Operationalizing sustainability in urban coastal systems: A system dynamics analysis

We propose a system dynamics approach for Ecologically Sustainable Development (ESD) in urban coastal systems. A systematic analysis based on theoretical considerations, policy analysis and experts' knowledge is followed in order to define the concept of ESD. The principles underlying ESD feed the development of a System Dynamics Model (SDM) that connects the pollutant loads produced by urban systems' socioeconomic activities with the ecological condition of the coastal ecosystem that it is delineated in operational terms through key biological elements defined by the EU Water Framework Directive. The receiving waters of the Athens Metropolitan area, which bears the elements of typical high population density Mediterranean coastal city but which currently has also new dynamics induced by the ongoing financial crisis, are used as an experimental system for testing a system dynamics approach to apply the concept of ESD. Systems' thinking is employed to represent the complex relationships among the components of the system. Interconnections and dependencies that determine the potentials for achieving ESD are revealed. The proposed system dynamics analysis can facilitate decision makers to define paths of development that comply with the principles of ESD.     

Understanding differences in construction project governance between developed and developing countries

Whereas most experts recognize the substantial differences in the construction sector between developed and developing countries, very little is known about how and to what extent construction project governance actually differs between the two contexts. In order to shed light on these differences, a suitable definition of project governance must be adopted and identical variables must be assessed in developed and developing contexts. Three characteristics of temporary multi-organizations that conduct construction projects (used here as categories of analysis) help identify these differences: formal structuring, informal structuring, and the role and participation of stakeholders. Based on three case studies, a survey, and semi-directed interviews, significant differences are found in how power and authority are exercised (and leadership styles applied), in the use of informality and in the roles assumed by stakeholders. Although the analysis of such differences is often considered a diagnosis of problems to be ‘fixed’ in projects in developing countries, we believe that these differences should be read as project governance mechanisms of adaptation to different environmental conditions, and therefore key elements that need to be fully understood by professionals working in developing countries.     

Resource provision ego-networks in small Greek construction firms

The prominence of small professional service providers in a fragmented construction sector in part relates to the ability to provide competitive advantage through the provision of a personalized service in a context where diseconomies of scale prevail. The Greek construction industry is particularly representative of this trend towards the dominance of small businesses. The small business owner relies upon their ability to secure critical resources through personal networks which provide information, advice, funding and brokerage. Resource provision ego-networks are investigated structurally using social network analysis. A multiple case study approach is employed with comparative social network analysis, focusing on the density of ego-networks and the prominence of resource providers and associated subgroups. Findings show that commercial development activity is promoted through high-density networks, which infers that higher levels of connectivity characterize networks operating in environments of uncertainty. As these critical resource networks mature, they appear to rely less on strong ties and temporary formal project networks. Contractual relationships appear to co-exist with reciprocal flows of resources outside the contract's scope.

L'importance des petits prestataires de services professionnels dans un secteur du bâtiment qui est fragmenté tient pour partie à la capacité à assurer un avantage concurrentiel par la fourniture d'un service personnalisé dans un contexte où les déséconomies d'échelle prévalent. L'industrie grecque du bâtiment est particulièrement représentative de cette tendance à la dominance des petites entreprises. Le propriétaire d'une petite entreprise s'appuie sur sa capacité à garantir des ressources critiques par des réseaux personnels qui fournissent des informations, des conseils, du financement et des services de courtage. Les ego-réseaux prestataires de ressources sont examinés d'un point de vue structurel en utilisant une analyse des réseaux sociaux. Il est employé une approche basée sur une étude de cas multiples s'accompagnant d'une analyse comparative des réseaux sociaux, centrée sur la densité des ego-réseaux et sur l'importance des prestataires de ressources et des sous-groupes associés. Les résultats constatés montrent que la promotion des activités de développement commercial se fait par les réseaux haute densité, ce qui induit que des niveaux supérieurs de connectivité caractérisent les réseaux fonctionnant dans des contextes marqués par l'incertitude. Au fur et à mesure que ces réseaux de ressources critiques mûrissent, ils semblent moins s'appuyer sur des liens forts et des réseaux temporaires en rapport avec des projets formels. Il apparaît que les relations contractuelles coexistent avec des flux de ressources réciproques en dehors du champ du contrat.

ego-réseaux ou réseaux personnels, activité entrepreneuriale, réseaux prestataires de ressources, PME du bâtiment, analyse des réseaux sociaux     

Novel quantification of coupled natural and cross-sectoral water and nutrient/pollutant flows for environmental management

Human water use and anthropogenic water pollution and ecosystem deterioration have increased so much that it is now a strategic challenge to maximize benefits from various possible water uses, while ensuring that basic human needs are met and the environment is protected. We propose and develop a novel use of input-output flow analysis as a relatively simple, compact and powerful tool for quantification of coupled natural and cross-sectoral flows of water, nutrients, and pollutants in catchments. The tool quantifies implications of various environmental regulation and management scenarios for both natural water systems and engineered-economic systems and sectors that use and impact natural waters for meeting human needs. Specific case study application to water and nitrogen flows in the Swedish Norrstr?m drainage basin indicates considerable nitrogen load contributions to surface and coastal waters from slow groundwater flow paths and legacies of accumulated nitrogen in subsurface and immobile water pools. This implies that effective nitrogen load abatement cannot focus only on active sources but must also include downstream measures, which can capture and abate nitrogen/pollutant loading from different types of known and yet unknown point and diffuse sources within associated catchments.     

The Role of Interleukins in Recurrent Implantation Failure: A Comprehensive Review of the Literature

Recurrent implantation failure (RIF) is a multifactorial condition affecting 10–15% of in vitro fertilization (IVF) couples. Data suggest that functional dysregulation of the endometrial immune system constitutes one of the main pathophysiological mechanisms leading to RIF. The aim of this article is to provide a thorough presentation and evaluation of the role of interleukins (ILs) in the pathogenesis of RIF. A comprehensive literature screening was performed summarizing current evidence. During implantation, several classes of ILs are secreted by epithelial and stromal endometrial cells, including IL-6, IL-10, IL-12, IL-15, IL-18, and the leukemia inhibitory factor. These ILs create a perplexing network that orchestrates both proliferation and maturation of uterine natural killer cells, controls the function of regulatory T and B cells inhibiting the secretion of antifetal antibodies, and supports trophoblast invasion and decidua formation. The existing data indicate associations between ILs and RIF. The extensive analysis performed herein concludes that the dysregulation of the ILs network indeed jeopardizes implantation leading to RIF. This review further proposes a mapping of future research on how to move forward from mere associations to robust molecular data that will allow an accurate profiling of ILs in turn enabling evidence-based consultancy and decision making when addressing RIF patients.     

Unveiling the Essential Role of Arkadia’s Non-RING Elements in the Ubiquitination Process

Arkadia is a positive regulator of the TGFβ-SMAD2/3 pathway, acting through its C-terminal RING-H2 domain and targeting for degradation of its negative regulators. Here we explore the role of regions outside the RING domain (non-RING elements) of Arkadia on the E2-E3 interaction. The contribution of the non-RING elements was addressed using Arkadia RING 68 aa and Arkadia 119 aa polypeptides. The highly conserved NRGA (asparagine-arginine-glycine-alanine) and TIER (threonine-isoleucine-glutamine-arginine) motifs within the 119 aa Arkadia polypeptide, have been shown to be required for pSMAD2/3 substrate recognition and ubiquitination in vivo. However, the role of the NRGA and TIER motifs in the enzymatic activity of Arkadia has not been addressed. Here, nuclear magnetic resonance interaction studies with the E2 enzyme, UBCH5B, C85S UBCH5B-Ub oxyester hydrolysis, and auto-ubiquitination assays were used to address the role of the non-RING elements in E2-E3 interaction and in the enzymatic activity of the RING. The results support that the non-RING elements including the NRGA and TIER motifs are required for E2-E3 recognition and interaction and for efficient auto-ubiquitination. Furthermore, while Arkadia isoform-2 and its close homologue Arkadia 2C are known to interact with free ubiquitin, the results here showed that Arkadia isoform-1 does not interact with free ubiquitin.     

Secondary V(D)J recombination in B-1 cells

B-1 B cells are a self-renewing population of B cells that differ from conventional B cells (B-2 cells) in that they are particularly predisposed to auto-antibody production. Although much is known about the signalling pathways that control B-1-cell growth and development, less is known about why these cells are prone to produce autoreactive antibodies. Here we show that B-1 cells, like germinal-centre B cells, can express recombinase-activating genes 1 and 2 (RAG1 and RAG2) and undergo secondary V(D)J recombination of immunoglobulin genes. In addition, B cells from autoimmune-prone NZB mice show high levels of RAG messenger RNA and recombination. We propose that secondary immunoglobulin-gene rearrangements outside organized lymphoid organs may contribute to the development of autoreactive antibodies.