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北地里,千宅万户的屋梁受尽风欺雪压犹自温柔地抱着一团小小的燕巢。这是最温情的守候。人世间,千秋万代的屋梁穷尽一生之力,默默擎起身下各异的居所。这是最无私的担当。可古往今来,自喻有情的世人皆赞梁间燕,梁 相似文献
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Frank van der Hoeven 《Tunnelling and Underground Space Technology incorporating Trenchless Technology Research》2011,26(2):292-309
In the early 1990s, it became clear that tunnelling as Dutch engineers knew was about to change fundamentally. Local governments, pressure groups and individuals had become aware of the added value that underground space technology (tunnelling) could bring, giving rise to the next generation of multifunctional road and rail tunnel projects. This article reports on the outcome of a landmark study that focused on the new opportunities that multifunctional tunnels for motorways offer: RingRing. The RingRing study includes a concise state-of-the-art exploration of path-finding projects, delivers a solid methodology for dealing with the many design decisions during the conceptual phase of the multidisciplinary project, proposes a set of generic concepts that respond to the four key challenges faced by multifunctional tunnels, conducts two showcase design study projects, and provides an overall analysis of the applicability of multifunctional tunnels for integrating orbital motorways in large cities such as Amsterdam and Rotterdam. Eight years after the publication of the RingRing study, the first projects it identified are built. Others projects have not yet made it off the drawing board. This article looks back to assess what has been accomplished and draws lessons learned in order to be able to improve future projects. 相似文献
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Cancer Treatment: Photothermal Killing of Cancer Cells by the Controlled Plasmonic Coupling of Silica‐Coated Au/Fe2O3 Nanoaggregates (Adv. Funct. Mater. 19/2014) 下载免费PDF全文
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Kristian Kempe Sher Leen Ng Sylvia T. Gunawan Ka Fung Noi Frank Caruso 《Advanced functional materials》2014,24(39):6187-6194
The assembly of low‐fouling polymer capsules with redox‐responsive behavior and intracellular degradability is reported. Thiol‐containing poly(2‐ethyl‐2‐oxazoline) (PEtOxMASH) brushes are synthesized by atom transfer radical polymerization (ATRP) of oligo(2‐ethyl‐2‐oxazoline)methacrylate and glycidyl methacrylate (GMA) and subsequent ring‐opening reaction of the GMA. Sequential deposition of PEtOxMASH/poly(methacrylic acid) (PMA) multilayers onto silica (SiO2) particle templates and crosslinking through disulfide formation yield stable capsules after the removal of the SiO2 templates by buffered hydrofluoric acid (HF). The redox‐responsive nature of the disulfide crosslinking groups enables the degradation of these capsules under simulated intracellular conditions at pH 5.9 and 5 mm glutathione (GSH). Furthermore, capsule degradation is observed after incubation with dendritic (JAWS II) cells. Even at high capsule‐to‐cell ratios, PEtOxMASH capsules show only negligible cytotoxicity. Quartz crystal microgravimetry (QCM) studies, using 100% human serum, reveal that films prepared from PEtOxMASH exhibit low‐fouling properties. The degradation and low‐fouling properties are promising for application of PEtOxMASH films/capsules for the delivery and triggered release of therapeutics. 相似文献