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131.
Chiara Bellocchi Angelica Carandina Beatrice Montinaro Elena Targetti Ludovico Furlan Gabriel Dias Rodrigues Eleonora Tobaldini Nicola Montano 《International journal of molecular sciences》2022,23(5)
The autonomic nervous system (ANS) and the immune system are deeply interrelated. The ANS regulates both innate and adaptive immunity through the sympathetic and parasympathetic branches, and an imbalance in this system can determine an altered inflammatory response as typically observed in chronic conditions such as systemic autoimmune diseases. Rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis all show a dysfunction of the ANS that is mutually related to the increase in inflammation and cardiovascular risk. Moreover, an interaction between ANS and the gut microbiota has direct effects on inflammation homeostasis. Recently vagal stimulation techniques have emerged as an unprecedented possibility to reduce ANS dysfunction, especially in chronic diseases characterized by pain and a decreased quality of life as well as in chronic inflammation. 相似文献
132.
Mohamed Haddad Roger Gaudreault Gabriel Sasseville Phuong Trang Nguyen Hannah Wiebe Theo Van De Ven Steve Bourgault Normand Mousseau Charles Ramassamy 《International journal of molecular sciences》2022,23(5)
The overall impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on our society is unprecedented. The identification of small natural ligands that could prevent the entry and/or replication of the coronavirus remains a pertinent approach to fight the coronavirus disease (COVID-19) pandemic. Previously, we showed that the phenolic compounds corilagin and 1,3,6-tri-O-galloyl-β-D-glucose (TGG) inhibit the interaction between the SARS-CoV-2 spike protein receptor binding domain (RBD) and angiotensin-converting enzyme 2 (ACE2), the SARS-CoV-2 target receptor on the cell membrane of the host organism. Building on these promising results, we now assess the effects of these phenolic ligands on two other crucial targets involved in SARS-CoV-2 cell entry and replication, respectively: transmembrane protease serine 2 (TMPRSS2) and 3-chymotrypsin like protease (3CLpro) inhibitors. Since corilagin, TGG, and tannic acid (TA) share many physicochemical and structural properties, we investigate the binding of TA to these targets. In this work, a combination of experimental methods (biochemical inhibition assays, surface plasmon resonance, and quartz crystal microbalance with dissipation monitoring) confirms the potential role of TA in the prevention of SARS-CoV-2 infectivity through the inhibition of extracellular RBD/ACE2 interactions and TMPRSS2 and 3CLpro activity. Moreover, molecular docking prediction followed by dynamic simulation and molecular mechanics Poisson–Boltzmann surface area (MMPBSA) free energy calculation also shows that TA binds to RBD, TMPRSS2, and 3CLpro with higher affinities than TGG and corilagin. Overall, these results suggest that naturally occurring TA is a promising candidate to prevent and inhibit the infectivity of SARS-CoV-2. 相似文献
133.
Marialuisa Aragona Caterina Porcino Maria Cristina Guerrera Giuseppe Montalbano Rosaria Laur Marzio Cometa Maria Levanti Francesco Abbate Teresa Cobo Gabriel Capitelli Jos A. Vega Antonino German 《International journal of molecular sciences》2022,23(5)
The brain-derived neurotrophic factor (BDNF) was discovered in the last century, and identified as a member of the neurotrophin family. BDNF shares approximately 50% of its amino acid with other neurotrophins such as NGF, NT-3 and NT-4/5, and its linear amino acid sequences in zebrafish (Danio rerio) and human are 91% identical. BDNF functions can be mediated by two categories of receptors: p75NTR and Trk. Intriguingly, BDNF receptors were highly conserved in the process of evolution, as were the other NTs’ receptors. In this review, we update current knowledge about the distribution and functions of the BDNF-TrkB system in the sensory organs of zebrafish. In fish, particularly in zebrafish, the distribution and functions of BDNF and TrkB in the brain have been widely studied. Both components of the system, associated or segregated, are also present outside the central nervous system, especially in sensory organs including the inner ear, lateral line system, retina, taste buds and olfactory epithelium. 相似文献
134.
Sanghee Lee Theresa R. Mendoza Danielle N. Burner Michelle T. Muldong Christina C. N. Wu Catalina Arreola-Villanueva Abril Zuniga Olga Greenburg William Y. Zhu Jamillah Murtadha Evodie Koutouan Naomi Pineda Hao Pham Sung-Gu Kang Hyun Tae Kim Gabriel Pineda Kathleen M. Lennon Nicholas A. Cacalano Catriona H. M. Jamieson Christopher J. Kane Anna A. Kulidjian Terry Gaasterland Christina A. M. Jamieson 《International journal of molecular sciences》2022,23(6)
135.
Gabriel S.Esterhuizen I.Berk Tulu Dave F.Gearhart Heather Dougherty Mark Van Dyke 《矿业科学技术学报(英文版)》2021,31(1):103-110
Longwall gateroad entries are subject to changing horizontal and vertical stress induced by redistribution of loads around the extracted panel. The stress changes can result in significant deformation of the entries that may include roof sag, rib dilation, and floor heave. Mine operators install different types of supports to control the ground response and maintain safe access and ventilation of the longwall face. This paper describes recent research aimed at quantifying the effect of longwall-induced stress changes on ground stability and using the information to assess support alternatives. The research included monitoring of ground and support interaction at several operating longwall mines in the U.S., analysis and calibration of numerical models that adequately represent the bedded rock mass, and observation of the support systems and their response to changes in stress. The models were then used to investigate the impact of geology and stress conditions on ground deformation and support response for various depths of cover and geologic scenarios. The research results were summarized in two regression equations that can be used to estimate the likely roof deformation and height of roof yield due to longwall-induced stress changes. This information is then used to assess the ability of support systems to maintain the stability of the roof. The application of the method is demonstrated with a retrospective analysis of the support performance at an operating longwall mine that experienced a headgate roof fall. The method is shown to produce realistic estimates of gateroad entry stability and support performance, allowing alternative support systems to be assessed during the design and planning stage of longwall operations. 相似文献
136.
Flaviu Tma Rodica Blaa Doina Manu Gabriel Gyorki Rare Chinezu Corina Tma Adrian Blaa 《International journal of molecular sciences》2022,23(3)
Brain metastases represent more than 50% of all cerebral tumors encountered in clinical practice. Recently, there has been increased interest in the study of extracellular vesicles, and the knowledge about exosomes is constantly expanding. Exosomes are drivers for organotropic metastatic spread, playing important roles in the brain metastatic process by increasing the permeability of the blood–brain barrier and preparing the premetastatic niche. The promising results of the latest experimental studies raise the possibility of one day using exosomes for liquid biopsies or as drug carriers, contributing to early diagnosis and improving the efficacy of chemotherapy in patients with brain metastases. In this review, we attempted to summarize the latest knowledge about the role of exosomes in the brain metastatic process and future research directions for the use of exosomes in patients suffering from brain metastatic disease. 相似文献
137.
Luciano C. Ramires Gabriel Silva Santos Rafaela Pereira Ramires Lucas Furtado da Fonseca Madhan Jeyaraman Sathish Muthu Anna Vitria Lana Gabriel Azzini Curtis Scott Smith Jos Fbio Lana 《International journal of molecular sciences》2022,23(3)
Some say that all diseases begin in the gut. Interestingly, this concept is actually quite old, since it is attributed to the Ancient Greek physician Hippocrates, who proposed the hypothesis nearly 2500 years ago. The continuous breakthroughs in modern medicine have transformed our classic understanding of the gastrointestinal tract (GIT) and human health. Although the gut microbiota (GMB) has proven to be a core component of human health under standard metabolic conditions, there is now also a strong link connecting the composition and function of the GMB to the development of numerous diseases, especially the ones of musculoskeletal nature. The symbiotic microbes that reside in the gastrointestinal tract are very sensitive to biochemical stimuli and may respond in many different ways depending on the nature of these biological signals. Certain variables such as nutrition and physical modulation can either enhance or disrupt the equilibrium between the various species of gut microbes. In fact, fat-rich diets can cause dysbiosis, which decreases the number of protective bacteria and compromises the integrity of the epithelial barrier in the GIT. Overgrowth of pathogenic microbes then release higher quantities of toxic metabolites into the circulatory system, especially the pro-inflammatory cytokines detected in osteoarthritis (OA), thereby promoting inflammation and the initiation of many disease processes throughout the body. Although many studies link OA with GMB perturbations, further research is still needed. 相似文献
138.
Thamara Thaiane da Silva Gabriel Batista Cesar Carolina Pereira Francisco Guilherme Galerani Mossini Lidiane Vizioli de Castro Hoshino Francielle Sato Eduardo Radovanovic Deuber Lincon da Silva Agostini Wilker Caetano Luzmarina Hernandes Graciette Matioli 《应用聚合物科学杂志》2020,137(9):48415
The application of fibers associated with drugs is a promising alternative to meet the clinical needs of tissue repair. Curcumin exhibits great cicatricial potential because it has numerous pharmacological properties. This research aimed to produce fibers of polycaprolactone and copolymer F-108 associated with curcumin and to evaluate in vivo their action on the process of wound healing. The fibers were produced by electrospinning technique and characterized by scanning electron microscopy (SEM), X-ray diffractometry (XRD), and fluorescence microscopy. They were applied in cutaneous wounds of rats for the analysis of photoacoustic permeation and histological study. The characterization showed that the electrospinning allowed the preparation of homogeneous material with curcumin. The fibers benefited healing of the wounds and allowed the permeation of curcumin at all stages. The use of PCL/F-108 fibers allowed the elaboration of a new curcumin delivery system, improving its bioavailability and action in the healing of excisional wound. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020 , 137, 48415. 相似文献
139.
A study is reported on the effect of the filler size and concentration on the electrical resistivity, density, and hardness of composites made of copper powder embedded in nylon 6 matrix by means of compression molding. The electrical resistivity of the composites is > 1011 ohm·cm unless the metal content reached the percolation threshold, beyond which the resistivity decreased markedly by as much as 1012. The percolation concentration was found to decrease with a decrease in the average particle diameter. The density of the composites was measured and compared with values calculated assuming different void levels within the samples. However, there is no sharp variation in the density due to the onset of percolation. Furthermore, it is shown that a percolation concentration can be also defined in the hardness/metal concentration curves as the intercept of linear regression curves of the low and high metal content regimes, respectively. 相似文献
140.
Brazilian city beaches are public spaces favoring citizens well-being. Urban studies relate built form and infrastructure with urban vitality and coastal studies underline uses as important for beach management, yet few researches relate form and infrastructure with beach uses. Understanding daily life as essential for public spaces and that spatial form relates with uses, this paper assesses time-based relationships between built and natural physical attributes and social life on the beaches of João Pessoa, a coastal city in North-east Brazil. Physical attributes are investigated at city scale - beach type, street network centrality and topography - and seafront scale - land uses, public/private interfaces, public infrastructure, beach sections and water quality. Beach social life was surveyed online, enquiring peoples' beach choice, visiting time and place, activities and evaluation. Infrastructure and street network follow topography and help configure shore and promenade for different landscapes. More central beaches have diverse land uses, well-equipped promenades and lighting and were popular night and day, while less central beaches had less infrastructure and were visited only by day. Findings highlight how physical attributes facilitate uses and, together with peoples’ evaluation, can inform urban beach design and planning. 相似文献