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131.
Eduardo Aguilera Roberto Cioni Fabrizio Gherardi Gabriella Magro Luigi Marini Zhonghe Pang 《Geothermics》2005,34(4):495-517
The parent geothermal water proposed for the Chachimbiro geothermal area has calculated values of 2250 mg/L Cl and approximately 5 bar PCO2. It comes from a reservoir having an estimated temperature of 225–235 °C, although temperatures somewhat higher than 260 °C may be present at the roots of the system. The geothermal reservoir at Chachimbiro is recharged mainly by meteoric water (about 92%) and secondarily by arc-type magmatic water. Carbon and sulfur isotope data support a magmatic origin for the C and S species entering the geothermal system from below, consistent with indications provided by He isotopes.The thermal springs of Na–Cl to Na–Cl–HCO3 type located in the Chachimbiro area originate through dilution of the parent geothermal water and have reached different degrees of re-equilibration with country rocks at lower temperatures. 相似文献
132.
Experimenting with both mixture components and process variables, especially when there is likely to be interaction between these two sets of variables, is discussed. We consider both design and analysis questions within the context of addressing an actual mixture/process problem. We focus on a strategy for attacking such problems, as opposed to finding the best possible design or best possible model for a given set of data. In this sense, a statistical engineering framework is used. In particular, when we consider the potential of fitting parsimonious linear additive or nonlinear models as opposed to larger linearized models, we find potential to reduce the size of experimental designs. It is difficult in practice to know what type of model will best fit the resulting data. Therefore, an integrated, sequential design and analysis strategy is recommended. Using two published data sets and one new data set, we find that in some cases nonlinear models, or linear additive models —with no process/mixture interaction terms, enable reduction of experimentation on the order of 50%. In other cases, additive or nonlinear models will not suffice. We therefore provide guidelines as to when such an approach is likely to succeed, and propose an overall strategy for these types of problems. 相似文献
133.
From wheat sourdough to gluten‐free sourdough: a non‐conventional process for producing gluten‐free bread 下载免费PDF全文
Alessandra Marti Gabriella Bottega Laura Franzetti Francesca Morandin Lucio Quaglia Maria Ambrogina Pagani 《International Journal of Food Science & Technology》2015,50(5):1268-1274
Gluten‐free (GF) sourdough was prepared from wheat sourdough and analysed both in fresh (GFS) and dried forms (DGFS). The gluten content in each GF sourdough sample was <20 mg kg?1. The dough leavening capacity and the properties of the bread samples were investigated and compared to those of bread prepared using bakery yeast (Saccharomyces cerevisiae). Two commercial rice‐based mixtures (different for the presence/absence of buckwheat flour) were used to prepare bread samples. In GFS, lactic acid bacteria (LAB) and yeasts were found in amounts corresponding to 108 and 107 CFU g?1, respectively, whereas both LAB and yeasts were detected in lower amounts (about 106 CFU g?1) in DGFS. When used in bread‐making, both GFS types produced significant dough acidification and exhibited good dough development during proofing, resulting in loaves with specific volume values between 3.00 and 4.12 mL g?1, values similar to those obtained for reference bread (3.05÷4.15 mL g?1). The use of GFS was effective in lowering the bread staling rate during storage for up to 7 days. 相似文献
134.
Gabriella Bretti Roberto Natalini Benedetto Piccoli 《Archives of Computational Methods in Engineering》2007,14(2):139-172
We consider a mathematical model for fluid-dynamic flows on networks which is based on conservation laws. Road networks are
studied as graphs composed by arcs that meet at some nodes, corresponding to junctions, which play a key-role. Indeed interactions
occur at junctions and there the problem is underdetermined. The approximation of scalar conservation laws along arcs is carried
out by using conservative methods, such as the classical Godunov scheme and the more recent discrete velocities kinetic schemes
with the use of suitable boundary conditions at junctions. Riemann problems are solved by means of a simulation algorithm
which processes each junction. We present the algorithm and its application to some simple test cases and to portions of urban
network. 相似文献
135.
136.
Elena Orban Teresina Nevigato Maurizio Masci Gabriella Di Lena Irene Casini Roberto Caproni Loretta Gambelli Paola De Angelis Massimo Rampacci 《Food chemistry》2007,100(2):482-490
European perch (Perca fluviatilis) harvested from three lakes of Central Italy were studied in different seasonal periods of a year to evaluate their nutritional quality and some safety aspects related to the pollution of the aquatic environment. The lakes considered, located in the Latium region, differed with respect to their volcanic (Bolsena and Bracciano Lakes) or artificial (Salto Lake) origin. Fillets of fish caught in the three lakes were characterised by good protein (17–19%) and mineral contents and low lipid levels (0.6–1.2%) throughout the year. Total lipids were characterised by low cholesterol levels (41.9–74.7 mg/100 g) and high percentages of total n − 3 polyunsaturated fatty acids (27.7–33.8% of total fatty acids), in particular docosahexaenoic acid (14.2–25.3% of total fatty acids). The qualitative analysis of the stomach content of perch confirmed their predatory feeding behaviour. The chemical and nutritional profiles of perch from the three lakes were comparable except for rubidium and cesium levels, which were higher in the muscle tissues of perch from the volcanic lakes. These minerals may represent elements of traceability of the origin of fish. Low levels of organochlorine pesticides and polychlorinated biphenyls, well below the Italian and European action limits, were detected in the muscle tissue of perch from all three lakes. 相似文献
137.
138.
Marianna Gabriella Rispoli Silvia Valentinuzzi Giovanna De Luca Piero Del Boccio Luca Federici Maria Di Ioia Anna Digiovanni Eleonora Agata Grasso Valeria Pozzilli Alessandro Villani Antonio Maria Chiarelli Marco Onofrj Richard G. Wise Damiana Pieragostino Valentina Tomassini 《International journal of molecular sciences》2021,22(20)
Metabolomics-based technologies map in vivo biochemical changes that may be used as early indicators of pathological abnormalities prior to the development of clinical symptoms in neurological conditions. Metabolomics may also reveal biochemical pathways implicated in tissue dysfunction and damage and thus assist in the development of novel targeted therapeutics for neuroinflammation and neurodegeneration. Metabolomics holds promise as a non-invasive, high-throughput and cost-effective tool for early diagnosis, follow-up and monitoring of treatment response in multiple sclerosis (MS), in combination with clinical and imaging measures. In this review, we offer evidence in support of the potential of metabolomics as a biomarker and drug discovery tool in MS. We also use pathway analysis of metabolites that are described as potential biomarkers in the literature of MS biofluids to identify the most promising molecules and upstream regulators, and show novel, still unexplored metabolic pathways, whose investigation may open novel avenues of research. 相似文献
139.
Ewa esawska Waldemar Tejchman Annamria Kincses Gabriella Spengler Wojciech Nitek Grzegorz uchowski Ewa Szymaska 《International journal of molecular sciences》2022,23(18)
Multidrug resistance (MDR) is considered one of the major mechanisms responsible for the failure of numerous anticancer and antiviral chemotherapies. Various strategies to overcome the MDR phenomenon have been developed, and one of the most attractive research directions is focused on the inhibition of MDR transporters, membrane proteins that extrude cytotoxic drugs from living cells. Here, we report the results of our studies on a series newly synthesized of 5-arylidenerhodanines and their ability to inhibit the ABCB1 efflux pump in mouse T-lymphoma cancer cells. In the series, compounds possessing a triphenylamine moiety and the carboxyl group in their structure were of particular interest. These amphiphilic compounds showed over 17-fold stronger efflux pump inhibitory effects than verapamil. The cytotoxic and antiproliferative effects of target rhodanines on T-lymphoma cells were also investigated. A putative binding mode for 11, one of the most potent P-gp inhibitors tested here, was predicted by molecular docking studies and discussed with regard to the binding mode of verapamil. 相似文献
140.
Letizia Crocetti Gabriella Guerrini Fabrizio Melani Claudia Vergelli Maria Paola Mascia Maria Paola Giovannoni 《International journal of molecular sciences》2022,23(21)
As a continuation of our study in the GABAA receptor modulators field, we report the design and synthesis of new 8-chloropyrazolo[1,5-a]quinazoline derivatives. Molecular docking studies and the evaluation of the ‘Proximity Frequencies’ (exploiting our reported model) were performed on all the final compounds (3, 4, 6a–c, 7a,b, 8, 9, 12a–c, 13a,b, 14–19) to predict their profile on the α1β2γ2-GABAAR subtype. Furthermore, to verify whether the information coming from this virtual model was valid and, at the same time, to complete the study on this series, we evaluated the effects of compounds (1–100 µM) on the modulation of GABAA receptor function through electrophysiological techniques on recombinant α1β2γ2L-GABAA receptors expressed in Xenopus laevis oocytes. The matching between the virtual prediction and the electrophysiological tests makes our model a useful tool for the study of GABAA receptor modulators. 相似文献