DISTRIBUTION AND ABUNDANCE OF STREAM FISHES IN RELATION TO BARRIERS: IMPLICATIONS FOR MONITORING STREAM RECOVERY AFTER BARRIER REMOVAL

Dams are ubiquitous in coastal regions and have altered stream habitats and the distribution and abundance of stream fishes in those habitats by disrupting hydrology, temperature regime and habitat connectivity. Dam removal is a common restoration tool, but often the response of the fish assemblage is not monitored rigorously. Sedgeunkedunk Stream, a small tributary to the Penobscot River (Maine, USA), has been the focus of a restoration effort that includes the removal of two low‐head dams. In this study, we quantified fish assemblage metrics along a longitudinal gradient in Sedgeunkedunk Stream and also in a nearby reference stream. By establishing pre‐removal baseline conditions and associated variability and the conditions and variability immediately following removal, we can characterize future changes in the system associated with dam removal. Over 2 years prior to dam removal, species richness and abundance in Sedgeunkedunk Stream were highest downstream of the lowest dam, lowest immediately upstream of that dam and intermediate farther upstream; patterns were similar in the reference stream. Although seasonal and annual variation in metrics within each site was substantial, the overall upstream‐to‐downstream pattern along the stream gradient was remarkably consistent prior to dam removal. Immediately after dam removal, we saw significant decreases in richness and abundance downstream of the former dam site and a corresponding increase in fish abundance upstream of the former dam site. No such changes occurred in reference sites. Our results show that by quantifying baseline conditions in a small stream before restoration, the effects of stream restoration efforts on fish assemblages can be monitored successfully. These data set the stage for the long‐term assessment of Sedgeunkedunk Stream and provide a simple methodology for assessment in other restoration projects. Copyright © 2011 John Wiley & Sons, Ltd.     

Chromosome studies in "preleukemia". III. Myelofibrosis

Cytogenetic studies were done on 18 patients with myelofibrosis or the closely related syndrome, undifferentiated myeloproliferative disorder (MPD). Clones of cells with chromosome abnormalities were demonstrated in the blood of eight individuals, including two with a history of radiation therapy and two with "acute myelofibrosis". Trisomy 8 was present in the latter two patients, but otherwise, there was no consistent cytogenetic pattern or correlation with specific hematologic findings. Sixteen of these patients have been followed for more than 1 year or until death; none has progressed to leukemia. The results indicate that chromosome abnormalities are relatively common in this disorder, but as with polycythemia vera, and unlike some other "preleukemic" states, the aberrant clones in myelofibrosis do not appear to indicate that clinical leukemia is imminent.     

A Clinical Trial to Test the Feasibility of a Telehealth Psychoeducational Intervention for Persons With Schizophrenia and Their Families: Intervention and 3-Month Findings.

Objective: To evaluate the feasibility of a telehealth psychoeducation intervention for persons with schizophrenia and their family members. Study Design: Randomized controlled trial. Participants: 30 persons with schizophrenia and 21 family members or other informal support persons. Interventions: Web-based psychoeducation program that provided online group therapy and education. Main Outcome Measures: Measures for persons with schizophrenia included perceived stress and perceived social support; for family members, they included disease-related distress and perceived social support. Results: At 3 months, participants with schizophrenia in the intervention group reported lower perceived stress (p = .04) and showed a trend for a higher perceived level of social support (p = .06). Conclusions: The findings demonstrate the feasibility and impact of providing telehealth-based psychosocial treatments, including online therapy groups, to persons with schizophrenia and their families. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Automatic Flow-Control Adaptation for Enhancing Network Performance in Computational Grids

With the advent of computational Grids, networking performance over the wide-area network (WAN) has become a critical component in the Grid infrastructure. Unfortunately, many high-performance Grid applications only use a small fraction of their available bandwidth because operating systems and their associated protocol stacks are still tuned for yesterday's WAN speeds. As a result, network gurus undertake the tedious process of manually tuning system buffers to allow TCP flow control to scale to today's WAN Grid environments. And although recent research has shown how to set the size of these system buffers automatically at connection set-up, the buffer sizes are only appropriate at the beginning of the connection's lifetime. To address these problems, we describe an automated and lightweight technique called dynamic right-sizing that can improve throughput by as much as an order of magnitude while still abiding by TCP semantics.     

Electrodiffusion Model Simulation of Ionic Channels: 1D Simulations

The drift-diffusion (Poisson-Nernst-Planck) model is applied to ionic channels in biological membranes plus surrounding solution baths. Simulations of the K channel in KCl solutions using the TRBDF2 method are presented which show significant boundary layers at the ends of the channel. The computed current-voltage curve for the K channel shows excellent agreement with experimental measurements.     

Student success prediction in MOOCs

Predictive models of student success in Massive Open Online Courses (MOOCs) are a critical component of effective content personalization and adaptive interventions. In this article we review the state of the art in predictive models of student success in MOOCs and present a categorization of MOOC research according to the predictors (features), prediction (outcomes), and underlying theoretical model. We critically survey work across each category, providing data on the raw data source, feature engineering, statistical model, evaluation method, prediction architecture, and other aspects of these experiments. Such a review is particularly useful given the rapid expansion of predictive modeling research in MOOCs since the emergence of major MOOC platforms in 2012. This survey reveals several key methodological gaps, which include extensive filtering of experimental subpopulations, ineffective student model evaluation, and the use of experimental data which would be unavailable for real-world student success prediction and intervention, which is the ultimate goal of such models. Finally, we highlight opportunities for future research, which include temporal modeling, research bridging predictive and explanatory student models, work which contributes to learning theory, and evaluating long-term learner success in MOOCs.     

Cinemetrics: Embodying architectural representation in the digital age

How can architecture emerge from the prison of its current forms of representation? Grahame Shane1 1 D.G. Shane, “Balkanization and the Postmodern City,” in Peter Lang (ed.), Mortal City, New York: Princeton Architectural Press, 1995, pp. 55-69. interprets the concluding diagram of Robin Evans' Projective Cast: Architecture and its Three Geometries2 2 Robin Evans, The Projective Cast: Architecture and Its Three Geometries, Cambridge, MA: MIT Press, 1995. as a critique of postmodern architecture's self-reflection and lack of engagement with the world. Shane argues that Evan's diagram depicts architectural representation as a self-reinforcing, closed, conceptual triangle of mirrored reflections between the human observer, the scopic regime of perspective, orthographic architectural drawing conventions, and designed objects. Shane draws his interpretation from Evans's early work on Victorian prison architecture as well as one of Evan's last public lectures. Shane characterized Evans' critical view of postmodern architectural practice and representation as a “self-correcting means of stabilization and pacification of the physical, built environment.”3 3 Shane, “Balkanization and the Postmodern City,” p. 68 This essay develops a theory of Cinemetrics that demonstrates how contemporary architectural production, with the aid of digital tools, has the capacity to break this closed system with open-ended, embodied cybernetic feed-back loops within a wider public culture engaged in the making and imagining of architecture.4 4 Brian McGrath and Jean Gardner, Cinemetrics: Architectural Drawing Today, London: Wiley-Academy, 2007. This essay argues that this break can only be accomplished by embodying architectural representation through a careful engagement with Gilles Deleuze's philosophy of movement and time images derived from cinema,5 5 Gilles Deleuze, Cinema 1: the movement image, Hugh Tomlinson and Habberjam (trans.), Minneapolis, MN: University of Minnesota, 1986; Cinema 2: the time-image, Hugh Tomlinson and Robert Galeta (trans.), Minneapolis, MN: University of Minnesota, 1989. Henri Bergson's theories of memory, attention and duration,6 6 Henri Bergson, Creative Evolution, Arthur Mitchell (trans.), Lanham, MD: University Press of America, 1991; Henri Bergson, Matter and Memory, M.N. Paul and W.S. Palmer (trans.), New York: Zone Books, 1991. and from Charles Sanders Peirce's pragmatic semiosis.7 7 Charles Sanders Peirce, The Essential Peirce: Selected Philosophical Writings, Vol. 2 (1893-1913), Peirce Edition Project, Bloomington, IN: Indiana University Press, 1998.      

Global instability of elliptical hollow section beam-columns under compression and biaxial bending

The global instability of elliptical hollow section members under combined compression plus biaxial bending is studied in this paper by means of laboratory testing and numerical simulations. A total of 9 beam-column tests were carried out under different combinations of compression and bending about both principal axes. The material properties of the tested sections were determined by means of tensile coupon tests. All tested elliptical hollow sections were EHS 150×75×5, and three nominal member lengths of 1 m, 2 m and 3 m were considered. Graphs of applied load versus mid-span bending moment, based on theoretical first and second order elastic considerations and the experimental second order inelastic response, are presented and described. Numerical models were initially validated against the experimental data using measured material and geometric properties, including imperfections. The models were subsequently employed in parametric studies to assess the influence of member slenderness and cross-sectional aspect ratio on the structural response. Finally, based on the experimental and numerical findings, design rules for hot-finished EHS beam-columns were assessed and statistically verified.     

Synthesis and Antiangiogenic Properties of Tetrafluorophthalimido and Tetrafluorobenzamido Barbituric Acids

The development of novel thalidomide derivatives as immunomodulatory and anti‐angiogenic agents has revived over the last two decades. Herein we report the design and synthesis of three chemotypes of barbituric acids derived from the thalidomide structure: phthalimido‐, tetrafluorophthalimido‐, and tetrafluorobenzamidobarbituric acids. The latter were obtained by a new tandem reaction, including a ring opening and a decarboxylation of the fluorine‐activated phthalamic acid intermediates. Thirty compounds of the three chemotypes were evaluated for their anti‐angiogenic properties in an ex vivo assay by measuring the decrease in microvessel outgrowth in rat aortic ring explants. Tetrafluorination of the phthalimide moiety in tetrafluorophthalimidobarbituric acids was essential, as all of the nonfluorinated counterparts lost anti‐angiogenic activity. An opening of the five‐membered ring and the accompanying increased conformational freedom, in case of the corresponding tetrafluorobenzamidobarbituric acids, was well tolerated. Their activity was retained, although their molecular structures differ in torsional flexibility and possible hydrogen‐bond networking, as revealed by comparative X‐ray crystallographic analyses.     

Polyamide 6–Cellulose Composites: Effect of Cellulose Composition on Melt Rheology and Crystallization Behavior

Melt rheology and crystallization behavior of polyamide 6 (PA 6) and microcrystalline cellulose (MCC) composites were systematically studied in this research. The incorporation of MCC into the PA 6 matrix resulted in higher complex viscosities (|η*|), storage modulus (G′), and shear viscosities than those of neat PA 6, especially at low frequencies. The orientation of rigid molecular chains in the composites introduced by the addition of MCC induced a strong shear thinning behavior with an increase in MCC loading. The non‐isothermal crystallization kinetics of PA 6 and MCC composites were investigated by differential scanning calorimetry. The Avrami and Tobin model were applied to describe the process of non‐isothermal crystallization and to determine the crystallization parameters of the composites. Analysis of the crystallization kinetics indicated that the Avrami (n_a) and Tobin exponent (n_t) was altered by the MCC. It was also found that the Avrami and Tobin equations fit the empirical data well. POLYM. ENG. SCI., 54:739–746, 2014. © 2013 Society of Plastics Engineers