喷射成形高温合金沉积态组织的形成与演变

对喷射成形高温合金的组织形成及其从雾化过程的树枝晶向等轴晶组织的演变过程进行了分析，结果表明，半液态层中发生的枝晶破碎，重熔所造成的核心增殖作用为等轴晶组织的形成提供了大量结晶核心，在此基础上枝晶臂的合并，粗化以及未严重固相枝晶的粗化和均匀化产生了喷射成形材料所持有的非枝非等轴晶组织。     

Reactivity study and kinetic evaluation of CuO-based oxygen carriers modified by three different ores in chemical looping with oxygen uncoupling (CLOU) process

In the chemical looping with oxygen uncoupling (CLOU) process,CuO is a promising material due to the high oxygen carrier capacity and exothermic reaction in fuel reactor but limited by the low melting point.The combustion rate of carbon is faster than the decoupling rate of oxygen carrier (OC).Hence,high tem-perature tolerance and rapid oxygen release rate of CuO modified by three different ores were investi-gated in this study.The kinetics analysis of oxygen decoupling with Cu-based oxygen carriers was also evaluated.Results showed that CuO modified by chrysolite had faster oxygen release rate than that of CuO.Limestone showed obvious positive effect on the oxidization process.The selected OCs could keep stable in at least 20 cycles,for about 1200 min.Shrinking core model (SCM) fitted well for the decoupling process in the temperature range of 1123-1223 K.Reduction rate kinetic information may aid in the development of chemical looping with oxygen uncoupling (CLOU) technologies during reactor design and process modeling.Ternary doped copper oxide with chrysolite and limestone could improve the reactivity of CuO in decoupling and coupling process and also improve the high temperature tolerance.     

The miR-106b/NR2F2-AS1/PLEKHO2 Axis Regulates Migration and Invasion of Colorectal Cancer through the MAPK Pathway

Increasing numbers of miRNAs have been observed as oncogenes or tumor suppressors in colorectal cancer (CRC). It was recently reported that hsa-miR-106b-5p (miR-106b) promoted CRC cell migration and invasion. However, there were also studies showing contradictory results. Therefore, in the present study, we further explore the role of miR-106b and its downstream networks in the carcinogenesis of CRC. We observed that the expression of miR-106b is significantly increased in Pan-Cancer and CRC tissues compared with normal tissues from The Cancer Genome Atlas (TCGA) database. Furthermore, we used Transwell, Cell Counting Kit-8, and colony formation assays to clarify that miR-106b promotes the migratory, invasive, and proliferative abilities of CRC cells. For the first time, we systematically screened the target mRNAs and lncRNAs of miR-106b using TCGA database and the bioinformatics algorithms. Dual-luciferase reporter assay confirmed that NR2F2-AS1 and PLEKHO2 are the direct targets of miR-106b. Furthermore, NR2F2-AS1 acts as a competing endogenous RNA (ceRNA) to regulate PLEKHO2 expression by sponging miR-106b. The results of Gene set enrichment analysis (GSEA) and Western blot indicated that they play important roles in CRC progression by regulating MAPK pathway. Thus, miR-106b/NR2F2-AS1/PLEKHO2/MAPK signaling axis may suggest the potential usage in CRC treatment.     

Toward Largely Enhanced Toughness and Balanced Strength in PA1012/EPDM Blends via Synergistic Effect of Sacrificial Bonds and Network Structure

Here, zinc-neutralized ethylene propylene diene monomer (EPDM) ionomers with different neutralization levels are prepared through melt blending, and are then incorporated with polyamide 1012 (PA1012) to fabricate PA1012/EPDM ionomer blends. Interestingly, complex crosslinking networks are formed in the blends due to the construction of sacrificial bonds (Zn²⁺-carboxyl, Zn²⁺-amide). The as-formed network structure and sacrificial bond endow the PA/EPDM blends with largely enhanced toughness (16 times higher than that of neat PA), as well as balanced strength and stiffness. Meanwhile, the rheological behaviors of PA1012/EPDM ionomer blends indicate their relative low melting viscosity, which can avoid the processing shortcomings of plastics toughened with rubber. Moreover, PA1012/EPDM ionomer blends show obvious gelation behavior, and a maximum notched Izod impact strength exhibited at the gel point, in which unique double network structure can be observed obviously, indicating that there is a corresponding correlation between the rheological and mechanical parameters. Furthermore, the supper-toughening mechanism of PA1012/EPDM ionomer blends at gel point is explored, which origins from the large deformation and cavitation of rubber particles and the destruction of special double network morphologies. This study provides a novel and effective strategy to fabricate PA materials with outstanding toughness and excellent strength simultaneously.     

A “Three-in-One” Multifunctional Probe for Bcl-2/Mcl-1 Profiling and Visualizing in Situ

Bcl-2 and Mcl-1, the two arms of the anti-apoptotic Bcl-2 family proteins, have been identified as key regulators of apoptosis and effective therapeutic targets of cancer. However, no small-molecular probe is capable of profiling and visualizing both Bcl-2 and Mcl-1 simultaneously in situ. Herein, we report a multifunctional molecular probe (BnN₃-OPD-Alk) by a “three-in-one” molecular designing strategy, which integrated the Bcl-2/Mcl-1 binding ligand, fluorescent reporter group and photoreactive group azido into the same scaffold. BnN₃-OPD-Alk exhibited sub-micromolar affinities to Bcl-2/Mcl-1 and bright green self-fluorescence. It was then successfully applied for Bcl-2/Mcl-1 labeling, capturing, enriching, and bioimaging both in vitro and in cells. This strategy could facilitate the precise early diagnosis and effective therapy of dual Bcl-2/Mcl-1-related diseases.     

钨尾矿微晶玻璃的形状记忆效应

研究了钨尾矿微晶玻璃的形状记忆效应（ＳＭＥ），并用Ｘ射线衍射法（ＸＲＤ）作了相分析。结果表明，钨尾矿微晶玻璃具有明显的ＳＭＥ；恢复应变随回复保温温度升高而增加；该材料随着变形量的减小，形状恢复率随之上升     

STUDY OF MECHANISM OF RQ EMBRITTLEMENT OF Fe_(73.5)Cu_1-Nb_3Si_(13.5)B_9 NANOCRYSTALLINE SOFT MAGNETIC ALLOY

Rapidly quenching embrittlement (RQE) sometimes appears in Fe73.5Cu1Nb3Si13.5B9 nanocrystalline soft magnetic alloy (FINEMET) during production process. As a re-sult of RQE the ductility of the as-quenched ribbon drops seriously. The mechanism of RQE has been elucidated in the recent works of current authors. It was believed that RQE is due to the structural relaxation but not related to a-Fe(Si) crystallization. In this paper, the high resolution TEM (HRTEM) method and image digital processing were applied to analyze the HRTEM images of two FINEMET rapidly quenched ribbons with different thicknesses in detail. In the thinner ductile sample, the ordering domains with the size of about 3nm are observed. In the thicker RQE sample, the metastable nanocrystalline domains with the size of 18nm are observed along with the structural relaxation. These domains seem to have Fe3B-like metastable phase struc-ture on nanometer scale. The result indicates that the local atomic ordering regions extend when RQE induced     

A NEW CHELATING EXTRACTANT H 106

本文介绍了异羟肟酸型螯合萃取剂 H106的稳定性及其在金属萃取中的行为,研究了用 H106进行金属萃取的机理和萃合物的稳定常数.实验结果表明,H106的稳定性很高,对金属的萃取性能很好.H106是一种一元弱酸,在试验条件下,它通过氧-氧配位,与金属离子形成内络盐 MeL_n.其对各金属离子的萃取能力强弱与金属络合物积累稳定常数的大小顺序相一致.在一定条件下,在萃取中表现出极佳的选择性.用 H106由湿法炼锌厂置换渣的硫酸浸出液中回收 Ga 和 Ge 已获得十分满意的结果.也可以用于微量钛测定和其他许多方面.     

仿真转台用新型连续回转电液伺服马达研究

本文介绍了一种新型仿真转台用叶片式无脉动连续回转电液伺服马达的工作原理，并提出为验证马达性能的非线性PI和微分前馈的复合控制策略，并通过试验对马达的性能进行了验证。     

中国有色金属再生资源回收利用及展望

一、有色金属再生资源利用现状我国是有色金属资源短缺的国家，节约和合理使用资源显得特别重要。世界上工业发达国家对再生资源利用相当重视。近10年来世界再生铜产量已占原生铜产量的40％～55％，美国约占本国原生铜产量的60％，日本约占45％，德国约占80％。世界再生铝产量也占原生铝产量的30％～50％，美国约占本国原生铝的50％，日本约占90％，德国约占45％。世界再生铅产量也占原生铅产量的40％～60％，美国约占本国原生铅的75％，日本约占60％，德国约占55％。锌、镍、镁、锡、锑等再生资源也得到不同程度的利用。