Distribution-preserving statistical disclosure limitation

One approach to limiting disclosure risk in public-use microdata is to release multiply-imputed, partially synthetic data sets. These are data on actual respondents, but with confidential data replaced by multiply-imputed synthetic values. A mis-specified imputation model can invalidate inferences based on the partially synthetic data, because the imputation model determines the distribution of synthetic values. We present a practical method to generate synthetic values when the imputer has only limited information about the true data generating process. We combine a simple imputation model (such as regression) with density-based transformations that preserve the distribution of the confidential data, up to sampling error, on specified subdomains. We demonstrate through simulations and a large scale application that our approach preserves important statistical properties of the confidential data, including higher moments, with low disclosure risk.     

The effect of a lower extremity kinematic constraint on lifting biomechanics

Leaning against a stationary barrier during manual materials handling tasks is observed in many industrial environments, but the effects of this kinematic constraint on low back mechanics are unknown. Thirteen participants performed two-handed lifting tasks using both a leaning posture and no leaning posture while trunk kinematics, muscle activity and ground reaction force were monitored. Results revealed that lifting with the leaning posture required significantly less activity in erector spinae (26% vs. 36% MVC) and latissimus dorsi (8% vs. 14% MVC), and less passive tissue moment compared with the no leaning posture. Peak sagittal accelerations were lower when leaning, but the leaning posture also had significantly higher slip potential as measured by required coefficient of friction (0.05 vs. 0.36). The results suggested that the leaning lifting strategy provides reduced low back stress, but does so at the cost of increased slip potential.     

The impact of map orientation and generalisation on congestion decisions: a comparison of schematic-egocentric and topographic-allocentric maps

Map information for drivers is usually presented in an allocentric-topographic form (as with printed maps) or in an egocentric-schematic form (as with road signs). The advent of new variable message boards on UK motorways raises the possibility of presenting road maps to reflect congestion ahead. Should these maps be allocentric-topographic or egocentric-schematic? This was assessed in an eye tracking study, with participants viewing maps of a motorway network in order to identify whether any congestion was relevant to their intended route. The schematic-egocentric maps were responded to most accurately with shorter fixation durations suggesting easier processing. In particular, the driver's entrance and intended exit from the map were attended to more in the allocentric maps. Individual differences in mental rotation ability also seem to contribute to poor performance on allocentric maps. The results favour schematic-egocentric maps for roadside congestion information, but also provide theoretical insights into map-rotation and individual differences. Statement of Relevance: This study informs designers and policy makers about optimum representations of traffic congestion on roadside variable message signs and, furthermore, demonstrates that individual differences contribute to problems with processing certain sign types. Schematic-egocentric representations of a motorway network produced the best results, as noted in behavioural and eye movement measures.     

INTAMAP: The design and implementation of an interoperable automated interpolation web service

INTAMAP is a Web Processing Service for the automatic spatial interpolation of measured point data. Requirements were (i) using open standards for spatial data such as developed in the context of the Open Geospatial Consortium (OGC), (ii) using a suitable environment for statistical modelling and computation, and (iii) producing an integrated, open source solution. The system couples an open-source Web Processing Service (developed by 52°North), accepting data in the form of standardised XML documents (conforming to the OGC Observations and Measurements standard) with a computing back-end realised in the R statistical environment. The probability distribution of interpolation errors is encoded with UncertML, a markup language designed to encode uncertain data. Automatic interpolation needs to be useful for a wide range of applications and the algorithms have been designed to cope with anisotropy, extreme values, and data with known error distributions. Besides a fully automatic mode, the system can be used with different levels of user control over the interpolation process.     

Ergonomic interventions for commercial crab fishermen

Work tasks in the commercial fishing industry require strength, endurance and coordination and these tasks expose fishermen to many of the recognized risk factors for the development of work-related musculoskeletal disorders. The focus of the current study was the design, development and testing of two simple ergonomic interventions to reduce exposure to these risk factors in small-scale commercial crab fishermen. In a laboratory study of these interventions, EMG and motion analysis systems were used to quantify changes in muscle force and body postures. The results of laboratory evaluation of the intervention designed to reduce the low back stress associated with hoisting the crab pots onboard showed significant reductions in muscle force requirements (erector spinae activity reduced by 25%) and peak sagittal trunk angle (reduced by 34%), while the results of the intervention designed to reduce shoulder stress during the process of shaking the crabs from the pots showed significant reductions in peak deltoid activity (reduced by 24%). A field test of these interventions provided a more subjective “usability” evaluation of the interventions. These responses were cautiously positive, providing insights into when these interventions would be most appropriate and under what conditions they would be more of a hindrance than a help.

Relevance to industry

Engineering controls are recognized as the most effective methods of reducing exposure to risk factors for musculoskeletal injury. Engineering controls were developed for small-scale commercial crab fishermen and these interventions were tested in the laboratory and in the field.     

Automated High Throughput Screening of Fluorescent Imaging Plate Reader (FLIPR) Assays Using Assay Platform™ Integrated with Activity Base for ‘on the fly’ Compound Reconfirmation

Advances in the field of automation have meant hitherto complex manual cell-based assays can now be automated. These improvements have brought significant enhancements in throughput, data fidelity and consistency, and allowed a reallocation of constrained resources.Building upon these improvements, we have linked our automated cell-based screening system, Assay Platform™, to Activity Base (IDBS), a software package designed to automate the analysis of HTS data. Customisation of this package has resulted in software that can identify ‘active’ compounds and re-pick them ‘on the fly’ from the original compound plates for triplicate re-testing without operator intervention.Based on an operator initially defining ‘normal’ parameters for assay activity in Activity Base, combined with an automated quality control software module that checks data fidelity, wells containing ‘active’ compounds can be re-picked and re-tested at the end of an automated screening run. Automating cell-based assays has significantly improved productivity, and, with the synergism of Activity Base, has given us greater power to complete each screening run and report ‘active’ compounds to Chemistry more rapidly. This article presents our approach to the automation of cell-based Fluorescent Imaging Plate Reader (FLIPR) screening together with automated active re-test confirmation using Activity Base.     

Silver Bullet Talks with Ed Amoroso

Gary McGraw interviews Ed Amoroso, AT&T's chief information security officer. Their conversation ranged widely, from system design to privacy.     

Top-down proteomic analysis by MALDI-TOF profiling: Concentration-independent biomarkers

Although numerous protein biomarkers have been correlated with advanced disease states, no new clinical assays have been developed. Goals often anticipate disease-specific protein changes that exceed values among healthy individuals, a property common to acute phase reactants. This review considers somewhat different approaches. It focuses on intact protein isoform ratios that present a biomarker without change in the total concentration of the protein. These will seldom be detected by peptide level analysis or by most antibody-based assays. For example, application of an inexpensive method to large sample groups resulted in observation of several polymorphisms, including the first structural polymorphism of apolipoprotein C1. Isoform distribution of this protein was altered and was eventually linked to increased obesity. Numerous other protein isoforms included C- and N-terminal proteolysis, changes of glycoisoform ratios and certain types of sulfhydryl oxidation. While many of these gave excellent statistical correlation with advanced disease, clinical utility was not apparent. More important may be that protein isoform ratios were very stable in each individual. Diagnosis by longitudinal analysis of the same individual might increase sensitivity of protein biomarkers by 20-fold or more. Protein changes that exceed the range of values found among healthy individuals may be uncommon.     

An evaluation of backpack harness systems in non-neutral torso postures

Much of the research on backpack design has been focused on spinal loading/biomechanics while the wearer is in a neutral/upright trunk posture, such as those employed by outdoor enthusiasts and schoolchildren. This research has led to some important harness design improvements that reduce trunk muscle exertions, fatigue and improve overall comfort. There are number of occupations, however, wherein workers wear back-mounted packs/devices (e.g. air tanks) while working in non-neutral trunk postures. The objective of the current study was to evaluate the effects of these non-neutral postures on biomechanical loading and then reconsider the backpack system design recommendations. Fifteen participants were asked to support a 18.2 kg load on their back while assuming static forward flexed postures of the torso (15 degrees , 30 degrees , 45 degrees , and 60 degrees of sagittal bend). The mass on the back was attached to the participant through two different harness mechanisms: a basic harness design (as seen on college student backpacks) and a more advanced design containing lateral stiffness rods and a weight-bearing hip belt (as seen on backpacks for hikers). While performing these static, posture maintenance tasks, the activation levels of the bilateral trapezius, erector spinae, and rectus abdominis were collected. Participants also provided subjective ratings of comfort. The results showed that there was a significant interaction between harness type and forward flexion angle for the trapezius and the erector spinae muscles. The normalized EMG for the trapezius muscles showed a 14% and 11% reduction in muscle activity at 15 degrees and 30 degrees , respectively, with the advanced design but these positive effects of the advanced design were not found at the greater flexion angles. Likewise the erector spinae muscles showed a 24% and 14% reduction in muscle activity at 15 degrees and 30 degrees , respectively, with the advanced design harness but these effects of the advanced design were not found at the greater forward flexion angles. The level of forward flexion angle affected the rectus abdominis muscle activity, but neither the harness type main effect nor the interaction of harness type and forward flexion angle was significant. The subjective survey results agreed with the EMG results and showed the advanced design harness was generally more comfortable with respect to the shoulder and low back areas. Collectively, the subjective and objective results show a significant improvement with the advanced harness system but also note an interesting interaction with degree of sagittal flexion, indicating a diminished effectiveness of the design improvements at forward flexed postures. Design criteria for harness systems in these forward flexed postures are discussed.