Long-Term Measures of Dyslipidemia,Inflammation, and Oxidative Stress in Rats Fed a High-Fat/High-Fructose Diet

Inflammation and oxidative stress are thought to be involved in, or associated with, the development of obesity, dyslipidemia, hepatic steatosis, and insulin resistance. This work was designed to determine the evolution of inflammation and oxidative stress during onset and progression of hepatic steatosis and glucose intolerance. Seventy-five male Wistar rats were divided to control and high-fat high-fructose (HFHFr) groups. A subgroup of each group was sacrificed at 4, 8, 12, 16, and 20 weeks. HFHFr-fed rats exhibited overweight, glucose intolerance, and hepatic steatosis with increased contents of hepatic diacylglycerols and ceramides. The HFHFr diet increased hepatic interleukin 6 (IL-6) protein and adipose tissue CCL5 gene expression and hepatic nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity but not mitochondrial reactive oxygen species (ROS) production. The HFHFr diet decreased plasma and liver levels of isoprostanoid metabolites as well as plasma thiobarbituric acid-reactive substance (TBARS) levels. Hepatic glutathione content was decreased with a moderate decrease in superoxide dismutase (SOD) and glutathione peroxidase (GPx) with the HFHFr diet. Overall, HFHFr diet led to hepatic lipid accumulation and glucose intolerance, which were accompanied by only moderate inflammation and oxidative stress. Most of these changes occurred at the same time and as early as 8 or 12 weeks of diet treatment. This implies that oxidative stress may be the result, not the cause, of these metabolic alterations, and suggests that marked hepatic oxidative stress should probably occur at the end of the steatotic stage to result in frank insulin resistance and steatohepatitis. These findings need to be further evaluated in other animal species as well as in human studies.     

Performance of Sulfate-reducing Passive Bioreactors for the Removal of Cd and Zn from Mine Drainage in a Cold Climate

Mine Water and the Environment - Passive treatment is a promising, green technology that is increasingly being used for mine drainage treatment. However, several challenges remain concerning its...     

独眼巨人住宅群:第潘达的12间隔音房

这十二座房屋位于希尔维苏姆市(Hilversum)森林内的一个高级住宅区--第潘达(Diependaal),沿着该地区的一条二级公路,形成了隔音防线的主体.尽管它们所处的位置十分荒凉,客户最初对此也怀有疑虑,但其充满未来主义色彩的设计思路还是吸引了顾客,使他们甘心购买当时还仅存在于图纸上、数年后才能交付使用的房屋.     

Comparison of autologous bone marrow transplantation and intensive chemotherapy as postremission therapy in adult acute myeloid leukemia. The Groupe Ouest Est Leucémies Aigu?s Myéloblastiques (GOELAM)

Three intensive consolidation strategies are currently proposed to younger adults with acute myeloid leukemia (AML) in first complete remission (CR): allogeneic or autologous bone marrow transplantation (BMT) and intensive consolidation chemotherapy (ICC). Patients aged 15 to 50 years with de novo AML received an induction treatment with 7 days of cytarabine and either idarubicin or rubidazone. After achievement of a CR, patients up to the age of 40 and having an HLA-identical sibling were assigned to undergo an allogeneic BMT. All the other patients received a first course of ICC with high-dose cytarabine and the same anthracycline as for induction. They were then randomly assigned to either receive a second course of ICC with amsacrine and etoposide or a combination of busulfan and cyclosphosphamide followed by an unpurged autologous BMT. Of 517 eligible patients, 367 had a CR, but only 219 (59.5%) actually received the planned intensive postremission treatment (73 allogeneic BMT, 75 autologous BMT, and 71 ICC). With a median follow-up of 62 months, the 4-year disease-free survival (DFS) of the 367 patients in CR was 39.5%. The 4-year overall survival (OS) of the 517 eligible patients was 40.5%. In multivariate analysis, DFS and OS were influenced only by the initial white blood cell count and by the French-American-British classification. The type of postremission therapy had no significant impact on the outcome. There was no difference in the 4-year DFS and OS between 88 patients for whom an allogeneic BMT was scheduled (respectively, 44% and 53%) and 134 patients of the same age category and without an HLA-identical sibling (respectively, 38% and 53%). Similarly, there was no difference in the outcome between autologous BMT and ICC. The 4-year DFS was 44% for the 86 patients randomly assigned to autologous BMT and 40% for the 78 patients assigned to ICC (P = .41). The 4-year OS was similar in the two groups (50% v 54.5%, P = .72). The median duration of hospitalization and thrombocytopenia were longer after autologous BMT (39 v 32 days, P = .006, and 109.5 v 18.5 days, P = .0001, respectively). After a first course of ICC, a second course of chemotherapy is less myelotoxic than an unpurged autologous BMT but yields comparable DFS and OS rates.     

Stress-induced γ→ α martensitic transformation in two carbon stainless steels. Application to trip steels

The influence of the temperature θαof a prestraining of austenite above M_don the subsequent stress-induced γ→ α’ transformation in the(M _s, M_d) range is examined in two carbon stainless steels. It is shown that the yield stress, which is controlled by the transformation, increases with θαat given testing temperature and amount of prestraining. This behavior is related to the influence of θαon the nature and arrangement of the defects present in austenite after the prestraining: planar defects(i.e., stacking faults, twins, e platelets) predominate if θαis close to M_dwhereas undissociated dislocation cells are only to be observed if θif higher. This is consistent with the strong increase of the intrinsic stacking fault energy of the austenite, as inferred from measurements using the node method on a hot stage microscope. In addition, the ability of plane defects to propagate under stress is shown to be lower after a prestraining at higher θα, which is attributed to a segregation of impurity atoms on dislocations. It is concluded that the nucleation stress of the γ→ α’ transformation is the stress necessary to allow planar defects to propagate in the prestrained austenite. This work is part of a thesis prepared at the Centre des Matériaux de l’Ecole des Mines, Corbeil, France, and submitted at the University of Nancy, June 1972.     

Heat transfer properties in a vertical channel filled with saturated and pressurized helium II

Various heat flow regimes were investigated in a vertical slit opened at both ends of a helium II bath, as a means of simulating the properties of a typical heat transfer channel in a superconducting device. In pressurized He II, the heat fluxes before the transition of He II of — He I are in agreement with the Gorter-Mellink model. In saturated He II, a heat transfer regime characterized by temperature oscillations superimposed on a Gorter-Mellink regime has been found.     

Unperturbed dimensions of polyacrylamide in salt-water-methanol mixtures

The unperturbed dimensions of polyacrylamide are determined by light scattering measurements, in methanol-water solutions and correspond to: R_G?=0.39±0.01 M^0.5. This result is compared to that obtained from viscosity measurements in aqueous solution, through Stockmayer-Fixmann method. A possible explanation based upon the recent blob theory of polymers is proposed for the observed differences.     

High performance stabilization in superfluid helium

A simple and automatic system for temperature stabilization, between 1.8 and 2.2 K, is presented. The thermometers used together in this system are a second or fourth sound cavity and a germanium resistance thermometer. One gives results showing a stability of better than 10^?8 degree.     

Coarse-to-Fine Face Detection

We study visual selection: Detect and roughly localize all instances of a generic object class, such as a face, in a greyscale scene, measuring performance in terms of computation and false alarms. Our approach is sequential testing which is coarse-to-fine in both in the exploration of poses and the representation of objects. All the tests are binary and indicate the presence or absence of loose spatial arrangements of oriented edge fragments. Starting from training examples, we recursively find larger and larger arrangements which are decomposable, which implies the probability of an arrangement appearing on an object decays slowly with its size. Detection means finding a sufficient number of arrangements of each size along a decreasing sequence of pose cells. At the beginning, the tests are simple and universal, accommodating many poses simultaneously, but the false alarm rate is relatively high. Eventually, the tests are more discriminating, but also more complex and dedicated to specific poses. As a result, the spatial distribution of processing is highly skewed and detection is rapid, but at the expense of (isolated) false alarms which, presumably, could be eliminated with localized, more intensive, processing.     

Computer design of super-orthogonal space-time trellis codes

Super-orthogonal space-time trellis codes (SOSTTCs) designed by hand can significantly improve the performance of space-time trellis codes. This paper introduces a new representation of SOSTTCs based on a generator matrix that allows a systematic and exhaustive search of all possible codes. This will verify that some of the known codes are optimal, and provides a means to easily implement encoders and decoders with a large number of states without relying on a graphical representation. New codes with up to 256 states that outperform previously known codes are presented