Wearable music in engaging technologies

We address the relationship between a music performer and her instrument as a possible model for re-thinking wearable technologies. Both musical instruments and textiles invite participation and by engaging with them we intuitively develop a sense of their malleability, resistance and fragility. In the action of touching we not only sense, but more importantly we react. We adjust the nature of our touch according to a particular material’s property. In this paper we draw on musical practice as it suggests attitudes of specificity rather than adaptability. This practice exposes the design of generalised “multi-use” devices, such as the all-in-one electronic organ, as rooted in utilitarian thinking. We argue that this tendency ignores the complexities of musical cultures and thus fails to provide technologies, which provoke creative action rather than aim for the promise of control and efficiency.     

"Right-Trunkers" and "Left-Trunkers": Side Preferences of Trunk Movements in Wild Asian Elephants (Elephas maximus).

In this article, the side preferences of feeding-related trunk movements of free-ranging Asian elephants (Elephas maximus) were investigated for the first time. It is hypothesized that a functional asymmetry of the trunk is necessary to perform skillful feeding movements more efficiently. This might be connected with a corresponding hemispheric specialization. Video recordings of 41 wild elephants provided frequencies and durations of the following trunk-movement categories: object contact, retrieval, and reaching. In each category, individual side preferences were found. The strength of side preferences varied between the trunk-movement categories and the sexes. Mean durations of retrieval and reaching correlated negatively with the strength of side biases. Comparing the side preferences in the unpaired trunk with analogous phenomena in other unpaired grasping organs and in primate handedness. the authors discuss possible explanations for the evolution of asymmetries in unpaired grasping organs. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Immunological problems of transplantation into the subretinal space

The objective of retinal transplantation is to substitute destroyed or degenerated retina to improve visual function. Photoreceptors and retinal pigment epithelium cells of embryonic and nonembryonic origin have been transplanted into the subretinal space in different animal models. Recently, retinal cells have also been used for transplantation in untreated or immunosuppressed patients with retinitis pigmentosa and age-related macular degeneration. Transplants performed in animals such as the RCS rat have maintained retinal function at the transplantation site for long periods of time, although such transplantations in humans have not proved conclusively, to date, whether there is a real effect or not. One reason for this phenomenon seems to be an immune response to transplanted retinal cells at the transplantation site. The detectable rejection process shows that the posterior part of the eye is not absolutely immunologically privileged and that rejection is a serious problem in human retinal transplantation. Many questions concerning transplantation technique, graft treatment and postoperative treatment will be answered through more intensive experiments and clinical trials regarding the immunology. However, rejection of transplanted material is one of the main reasons why retinal transplantation has not yet proved successful.     

The Aggregation Pheromone of <Emphasis Type="Italic">Phyllotreta striolata</Emphasis> (Coleoptera: Chrysomelidae) Revisited

Aggregations of the striped flea beetle Phyllotreta striolata on their crucifer host plants are mediated by volatiles emitted from feeding males. The male-specific sesquiterpene, (6R,7S)-himachala-9,11-diene (compound A), was shown previously to be physiologically and behaviorally active, but compound A was attractive only when combined with unnaturally high doses of the host plant volatile allyl isothiocyanate (AITC) in field trapping experiments. This indicated that our understanding of the chemical communication in this species is incomplete. Another male-specific sesquiterpenoid, (3S,9R,9aS)-3-hydroxy-3,5,5,9-tetramethyl-5,6,7,8,9,9a-hexahydro-1H-benzo[7]annulen-2(3H)-one (compound G), has been reported from an American P. striolata population. We confirmed the presence of compound G, and investigated its interaction with compound A and AITC in a P. striolata population in Taiwan. Compound G was attractive to Taiwanese P. striolata in laboratory bioassays, but significantly more beetles were attracted to a blend of compounds A and G. Under the same conditions, P. striolata showed no preference for the blend of A and G combined with a range of doses of AITC over the sesquiterpenoid blend alone. The sesquiterpenoid blend was tested further in field trapping experiments and attracted significantly more beetles than traps baited with compound A and ecologically relevant amounts of AITC. We conclude that A and G are components of the male-specific aggregation pheromone of P. striolata in Taiwan, and that the attractiveness of the pheromone is not reliant on the presence of AITC. Our results further indicate that the male-specific sesquiterpenoid blends differ qualitatively between the Taiwanese and American populations of P. striolata.     

Visko‐elastisches Verhalten von Holz‐Klebstoff‐Verbindungen unter zyklischer Zug‐Druck‐Belastung

Visco‐elastic behavior of bonded wood under cyclic tensile and compression loading In the present contribution, a test method is used to simulate the static, cyclic loading of adhesive joints due to swelling and shrinking of the wood and to demonstrate the plastic deformation in the low load range. For tensile shear specimens prepared from beech wood and bonded with three different adhesives (MUF, PRF, PUR), the elastic behavior under cyclic tensile and compression loading was investigated and the loss and storage of energy was determined. All tested adhesives showed viscose parts even at a very low load level of 3 MPa. At a load level of 7 MPa, the PRF joints revealed a more elastic behavior than the other. The increased loss energy determined for the PUR bonding indicates a softening of the adhesive joint.     

Flexible and economical operation of chlor-alkali process with subsequent polyvinyl chloride production

Demand response (DR) can compensate for imbalances in variable renewable energy supplies. This possibility is particularly interesting for electrochemical processes, due to their high energy intensity. To determine the technical feasibility and economic viability of DR, we chose the chlor-alkali process with subsequent polyvinyl chloride production, including intermediate storage for ethylene dichloride. We estimate the maximum possible cost savings of implementing load flexibility measures. A process model is set up to determine the system characteristic. Subsequent optimizations result in the facility's best possible dispatch depending on additional and minimum power load, storage volume, and cost of a load change. Real plant data are used to specify model parameters and validate the system characteristic and the plant dispatch. An economic evaluation reveals the economic advantages of efficiency and flexibility. The approach can be used to analyze the DR potential of other chlorine value chains or facilities with high electricity demand in general.     

Molecular dynamics study of reaction pathways in an Al-coated Ni nanoparticle

Using molecular dynamics simulation in combination with an embedded atom method potential we analyze the alloying reaction in an Al-coated Ni nanoparticle with equi-atomic fractions and a diameter of about 9.5 nm. The first stage of the alloying reaction is controlled by interdiffusion between the f.c.c. Al-shell and f.c.c. Ni-core. Then, the large driving force for further alloying of Ni and Al promotes solid state amorphization of a supersaturated metastable f.c.c. Ni–Al solid solution in the vicinity of the interface region and, eventually, the whole shell of the nanoparticle. It is shown that there are at least two further possible pathways of the reaction. The first pathway occurs through crystallization of the amorphous shell into an Al-rich B2-NiAl phase before the complete dissolution of the f.c.c. Ni-core followed by interdiffusion between the Al-rich B2-NiAl shell and the f.c.c. Ni-core. A prediction is made that under certain conditions, interdiffusion between an Al-rich B2-NiAl shell and an f.c.c. Ni-core in such a nanoparticle may result in the formation of a hollow B2-NiAl nanoparticle. The second pathway leads to the complete dissolution of the f.c.c. Ni core in the growing amorphous Ni–Al shell. In order for this scenario to be realised the rate of temperature increase at the stage of dissolution of the f.c.c. Ni core in the growing amorphous Ni–Al shell should be higher than in the previous case. We also demonstrate some possibilities to control the self-heating rate at the stage of dissolution of the f.c.c. Ni core in the growing amorphous Ni–Al shell, which is important for a switching of the reaction pathways in a desired direction.     

Imidazole Analogs of Vascular-Disrupting Combretastatin A-4 with Pleiotropic Efficacy against Resistant Colorectal Cancer Models

Specific targeting of the tumoral vasculature by vascular-disrupting agents (VDA), of which combretastatin A-4 (CA-4) is a main representative, has been considered a new therapeutic strategy against multidrug-resistant tumors. In addition, CA-4 and analogs are tubulin-targeting agents and can exert direct antitumor effects by different mechanisms. Herein, we analyzed a series of synthetic CA-4 analogs featuring N-methylimidazole-bridged Z-alkenes with different halo- or amino-substituted aryl rings in vitro and in vivo, focusing on models of colorectal cancer. Combined in vitro/in vivo structure–activity relationship studies using cell lines and xenograft tumors susceptible to VDA-induced vascular damage demonstrated a clear association of cytotoxic and vascular-disrupting activity with the ability to inhibit tubulin polymerization, which was determined by specific substitution constellations. The most active compounds were tested in an extended panel of colorectal cancer (CRC) cell lines and showed activity in CA-4-resistant and chemotherapy-resistant cell lines. The bromo derivative brimamin was then compared with the known fosbretabulin (CA-4P) by activity tests on DLD-1- (multidrug-resistant) and HT29- (CA-4-resistant) derived xenograft tumors. Treatment did not induce pronounced vascular-disrupting effects in these tumors. Histological analyses revealed distinct tumor substructures and vessel compositions of DLD-1/HT29 tumors, which clearly differed from the tumor models susceptible to VDA treatment. Even so, brimamin effectively retarded the growth of DLD-1 tumors, overcoming their resistance to standard treatment, and it inhibited the outgrowth of disseminated HT29 tumor cells in an experimental metastasis model. In conclusion, combretastatin analogous N-methylimidazoles proved capable of inducing vascular-disrupting effects, comparable to those of CA-4P. In addition, they showed antitumor activities in models of drug-resistant colorectal cancer, independent of vascular-disrupting effects.     

Effects of a Cumulative,Suboptimal Supply of Multiple Trace Elements in Mice: Trace Element Status,Genomic Stability,Inflammation, and Epigenetics

Scope: Trace element (TE) deficiencies often occur accumulated, as nutritional intake is inadequate for several TEs, concurrently. Therefore, the impact of a suboptimal supply of iron, zinc, copper, iodine, and selenium on the TE status, health parameters, epigenetics, and genomic stability in mice are studied. Methods and results: Male mice receive reduced or adequate amounts of TEs for 9 weeks. The TE status is analyzed mass‐spectrometrically in serum and different tissues. Furthermore, gene and protein expression of TE biomarkers are assessed with focus on liver. Iron concentrations are most sensitive toward a reduced supply indicated by increased serum transferrin levels and altered hepatic expression of iron‐related genes. Reduced TE supply results in smaller weight gain but higher spleen and heart weights. Additionally, inflammatory mediators in serum and liver are increased together with hepatic genomic instability. However, global DNA (hydroxy)methylation is unaffected by the TE modulation. Conclusion: Despite homeostatic regulation of most TEs in response to a low intake, this condition still has substantial effects on health parameters. It appears that the liver and immune system react particularly sensitive toward changes in TE intake. The reduced Fe status might be the primary driver for the observed effects.