescent orthotopic lung cancer, after intrapulmonary nebulization or conventional intravenous administration. It is found that lung tumors can be detected non‐invasively using fluorescence tomography or UTE‐MRI after nebulization of USRPs, and this is confirmed by histological analysis of the lung sections. The deposition of USRPs around the tumor nodules is sufficient to generate a radiosensitizing effect when the mice are subjected to a single dose of 10 Gy conventional radiation one day after inhalation (mean survival time of 112 days versus 77 days for irradiated mice without USRPs treatment). No apparent systemic toxicity or induction of inflammation is observed. These results demonstrate the theranostic properties of USRPs for the multimodal detection of lung tumors and improved radiotherapy after nebulization. 相似文献
110.
In this study, different tap water handling strategies were investigated to evaluate the effects on two principal chlorinated DBPs, trihalomethanes (THMs) and haloacetic acids (HAAs). Tap water samples collected in the Quebec City (Canada) distribution system on a spatio-temporal basis were subjected to diverse indoor handling scenarios: storing water in the refrigerator, boiling water followed by storage and, finally, filtering water with a point-of-use commercial pitcher also followed by storage. In the first two cases, the use of covered and uncovered pitchers was investigated separately, while in the last case, both the use of new and used filters was compared. In all cases, maximum storage time was 48h. Results demonstrated that in some cases, water handling scenarios have considerable effect, and in other cases, little or no effect. Removal of THM concentrations by simple storage was high (on average 30%) and very high by boiling and filtering with subsequent storage in the refrigerator (on average, 87% and 92%, respectively). In scenarios where water was stored in uncovered pitchers (with or without previous boiling and filtering), the THM decrease was higher for increased storage times. However, storage did not have any effect on HAAs, whereas boiling decreased levels of trichloroacetic acid (TCAA) (on average 42%) and increased levels of dichloroacetic acid (DCAA) (on average 35%), resulting in unchanged average levels of total HAAs. The use of the filtration pitcher decreased HAA levels dramatically (on average 66%). Percentages of change in chlorinated DBPs in the different scenarios varied according to initial concentrations in tap water (baseline water), that is, according to the spatio-temporal variations of these substances in the distribution system. On the basis of these results, the paper discusses implications regarding public health protection and exposure assessment for epidemiological studies. 相似文献