Selective voltammetric determination of electroactive neuromodulating species in biological samples using iron(II) phthalocyanine modified multi-wall carbon nanotubes paste electrode

Iron(II) phthalocyanine (FePc) modified multi-wall carbon nanotubes paste electrodes (MWCNTPEs) were used as voltammetric sensors to selectively detect dopamine (DA) in the presence of serotonin (5-HT). The electrochemical behavior of DA at the new modified electrode was investigated using CV. The enhanced current response of DA indicates that FePc modification of the MWCNTPE surface results in a high catalytic activity for the redox reaction of DA. Differential pulse voltammetry was applied in detection of DA and 5-HT at FePc-MWCNTPE. The method parameters were optimized. Detection limit of 2.05 × 10⁻⁷ M was obtained for DA by using the electrocatalytic oxidation signal corresponding to the Fe^II/Fe^III redox process. The separation between the peak potentials of DA and 5-HT is 170 mV which is large enough for the simultaneously, selective determination of the two chemical species in their mixtures. There was no electrochemical response for ascorbic acid (AA) added in the sample. The monoamine neurotransmitter measuring method has been tested in analyzing deproteinized serum samples.     

The order of convexity of some general integral operators

The main object of the present paper is to discuss some extensions of certain integral operators and to obtain their order of convexity. Several other closely related results are also considered.     

On analyzing user preference dynamics with temporal social networks

The preferences adopted by individuals are constantly modified as these are driven by new experiences, natural life evolution and, mainly, influence from friends. Studying these temporal dynamics of user preferences has become increasingly important for personalization tasks in information retrieval and recommendation systems domains. However, existing models are too constrained for capturing the complexity of the underlying phenomenon. Online social networks contain rich information about social interactions and relations. Thus, these become an essential source of knowledge for the understanding of user preferences evolution. In this work, we investigate the interplay between user preferences and social networks over time. First, we propose a temporal preference model able to detect preference change events of a given user. Following this, we use temporal networks concepts to analyze the evolution of social relationships and propose strategies to detect changes in the network structure based on node centrality. Finally, we look for a correlation between preference change events and node centrality change events over Twitter and Jam social music datasets. Our findings show that there is a strong correlation between both change events, specially when modeling social interactions by means of a temporal network.     

The micromilling process for high aspect ratio microstructures

High aspect ratio microstructures are currently created by several processes which include lithography (X-ray, deep ultraviolet, etc.) and mechanical machining (diamond machining, microdrilling, etc.) The lithographic processes require more extensive processing equipment such as an energy source, mask/mask holder/mask aligner, photoresist and substrate, and chemical development capacity. In addition, these processes are serial in nature and each adds to the tolerances of the finished structure. The current mechanical processes provide for the direct removal of the substrate material in a single step but are more limited in the geometric patterns which can be created. In conventional machining, the process which provides the most versatility in geometric patterns is milling. The micromilling process has two basic components. The first is the fabrication of small milling cutters with very sharp cutting edges. The second is the actual removal of the workpiece material with a very precise and repeatable machine tool. Several basic cutter designs have been fabricated using focused ion beam micromachining and are undergoing testing. The cutter diameters are nominally 100 micrometers and 22 micrometers. Results have been obtained which show that this process can be very effective for the rapid fabrication of molds and mask structures.     

A Heuristic Search for Identifying Required Application Libraries Supporting a Run-Time Security Policy

On a Windows platform it is possible to inject a DLL into a running process creating a new thread of execution within an authorized process. Security tools monitoring or examining DLLs loaded into the memory space of a given process rely on policies to determine the validity of the library. Two approaches to the policy specification include “all or nothing” and “per executable” rules also referred to as a run-time security policy. Developing the run-time policy requires the running of every executable for a period of time to train the system. An alternative to the training method of the run-time approach is to determine ahead of time which DLL should be loaded before execution. A tool called LibMon was developed to monitor loading of libraries by running applications. A heuristic search algorithm was created based on the analysis of the data collected with LibMon.     

Computer-mediated communication in adolescents with and without a history of specific language impairment (SLI)

The various uses of computer-mediated communication (CMC) are transforming the nature of social interactions and human relations among adolescents. Little is known about engagement of exceptional youth with this technology. The present study investigated the implications of language and social factors for frequency of CMC use and its relationship to adolescent well-being in young people with and without a history of specific language impairment (SLI). Eighty six adolescents with a history of SLI and 90 typically developing 17 year olds participated. Participants completed standardized assessments of psycholinguistic abilities and self-report measures of language motivations and social motivations for CMC use, as well as anxiety and depression. Results indicate that language abilities have a complex relationship with frequency of CMC use; social abilities have a more direct association and are predictive of frequency of CMC use. Both adolescents with SLI and typically developing adolescents were less shy online. No association was obtained between frequency of CMC use and reported emotional symptoms of anxiety and/or depression. It is argued that the characteristics of CMC, in terms of its less stringent language demands and its reduced-cues environment, can provide a medium for positive adaptation of adolescents with communication challenges.     

The micromilling process for high aspect ratio microstructures

 High aspect ratio microstructures are currently created by several processes which include lithography (X-ray, deep ultraviolet, etc.) and mechanical machining (diamond machining, microdrilling, etc.). The lithographic processes require more extensive processing equipment such as an energy source, mask/mask holder/mask aligner, photoresist and substrate, and chemical development capacity. In addition, these processes are serial in nature and each adds to the tolerances of the finished structure. The current mechanical processes provide for the direct removal of the substrate material in a single step but are more limited in the geometric patterns which can be created. In conventional machining, the process which provides the most versatility in geometric patterns is milling. The micromilling process has two basic components. The first is the fabrication of small milling cutters with very sharp cutting edges. The second is the actual removal of the workpiece material with a very precise and repeatable machine tool. Several basic cutter designs have been fabricated using focused ion beam micromachining and are undergoing testing. The cutter diameters are nominally 100 micrometers and 22 micrometers. Results have been obtained which show that this process can be very effective for the rapid fabrication of molds and mask structures. Received: 30 October 1995 / Accepted: 4 March 1996     

Automatic detection of microaneurysms in colour fundus images for diabetic retinopathy screening

Regular eye screening is essential for the early detection and treatment of the diabetic retinopathy. This paper presents a novel automatic screening system for diabetic retinopathy that focuses on the detection of the earliest visible signs of retinopathy, which are microaneurysms. Microaneurysms are small dots on the retina, formed by ballooning out of a weak part of the capillary wall. The detection of the microaneurysms at an early stage is vital, and it is the first step in preventing the diabetic retinopathy. The paper first explores the existing systems and applications related to diabetic retinopathy screening, with a focus on the microaneurysm detection methods. The proposed decision support system consists of an automatic acquisition, screening and classification of diabetic retinopathy colour fundus images, which could assist in the detection and management of the diabetic retinopathy. Several feature extraction methods and the circular Hough transform have been employed in the proposed microaneurysm detection system, alongside the fuzzy histogram equalisation method. The latter method has been applied in the preprocessing stage of the diabetic retinopathy eye fundus images and provided improved results for detecting the microaneurysms.     

Polymerization in magnetic field: XVIII. Influence of surfactant nature on the synthesis and thermal properties of poly(methyl methacrylate) and poly[(methyl methacrylate)‐co‐(epoxypropyl methacrylate)]

BACKGROUND: The possibility to use β‐cyclodextrin as biodegradable tensioactive and an electromagnetic field in order to improve the kinetic parameters of radical emulsion polymerization is of interest. Thus, the influence of different surfactants—sodium lauryl sulfate (SLS) and β‐cyclodextrin (CD)—on the pathway of emulsion polymerization of methyl methacrylate (MMA) and emulsion copolymerization of MMA with 2,3‐epoxypropyl methacrylate (GMA) performed with or without the presence of a continuous electromagnetic field (MF) was studied. RESULTS: The presence of the MF leads to a considerable increase of the conversion during the first part of the reaction if the classic surfactant (SLS) is used. The reactions performed without MF and with CD exhibit a decrease of the conversion and of the polymerization rate as compared with the variants using SLS. The swelling rate and the maximum degree of swelling vary with the surfactant nature and with the reaction conditions and MF presence. Data from thermogravimetry and differential scanning calorimetry evidence the dependences between the polymer characteristics and the preparation conditions. CONCLUSION: This research underlines the coupling possibilities of the influence of a MF—growth of the reaction rate and conversion explained through radical pairs mechanism—with a combination of the ‘cage’ effect and ‘conformational control’ afforded by CD. The presence of MF and CD during the syntheses leads to an increase of T_g and an increase of PMMA and P(MMA‐co‐GMA) thermal stability. Copyright © 2007 Society of Chemical Industry     

- : an executable specification language for solving all problems in NP

In this paper a logic-based specification language, called - , is presented. The language is obtained by extending through allowing a limited use of some second-order predicates of predefined form. - programs specify solutions to problems in a very abstract and concise way, and are executable. In the present prototype they are compiled to code, which is run to construct outputs. Second-order predicates of suitable form allow to limit the size of search spaces in order to obtain reasonably efficient construction of problem solutions. - expressive power is precisely characterized as to express exactly the problems in the class NP. The specification of several combinatorial problems in - is shown, and the efficiency of the generated programs is evaluated.