Effect of puerarin on the P13K pathway for glucose transportation and insulin signal transduction in adipocytes

To explore the effect of puerarin on insulin receptor (IR), insulin receptor substrate-1 (IRS-1) and protein expression of protein kinase B(PKB) in the P13K pathway of the glucose consumption, transportation and insulin signal transduction in 3T3-L1 adipocytes with insulin resistance. The insulin resistance 3T3-L1 adipocytes model was established by free fatty acid induction. The model cells were managed with puerarin in different concentrations. Glucose consumption was detected with glucose oxidase method, glucose transportation rate was determined by 2-deoxy-3H glucose ingesting method, and the IR, IRS-1 and PKB expression were determined by Western blot. Glucose consumption and transportation were significantly decreased in the model adipocytes, but increased after treated with puerarin (P<0.01). Moreover, the level of tyrosine phosphorylation of IR subunit β was higher in the puerarin treated groups, and that of IRS-1 was higher in the group treated with low dose puerarin than that in the model group. The 3T3-L1 adipocytes of insulin resistance model could be induced by free fatty acid successfully, puerarin could promote the glucose utilization in them to alleviate the insulin resistance, which may be related with the action in advancing the tyrosine phosphorylation of IR and IRS-1.     

Damage and deterioration mechanism and curing technique of concrete structure in main coal cleaning plants

Concrete structures in main coal cleaning plants have been rebuilt and reinforced in the coal mines of the Shanghai Da-tun Energy Sources Co. Ltd., the first colliery of the Pingdingshan Coal Co. Ltd. and the Sanhejian mine of the Xuzhou Mining Group Co. Ltd. In these projects, the operating environment and reliability of concrete structures in the main plants of the three companies were investigated and the safety of the structures inspected. Qualitative and quantitative analyses were made on the spe-cial natural, technological and mechanical environments around the structures. On the basis of these analyses, we discuss the long-term, combined actions of the harsh natural (corrosive gases, liquids and solids) and mechanical environments on concrete structures and further investigated the damage and deteriorating mechanisms and curing techniques of concrete structures in the main coal cleaning plants. Our study can provide a theoretical basis for ensuring the reliability of concrete structures in main coal cleaning plants.     

营运资金安全性与管理效率评价

基于风险收益权衡原则,构建了营运资金评价体系,特别指出营运资金评价应包括安全性与管理绩效性两个方面,并重点对此进行了研究,从中提出了一些改进营运资金财务分析的看法与建议,以期为企业改进营运资金管理掌控营运资金循环、为更好服务于保护债权人利益和所有者利益目标提供实现途径.     

高等院校开展学生职业生涯规划教育的思考

职业生涯规划对于人生发展具有极为重要的指导意义,对在校大学生进行职业生涯规划教育和指导,是高等学校人才培养的一项重要环节。文章针对高校学生对今后从业的认知现状和目前高校在开展就业教育工作中存在的不足,提出高等学校必须通过全程化和系统化的职业生涯规划教育指导,有效帮助学生发现和挖掘自身潜能,引导学生根据所学专业和个人志向及特长,设定毕业后的从业方向,确立大学不同阶段的努力目标,指导学生根据社会和个人发展的实际情况,实时修正从业方向和努力目标。在不断完善学生综合素质和专业技能的基础上,促进学生顺利完成学业、从容走向社会、尽早实现人生价值。     

异构多核处理器的任务分配及能耗的研究*

异构多核处理器采用不同的任务分配与调度算法,会导致不同的时间消耗与能量消耗,采用合适的任务分配与调度算法能节省较多的能耗。目前普遍认为最有发展前途的任务分配与调度技术是先用启发式方法进行分组,然后再用遗传算法进行调度。在改进任务分组后,又首次提出了用遗传算法解决能耗问题。实验结果表明在实时要求不高的情况下,能以较小的时间代价来节省较多的能耗。     

一种光纤陀螺随机漂移的高精度建模方法

为减小光纤陀螺随机漂移,采用时间序列分析法对其进行ARMA模型辨识.提出一种全局最优的模型阶次搜索算法,将模型适用性检验方法中的BIC(Bayesian information criterion)用于模型阶次搜索,并采用Pandit-Wu建模思想,把二维搜索化为一维搜索,得到了模型阶次的一致性估计.提出了一种改进的U-C算法,并与长自回归模型计算残差法相结合共同估计模型参数.它将非线性参数估计过程转化为线性过程,使用了正置与逆置漂移时序参与估计,以前向和后向模型的滤波误差平方和最小为参数估计的指标,在p+1维空间中求极小值.采用上述方法确定的模型其残差标准差为0.002 4°,最大预报误差为0.011 2°,能准确预报光纤陀螺随机漂移趋势.     

相转移催化合成癸二酸二甲酯

使用相转移催化剂BTEAC(氯化三乙基苄胺 )合成癸二酸二甲酯。条件为 :10g癸二酸 ,80mL甲醇 ,0 .5mL硫酸 ( 98% )和 0 .0 5gBTEAC。癸二酸二甲酯产率达到 90 .4 %     

全媒体时代新闻学专业实践教学模式的研究

全媒体时代,需要全媒体型新闻传播人才。新闻学专业教育者,要顺应时代要求,转变教育、教学观念,不断探索教学模式,加大实践教学内容比重,使课堂理论知识和实践教学环节相融合。营造多层次的实践平台,注重单项实践与综合实训相结合,增加"双师型"的教师比例,提高实践教学质量。     

基于MSP430单片机的灾害性天气预警管理系统设计

设计了基于MSP430单片机的灾害性天气预警管理系统,针对常见的雨量、风速及温度自然因素实现实时的监测,并对数据进行分析和处理,设置出相应的警报等级,并能根据警报的等级控制相应的三路设备。     

Temperature stability and fracture toughness of Nd-Fe-B magnets

Temperature stability and toughness of magnets are very important properties especially for application in motor. In this paper, it is found that temperature stability and toughness of magnets are improved when Fe is substituted with Co andheavy rare earth is substituted for Nd in part and suitable rich B grain-boundary phase is added. In addition, heavy rare earth substitution decreases the remanence temperature coefficient greatly, but has a little effect on Curie temperature of the magnets, which is beneficial to Nd-Fe-B magnets for the application in motor.