Evaluation of consecutively placed unloaded root-form and plate-form implants in adult Macaca mulatta monkeys

The present paper describes 18 consecutively-treated non-human primates (Macaca mulatta) as part of a balanced block design study of 36 animals to examine osseointegration in root- and plate-form implants prepared by atraumatic preparation of bone. Clinical measurements around selected teeth and digital radiology were utilized to monitor periodontal disease and bone deposition around the unloaded implants. Once a month scaling procedures were utilized as a means of preventing further advance of periodontal disease. Results indicate that once-monthly regimen of scaling and root planing can prevent attachment loss of natural teeth and will not interfere with the healing of either type of implant; once-monthly scalings produce significant reduction in redness (P < .05) and reduced probing depths (P = .01). A second finding is that both root and blade implants show radiographic evidence of osseointegration in this primate model. The quantitative analysis demonstrates bone gain is not stabilized until 6 months after healing. The data may indicate that occlusal loading of mandibular implants at 3 months may be premature.     

Pathogenesis of acute passive murine encephalomyelitis I. Importance of host-derived cells as determined by kinetic analysis

Kinetics of entry into the CNS of donor- and host-derived T-cells during the onset of acute murine EAE induced by the passive transfer of an encephalitogenic PLP(139-151)-specific T-cell clone was investigated. RT-PCR and spectratypic analysis of total RNA recovered from recipient mice demonstrated the presence in the CNS of donor- and host-derived T-cells 24 h post adoptive transfer. Donor-derived T-cells detected in the CNS decreased days 2-6 post transfer while host-derived T-cells persisted during this time. Beginning 3 days before clinical onset, an increase in the CNS of both T-cell populations was observed which persisted through disease onset. Similar analysis performed on recipients of an nonencephalitogenic PLP(139-151)-specific T-clone demonstrated a transient infiltration of donor- and host-derived T-cells beginning 4 days post transfer (dpt) and returning to background levels by day 7 post transfer. Results presented here suggest the importance of host-derived T-cells in the onset of acute passive murine EAE.     

Happiness and reminiscing: The role of time perspective, affect, and mode of thinking.

Conducted 3 experiments to determine the affect of reminiscing on reported well-being. 51 students at a professional school for translators and interpreters in Exp I and 36 undergraduates in Exp II recounted events that they had experienced as positive and pleasant or as negative and unpleasant. In Exp III, 64 undergraduates wrote down a particularly positive or negative event and then asked to explain either why or how this event occurred. Ss in all 3 experiments were then asked to rate their happiness and life satisfaction. Overall results indicate that Ss' ratings of general life satisfaction depended not only on the hedonic quality of the life experiences they happened to recall but also on the way in which they thought about them. Specifically, the hedonic quality of present life events influenced Ss' judgments of well-being in the same direction. The hedonic quality of past events, however, had a congruent impact on well-being judgments only when thinking about them elicited affect in the present but otherwise had a contrast effect on these judgments. Two factors were found to determine if thinking about the past elicits affect: whether Ss describe the events vividly and in detail or only mention them briefly, and whether Ss describe how the events occurred rather than why they occurred. (22 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Primary structure of the kinase domain region of rabbit skeletal and cardiac muscle titin

A 2.3 kb region of rabbit cardiac and skeletal muscle titin has been cloned. The cDNA sequences of the two tissues are identical and show 91% identity on the nucleotide level with the corresponding region of human cardiac muscle titin. On the amino acid level the identity is 96% and similarity is 98%. Alignment of predicted amino acid sequences of several homologous kinase domains reveals that the rabbit titin kinase has all the necessary elements of an active catalytic domain and carries a potential regulatory region on its C-terminal end. The distance of the 2.3 kb contig from the 3' end of the message was determined to be 5.7 kb in both tissues using oligonucleotide directed RNase H cleavage of titin mRNAs. This is essentially identical with the length of the fully sequenced human cardiac titin C-terminal end. It therefore appears unlikely that there are major tissue specific differences in this 8 kb cDNA region which encodes the C-terminus of rabbit skeletal and cardiac titin.     

Interrelationships in fatty acid processing

Examples are presented of the effect of each processing step on the quality, yield and throughput in the fatty acid processing scheme. These examples serve to illustrate the importance of seemingly unimportant process variables upon the economic involved in fatty acid processing.     

Noise analysis performed at the sodium cooled power reactor KNK I for malfunction diagnosis and plant surveillance

In order to use neutron noise analysis as an effective tool for early malfunction detection it is necessary to identify the driving forces and to calculate their contributions to the power fluctuations. In this paper the influence of a considerable number of measured noise sources on neutron noise within a large frequency range (10⁻³ Hz to 10³ Hz) is investigated for the sodium cooled power reactor KNK I (thermal core, 58 MW_th).

The experimental basis for the analysis is numerous records of the following signals at various power levels: neutron noise which has been measured with an in-core fission chamber and 3 ex-core ionisation chambers; the sodium inlet temperature and the coolant flow in both primary coolant loops and the movement of the control rods. In addition signals from acoustic-, seismic- and pressure transducers and the coolant outlet temperature were collected.

The influence of the thermohydraulic- and of the control system on neutron noise has also been calculated by means of the relations for linear and multiple-input systems. Important for this analysis is the reactivity-power transfer function. Calculations of this function could be confirmed by measurements using a pseudo-random binary signal as reactivity input.

The following results were obtained from the analysis of the auto-power spectral densities of the neutron flux: Fluctuations of the coolant inlet temperature and the coolant flow are relatively small sources for neutron noise. However, reactivity adjustments resulting from the automatic control system because of the inherent instability of the reactor turned out to be an important driving force.

The influence of still unknown driving forces increased considerably with the reactor power. Since the coolant flow was proportional to the reactor power in order to keep the coolant temperature constant, this result indicates that turbulent flow must have induced stochastical movements of core components. These movements are considered to have mainly caused the unknown reactivity driving forces. Their magnitude could be determined reliably only in the frequency range, in which external feedback mechanisms through the primary coolant system were negligible. For 30 to 50 % reactor power the contribution was about 30 % (for f > 5·10⁻³ Hz) and for full power it increased to about 80 % (for f > 5·10⁻² Hz) of the measured neutron noise. For frequencies > 5 Hz the white detection noise prevails. Single peaks in this frequency region could be explained by coherence function investigations between in-core and ex-core neutron detector signals and by correlation of these signals with displacement- and pressure fluctuations.

Though the measured neutron noise could not be unambiguously related to driving forces, the combination of analytical and empirical methods makes the results also applicable for the design of surveillance techniques for other sodium cooled reactors (e.g. LMFBRs). Examples for possible applications are given.