Efficient Techniques for Attack Detection Using Different Features Selection Algorithms and Classifiers

Wireless Personal Communications - With the growth and benefits of network usage, securing the networks by using anomaly intrusion detection systems (IDS) against unknown intrusions has become an...     

Effect of carbon backbone on luminescence properties of Eu-organic hybrid thin films prepared by ALD/MLD

Journal of Materials Science - Here we show that the backbone of the organic ligand has a profound impact on the luminescence characteristics of lanthanide-organic materials. We employ the emerging...     

Design,Synthesis and Biological Characterization of Histone Deacetylase 8 (HDAC8) Proteolysis Targeting Chimeras (PROTACs) with Anti-Neuroblastoma Activity

In addition to involvement in epigenetic gene regulation, histone deacetylases (HDACs) regulate multiple cellular processes through mediating the activity of non-histone protein substrates. The knockdown of HDAC8 isozyme is associated with the inhibition of cell proliferation and apoptosis enhancement in several cancer cell lines. As shown in several studies, HDAC8 can be considered a potential target in the treatment of cancer forms such as childhood neuroblastoma. The present work describes the development of proteolysis targeting chimeras (PROTACs) of HDAC8 based on substituted benzhydroxamic acids previously reported as potent and selective HDAC8 inhibitors. Within this study, we investigated the HDAC8-degrading profiles of the synthesized PROTACs and their effect on the proliferation of neuroblastoma cells. The combination of in vitro screening and cellular testing demonstrated selective HDAC8 PROTACs that show anti-neuroblastoma activity in cells.     

Block-based SVD image watermarking in spatial and transform domains

The idea of this paper is to implement an efficient block-by-block singular value (SV) decomposition digital image watermarking algorithm, which is implemented in both the spatial and transforms domains. The discrete wavelet transform (DWT), the discrete cosine transform and the discrete Fourier transform are exploited for this purpose. The original image or one of its transforms is segmented into non-overlapping blocks, and consequently the image to be inserted as a watermark is embedded in the SVs of these blocks. Embedding the watermark on a block-by-block manner ensures security and robustness to attacks such like Gaussian noise, cropping and compression. The proposed algorithm can also be used for colour image watermarking. A comparison study between the proposed block-based watermarking algorithm and the method of Liu is performed for watermarking in all domains. Simulation results ensure that the proposed algorithm is more effective than the traditional method of Liu, especially when the watermarking is performed in the DWT domain.     

Surface Properties and Biological Activity of Select Cationic Surfactants

A series of cationic surfactants, N-(decyl N-tri-ethanol ammonium Bromide) (C₁₀), N-(dodecyl N-triethanol ammonium Bromide) (C₁₂), N-(hexadecyl N-triethanol ammonium Bromide) (C₁₆) were synthesized. These compounds have been evaluated by studying their surface properties, surface parameters, biodegradability and antimicrobial and antifungal activities.

Moisture sorption by modified-activated carbons

Modified activated carbons were prepared by the partial oxidation of activated maghara coal with concentrated nitric acid and potassium permanganate. This treatment fixes more oxygen on the carbon surface leading thus to the formation of carbon-oxygen complexes which act as primary centers for water adsorption. Not only the number of oxygen complexes that can determine the water adsorption properties but the pore size may be considered as another factor. The oxygen complexes outgassed as carbon dioxide can be qualitatively determined by neutralization with sodium hydroxide. These oxygen complexes are responsible for the irreversibly adsorbed water.     

Phase separation of binary blends in polymer nanoparticles

Polymer blends in nanoparticles have been studied by transmission electron microscopy (TEM) and photoluminescence (PL) spectroscopy. The TEM studies show that blend particles formed from two immiscible polymers by the miniemulsion process exhibit biphasic morphologies. The fact that no core-shell type but Janus-like structures were found indicates that the surface free energies between both polymers and the solution-water interface (including the surfactant molecules) are similar; therefore, the blend morphology and composition of the individual phases are mainly determined by the interaction between the two polymer components. Both the TEM studies and the PL experiments provide strong evidence that phase separation in these particles strictly follows the Flory-Huggins theory. This highlights the applicability of the nanoparticle approach to fabricate blend systems with well-controllable properties and to study structure-property relationships under well-defined conditions.