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Alessio Bottrighi Gianpaolo Molino Stefania Montani Paolo Terenziani Mauro Torchio 《Computer methods and programs in biomedicine》2013
Clinical guidelines (GL) play an important role in medical practice: the one of optimizing the quality of patient care on the basis of evidence based medicine. In order to achieve this goal, the interaction between different agents, who cooperate in the execution of the same GL, is a crucial issue. As a matter of fact, in many cases (e.g. in chronic disorders) the GL execution requires that patient treatment is not performed/completed in the hospital, but is continued in different contexts (e.g. at home, or in the general practitioner's ambulatory), under the responsibility of different agents. In this situation, the correct interaction and communication between the agents themselves is critical for the quality of care, and human resources coordination is a key issue to be addressed by the managers of the involved healthcare services. In this paper we describe how GLARE (Guideline Acquisition, Representation, and Execution), a computerized GL management system, has been extended in order to support such a need. In particular, we have provided: (i) an extension to GL actions representation languages, (ii) proper scheduling and (iii) querying services. By means of these enhancements we aimed at guaranteeing (1) treatment continuity and (2) responsibility assignment support in the various steps of a coordinated and distributed patient care process. We illustrate our approach by means of a practical case study. 相似文献
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Lucia Morrone Enrico Vagnoni Nicola Di Virgilio Luisa Neri Francesca Rapparini Gianpaolo Bertazza Pierpaolo Duce Annalisa Rotondi 《Journal of the American Oil Chemists' Society》2020,97(10):1119-1129
In a 3-year study, the chemical compositions of extra virgin olive oils (EVOO) of Bosana variety deriving from three different growing areas in Northern Sardinia were characterized, together with the pedo-climatic conditions of the three different growing areas, to gauge any differences at the chemical level. The main chemical differences in the oils from the three-studied areas were recorded in the fatty acid profiles [palmitic, oleic, and linoleic acid; sum of saturated (SFA), monounsaturated (MUFA), and polyunsaturated (PUFA) fatty acids]: these dissimilarities were ascribable to the environmental characteristics of the Alghero area, while others analytical parameters such as tocopherols, pigments, phenolic, and volatile compounds were not affected by production area. Fatty acids profile revealed a clear relation with temperature at a mesoclimate level, allowing a clusterization of the production areas. Our study provided evidences that pedo-climatic factors affect the quality of EVOO; in particular, in the case of Bosana cultivar the acidic fraction resulted one of the main traits differentiating the olive growing areas. 相似文献
34.
Monica Anese Maria Valeria De Bonis Giorgio Mirolo Gianpaolo Ruocco 《Journal of food engineering》2013
Ultrasound induced changes of certain physical and chemical properties of molecules are nowadays exploited at industrial level for food processing and preservation purposes. Deeper knowledge on the mechanisms influencing these changes would contribute to extend implementations of ultrasound to steer structure and functionality of food molecules. 相似文献
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Gianpaolo Andrich Ugo Nesti Francesca Venturi Angela Zinnai Roberto Fiorentini 《European Journal of Lipid Science and Technology》2005,107(6):381-386
Marine microalgae are recognised as an important renewable source of bioactive lipids with a high proportion of polyunsaturated fatty acids (PUFA), which have been shown to be effective in preventing or treating several diseases. For the extraction of oil from microalgae, supercritical CO2 (ScCO2) is regarded with interest, being safer than hexane and offering a negligible environmental impact, a short extraction time and a high‐quality final product. Whilst some experimental papers are available on the supercritical fluid extraction (SFE) of oil from microalgae, only limited information exists on the kinetics of the process. In such a contest, a mathematical model able to describe the kinetics of the SFE was applied to the recovery with ScCO2 of lipids from Nannochloropsis sp., a marine microalga commonly used in aquaculture and characterised by a lipid fraction with a high PUFA content. The aim of this paper was to examine the effect of operating conditions on the kinetics of the SFE, on process yields and on the fatty acid composition of lipid extracts. 相似文献
38.
The constantly increasing market requirements of high quality vehicles ask for the automotive manufacturers to carry out—before starting mass production—reliability demonstration tests on new products. However, due to cost and time limitation, a small number of copies of the new product are available for testing, so that, when the classical approach is used, a very low level of confidence in reliability estimation results in. In this paper, a Bayes procedure is proposed for making inference on the reliability of a new upgraded version of a mechanical component, by using both failure data relative to a previous version of the component and prior information on the effectiveness of design modifications introduced in the new version. The proposed procedure is then applied to a case study and its feasibility in supporting reliability estimation is illustrated. 相似文献
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Farrell L Verdonck P Van Besien E Ciofi I Borrello G Vanstreels K Mardani S Baklanov MR 《Journal of nanoscience and nanotechnology》2011,11(9):8363-8367
Nanoporous low-kappa films were manufactured by using a 3-step process: co-deposition of a skeleton and porogens by PECVD, porogen removal by remote plasma and UV cure. In this study, the influence of both the variation of the porogen load and the different types of UV-cures on several film characteristics were investigated. Improved kappa-values were observed for increased porogen to skeleton ratios and a broad band cure, where the wavelength of the photons is always higher than 200 nm. However the Young's modulus and hardness decreased correspondingly. These variations can be attributed to the changing density and chemical composition of the different films. A wide range of low-kappa films was obtained by tuning the porogen load and applying different types of UV cures. 相似文献
40.
Vione D Falletti G Maurino V Minero C Pelizzetti E Malandrino M Ajassa R Olariu RI Arsene C 《Environmental science & technology》2006,40(12):3775-3781
Hydroxyl radical formation rates, steady-state concentration, and overall scavenging rate constant were measured by irradiation of surface lake water samples from Piedmont (NW Italy) and nitrate-rich groundwater samples from Moldova (NE Romania). Dissolved organic matter (DOM) was the main source and sink of *OH upon lake water irradiation, with [*OH] being independent of DOM amount. Water oxidation by photoexcited DOM is a likely *OH source in the presence of very low levels of nitrate and dissolved iron. Under different circumstances it is not possible to exclude other processes, e.g., DOM-enhanced photo-Fenton reactions. Under the hypotheses of no interaction and absence of mutual screening of radiation, nitrate would prevail over DOM as *OH source for a NO3-/DOM ratio higher than 3.3 x 10(-5) (mol NO3-) (mg C)(-1), DOM prevailing for lower values. Substantial DOM photolability was observed upon irradiation of nitrate-rich groundwater, mainly due to the elevated *OH generation rate. For the first time to our knowledge, evidence was also obtained of the photoformation of potentially toxic and/or mutagenic nitroaromatic compounds upon irradiation of natural lake water and groundwater samples, proportionally to the nitrate levels. 相似文献