古龙南凹陷葡萄花油层致密油成藏机理研究

古龙南凹陷葡萄花油层油水关系复杂,由凹陷中心向四周表现为致密油藏-油水过渡带-常规油藏的特点。通过沉积微相、储层微观孔隙特征、成岩作用、恒速压汞实验、相渗实验研究可知,凹陷中心区以三角州前缘席状砂为主,北部和西部物源交互沉积,形成了条带状或透镜状砂体。砂体泥质含量较高,成岩作用较强,储层岩石亲油。凹陷内储层喉道半径大于构造高部位区储层喉道半径,且分选性较差;凹陷区储层孔隙半径小于高部位区储层孔隙半径,且分选性较好。凹陷区储油空间以喉道为主,凹陷区内储层孔隙、喉道数量较少,孔喉半径比相对较小,孔隙连通性较差;构造高部位区储油空间以孔隙为主,储层孔隙、喉道数量较多,孔喉半径比较大,孔隙连通性较好;石油成藏动力以喉道毛管力与下伏地层生烃压力为主。     

银铜双金属纳米合金的制备和电催化性质

采用电沉积方法制备银铜双金属纳米合金,用X射线衍射仪（XRD）及高分辨率透射电子显微镜（HRTEM）,扫描电子显微镜（SEM）和电化学工作站分别对样品的结构、微观形貌和电催化性质进行了表征。结果表明,银铜双金属纳米合金电极在H₂O₂溶液中表现出较强的还原电流,可以作为阴极催化剂;随着银铜双金属纳米合金沉积电位的变负,阴极催化作用减弱,形貌由穗状晶向树枝晶转变;随着铜离子浓度的提高,阴极催化作用增强,银铜双金属纳米合金的形貌由树枝晶向棒状晶转变。这意味着,本文观察到了银铜双金属纳米合金的双金属电催化协同效应。     

3500mm精轧机轧制力测压头技术改造

介绍了中厚板厂3500mm四辊精轧机轧制力测压头的改造方案,并对其进行分析,这对于提高中厚板轧机测压头的使用寿命和轧制力的测量精度具有重要意义。     

双稳铌酸锂电光调制器的超线性调制

本文分析了双调制晶体结构的双稳铌酸锂电光调制器的双稳以及超线性调制特性,通过数值分析方法讨论了光电转换因子对双稳的形成,双稳区域和线性调制对比度的影响,得到了与理论分析相吻合的实验结果。     

Reversal of Peripheral Neuropathic Pain by the Small-Molecule Natural Product Narirutin via Block of Nav1.7 Voltage-Gated Sodium Channel

Neuropathic pain is a refractory chronic disease affecting millions of people worldwide. Given that present painkillers have poor efficacy or severe side effects, developing novel analgesics is badly needed. The multiplex structure of active ingredients isolated from natural products provides a new source for phytochemical compound synthesis. Here, we identified a natural product, Narirutin, a flavonoid compound isolated from the Citrus unshiu, showing antinociceptive effects in rodent models of neuropathic pain. Using calcium imaging, whole-cell electrophysiology, western blotting, and immunofluorescence, we uncovered a molecular target for Narirutin’s antinociceptive actions. We found that Narirutin (i) inhibits Veratridine-triggered nociceptor activities in L4-L6 rat dorsal root ganglion (DRG) neurons, (ii) blocks voltage-gated sodium (Na_V) channels subtype 1.7 in both small-diameter DRG nociceptive neurons and human embryonic kidney (HEK) 293 cell line, (iii) does not affect tetrodotoxin-resistant (TTX-R) Na_V channels, and (iv) blunts the upregulation of Na_v1.7 in calcitonin gene-related peptide (CGRP)-labeled DRG sensory neurons after spared nerve injury (SNI) surgery. Identifying Na_v1.7 as a molecular target of Narirutin may further clarify the analgesic mechanism of natural flavonoid compounds and provide an optimal idea to produce novel selective and efficient analgesic drugs.     

轴流式喷水推进器启动过程的瞬态特性

为分析轴流式喷水推进器启动过程的瞬态特性和自吸性能,提高启动过程轴流式喷水推进器的推进性能,开展了推进器启动过程的数值计算研究.在雷诺时均Navier-Stokes方程框架下采用SST k-ω湍流模型、Zwart空化模型和Free Surface模型对轴流式喷水推进器的启动过程进行数值计算,分析启动时间和水线高度对喷水...     

Wearable,Self-powered,Drug-Loaded Electronic Microneedles for Accelerated Tissue Repair of Inflammatory Skin Disorders

Electrical stimulation (ES) is widely used in physiological and medical sciences, while its application to treat inflammatory skin diseases (ISDs) remains a challenge owing to their natural pathological cuticle barrier and lack of an effective combination with chemotherapy to achieve specific immunomodulation. Here, a wearable, battery-free, multi-component drug-loaded electronic microneedle (mD-eMN) system is developed by integrating remodeled metal microneedles loaded with multi-component chemical drugs and flexible triboelectric nanogenerators (TENGs). The system can rapidly release drugs into the site of ISDs and then realize an efficient penetration into cell body and specific immunomodulation under the synergism of pulsed electrons originating from the TENG. Also, the pulsed electrons can promote skin tissue homeostasis reconstruction to alleviate the inflammatory process of ISDs. Sufficient evidence shows that a significant skin inflammation regression of psoriasis (a typical ISDs model) is achieved using the mD-eMN system compared to traditional ES or chemotherapy alone. This innovative wearable mD-eMN system provides an effective flexible electronic and chemical drug joint technological platform for the treatment of ISDs, which is not only suitable for the treatment of psoriasis in this study but also maybe for other ISDs such as diabetic ulcers and skin tumors.