Retinal neurostimulator for a multifocal vision prosthesis.

A neurostimulator application-specific integrated circuit (ASIC) with scalable circuitry that can stimulate 14 channels, has been developed for an epi-retinal vision prosthesis. This ASIC was designed to allow seven identical units to be connected to control up to 98 channels, with the ability to stimulate 14 electrodes simultaneously. The neurostimulator forms part of a vision prosthesis, designed to restore vision to patients who have lost their sight due to retinal diseases such as retinitis pigmentosa and macular degeneration. For charge balance, the neurostimulator was designed to stimulate with current sources and sinks operating together, and with the ability to drive a hexagonal mosaic of electrodes to reduce the electrical crosstalk that occurs when multiple bipolar stimulation sites are active simultaneously. A hexagonal mosaic of electrodes surrounds each stimulation site and has been shown to effectively isolate each site, increasing the ability to inject localized independent charge into multiple regions simultaneously.     

Synthesis of Aminopyridazines from Aminocyclopropenylium Salts and Diazomethyl Compounds [1]

Amino-substituted cyclopropenylium salts ( 11a,b ) react with diazomethyl compounds ( 12a-i ) in dichloromethane or acetonitrile in the presence of a base (ethyldiisopropylamine, 1,5-diazabicyclo[4.3.0] non-5-ene) to form 4-aminopyridazines ( 13a-i ) specifically. The reaction is interpreted in terms of an initial electrophilic diazoalkane substitution to give diazomethylcyclopropenes ( 11 + 12 → 14 ) which undergo a [1.5]-cyclisation to form the betaines 16 which, in turn, isomerise with opening of the bridging bond to give the aminopyridazines 13 . In a similar manner, the tris[amino] cyclopropenylium salts 8a,b and 10a-c are converted to the 3,4,5-tris[amino]-pyridazines ( 21a-k ) by treatment with diazomethyl compounds ( 12a, c-f ).     

On-chip high voltage charge pump in standard low voltage CMOS process

An on-chip high voltage tolerant 4VDD charge pump with symmetrical architecture in a standard low voltage 1.8 V 0.18 /spl mu/m CMOS process is presented. For a 250 k/spl Omega/ load, circuit efficiency of the charge pump is approximately 71%. All the MOS transistors satisfy typical voltage stress related reliability requirements for standard low voltage CMOS devices.     

Multiple access for UWB impulse radio with pseudochaotic time hopping

Pseudochaotic time hopping (PCTH) is a previously proposed encoding/modulation scheme for ultra-wideband (UWB) impulse radio. PCTH exploits concepts from symbolic dynamics to generate aperiodic spreading sequences, resulting in a noise-like spectrum. We present a multiple-access technique suitable for the PCTH scheme. In particular, we provide an analytical expression of the bit-error rate performance as a function of the number of users and validate it by simulation.