Experimental and Theoretical Studies for the Behavior of Strip Footing on Oil-Contaminated Sand

This paper presents the results of a series of plain-strain model tests carried out on both clean sand and oil-contaminated sand loaded with a rigid strip footing. The objectives of this study are to determine the influence of oil-contaminated sand on the bearing capacity characteristics and the settlement of the footing. Contaminated sand layers were prepared by mixing the sand with an oil content of 0–5% with respect to dry soil to match the field conditions. The investigations are carried out by varying the depth and the length of the contaminated sand layer and the type of oil contamination. A plain-strain elastoplastic theoretical model with an interface gap element between footing and the soil is carried out to verify the test results of the model. It is shown that the load-settlement behavior and ultimate bearing capacity of the footing can be drastically reduced by oil contamination. The bearing capacity is decreased and the settlement of the footing is increased with increasing the depth and the length of the contaminated sand layer. The agreement between observed and computed results is found to be reasonably good in terms of load-settlement behavior and effect of oil contamination on the bearing capacity ratio. A comparison between the model results and the prototype scale (B = 1.0?m) results are also studied.     

Human Cellular Retinol Binding Protein II Forms a Domain-Swapped Trimer Representing a Novel Fold and a New Template for Protein Engineering

Domain-swapping is a mechanism for evolving new protein structure from extant scaffolds, and has been an efficient protein-engineering strategy for tailoring functional diversity. However, domain swapping can only be exploited if it can be controlled, especially in cases where various folds can coexist. Herein, we describe the structure of a domain-swapped trimer of the iLBP family member hCRBPII, and suggest a mechanism for domain-swapped trimerization. It is further shown that domain-swapped trimerization can be favored by strategic installation of a disulfide bond, thus demonstrating a strategy for fold control. We further show the domain-swapped trimer to be a useful protein design template by installing a high-affinity metal binding site through the introduction of a single mutation, taking advantage of its threefold symmetry. Together, these studies show how nature can promote oligomerization, stabilize a specific oligomer, and generate new function with minimal changes to the protein sequence.     

Improving the adhesion strength of polymers: effect of surface treatments

Abstract

To improve their adhesion strength, polymeric surfaces are usually modified through different treatments. This study investigates the effect of mechanical, chemical, and energetic treatments on the bonding strength of ethylene propylene diene methylene (EPDM), polyvinyl chloride (PVC), and acrylonitrile butadiene styrene (ABS) materials. Three adhesives based on different chemical compositions, namely silicone, polyurethane, and modified-silane (MS) polymer, were considered. Results show that the effect of the applied treatments on the adhesion strength of EPDM surfaces is insignificant. Only a slight improvement is obtained in the case of polyurethane-based adhesive, while the failure modes remained adhesive. As for PVC, most treatments were effective in the case of the silicone-based adhesive, especially grit blasting, primer, and UV/ozone treatments. Only UV/ozone treatment improved the adhesion strength and altered the failure mechanisms of this material when polyurethane and MS-based adhesives are used. The adhesion of ABS increased and the failure modes changed from adhesive to cohesive for most treatments. Particularly, a significant improvement is obtained when primer coating and UV/ozone radiation are applied. This comparative study paves the way for the design of polymeric joints with highly enhanced adhesion performance.     

Liver microsomal membrane fluidity and microsomal desaturase activities in adult spontaneously hypertensive rats

OBJECTIVE: The purpose of the present study was to investigate liver microsomal membrane fluidity simultaneously with membrane fatty acid composition and desaturase activities in spontaneously hypertensive rats (SHR). DESIGN AND METHODS: The membrane fluidity was determined, after electron spin resonance (ESR) measurement, in SHR compared with normotensive Wistar-Kyoto (WKY) rats, by calculating the order parameter S from ESR spectra of 5-nitroxide stearate and 10-nitroxide stearate, used as spin-labelled fatty acids. Desaturase activities were measured by incubating SHR and WKY rat liver microsomes with [14C]-radiolabeled fatty acids as substrates for desaturation reactions. The fatty acid composition of liver microsomal membranes was determined by gas-liquid chromatography. RESULTS: Whereas no significant difference between S of 5-nitroxide stearate was observed for SHR and WKY rats, S of 10-nitroxide stearate was significantly lower in SHR than it was in WKY rat microsomal membrane, indicating that the core microsomal membrane fluidity was higher in SHR. Significant differences between fatty acid compositions were observed for SHR and WKY rat microsomal membranes. Delta9 and n-6 delta6 microsomal desaturase activities were significantly lower in SHR. CONCLUSION: These results suggest that the higher liver core microsomal membrane fluidity observed in SHR might be dependent on the increased proportion of mono-unsaturated fatty acids. Such observed modifications and the alterations in delta9 and n-6 delta6 desaturase activities suggest that an impaired polyunsaturated fatty acid biosynthesis is related to changes in microsomal membrane fluidity in hypertension.     

Improving the quality of Ras cheese made without starter

Trials were carried out to produce Ras cheese of good quality without the use of starter. Cheese was made from cows' milk, pasteurized and acidified with lactic acid or citric acid to pH 5·8; cheese was also made after adding 4·5 g glucono-δ-lactone per kg to the acidified curd. Control cheese was made by the traditional method.The cheese had poor body and texture, weak flavour intensity, and low levels of soluble nitrogen compounds and free volatile fatty acids.Incorporation into the cheese curd of mixtures containing Fromase 100 (fungal protease) and Piccantase B (fungal lipase) or Fromase 100 and Capalase K (animal lipase) enhanced flavour intensity and body characteristics and accelerated the formation of both soluble nitrogen compounds and free volatile fatty acids. The organoleptic properties of the experimental cheese with added enzymes were comparable to the control cheese.     

PVDF transducers generating Scholte waves

Shows that Scholte waves, propagated at a water/silica interface, may be generated by an interdigital transducer using a thin film of polyvinylidene fluoride as piezoelectric material     

Integrating logic and functional programming

The intent of this article is twofold: To survey prominent proposals for the integration of logic and functional programming and to present a new paradigm for the same purpose. We categorize current research into four types of approaches, depending on the level at which the proposed integration is achieved. Unlike most current work, our approach is not based on extending unification to general-purpose equation solving. Rather, we propose a computation delaying mechanism calledresiduation. This allows a clear distinction between functionalevaluation and logicaldeduction. The former is based on the-calculus, and the latter on Horn clause resolution. Residuation is built into the unification operation which may then account for-reduction. In clear contrast with equation-solving approaches, our model supports higher-order function evaluation and efficient compilation of both functional and logic programming expressions, without being plagued by non-deterministic term-rewriting. In addition, residuation lends itself naturally to process synchronization and constrained search. We describe an operational semantics and an implementation of a prototype language called LeFun—Logic, equations, and Functions.This article is a revised and extended version of [1].     

Modelling the effects of tool-edge radius on residual stresses when orthogonal cutting AISI 316L

Tool-edge geometry has significant effects on the cutting process, as it affects cutting forces, stresses, temperatures, deformation zone, and surface integrity. An Arbitrary-Lagrangian–Eulerian (A.L.E.) finite element model is presented here to simulate the effects of cutting-edge radius on residual stresses (R.S.) when orthogonal dry cutting austenitic stainless steel AISI 316L with continuous chip formation. Four radii were simulated starting with a sharp edge, with a finite radius, and up to a value equal to the uncut chip thickness. Residual stress profiles started with surface tensile stresses then turned to be compressive at about 140 μm from the surface; the same trend was found experimentally. Larger edge radius induced higher R.S. in both the tensile and compressive regions, while it had almost no effect on the thickness of tensile layer and pushed the maximum compressive stresses deeper into the workpiece. A stagnation zone was clearly observed when using non-sharp tools and its size increased with edge radius. The distance between the stagnation-zone tip and the machined surface increased with edge radius, which explained the increase in material plastic deformation, and compressive R.S. when using larger edge radius. Workpiece temperatures increased with edge radius; this is attributed to the increase in friction heat generation as the contact area between the tool edge and workpiece increases. Consequently, higher tensile R.S. were induced in the near-surface layer. The low thermal conductivity of AISI 316L restricted the effect of friction heat to the near-surface layer; therefore, the thickness of tensile layer was not affected.