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排序方式: 共有212条查询结果,搜索用时 62 毫秒
11.
Mauro F. La Russa Silvestro A. Ruffolo Natalia Rovella Cristina M. Belfiore Anna M. Palermo Maria T. Guzzi Gino M. Crisci 《Progress in Organic Coatings》2012
Environmental pollution arising from industrial implants and urban factors is constantly increasing, causing aesthetical and durability concerns to urban structures exposed to the atmosphere. 相似文献
12.
Martina Casarin Tiago Moderno Fortunato Saima Imran Martina Todesco Deborah Sandrin Giulia Borile Ilaria Toniolo Massimo Marchesan Gino Gerosa Andrea Bagno Filippo Romanato Emanuele Luigi Carniel Alessandro Morlacco Fabrizio Dal Moro 《International journal of molecular sciences》2022,23(5)
Bladder cancer (BC) is among the most common malignancies in the world and a relevant cause of cancer mortality. BC is one of the most frequent causes for bladder removal through radical cystectomy, the gold-standard treatment for localized muscle-invasive and some cases of high-risk, non-muscle-invasive bladder cancer. In order to restore urinary functionality, an autologous intestinal segment has to be used to create a urinary diversion. However, several complications are associated with bowel-tract removal, affecting patients’ quality of life. The present study project aims to develop a bio-engineered material to simplify this surgical procedure, avoiding related surgical complications and improving patients’ quality of life. The main novelty of such a therapeutic approach is the decellularization of a porcine small intestinal submucosa (SIS) conduit to replace the autologous intestinal segment currently used as urinary diversion after radical cystectomy, while avoiding an immune rejection. Here, we performed a preliminary evaluation of this acellular product by developing a novel decellularization process based on an environmentally friendly, mild detergent, i.e., Tergitol, to replace the recently declared toxic Triton X-100. Treatment efficacy was evaluated through histology, DNA, hydroxyproline and elastin quantification, mechanical and insufflation tests, two-photon microscopy, FTIR analysis, and cytocompatibility tests. The optimized decellularization protocol is effective in removing cells, including DNA content, from the porcine SIS, while preserving the integrity of the extracellular matrix despite an increase in stiffness. An effective sterilization protocol was found, and cytocompatibility of treated SIS was demonstrated from day 1 to day 7, during which human fibroblasts were able to increase in number and strongly organize along tissue fibres. Taken together, this in vitro study suggests that SIS is a suitable candidate for use in urinary diversions in place of autologous intestinal segments, considering the optimal results of decellularization and cell proliferation. Further efforts should be undertaken in order to improve SIS conduit patency and impermeability to realize a future viable substitute. 相似文献
13.
Sasso M. Talmant M. Haiat G. Naili S. Laugier P. 《IEEE transactions on ultrasonics, ferroelectrics, and frequency control》2009,56(11):2463-2470
Axial transmission techniques are particularly suitable for the ultrasonic assessment of cortical bone. The generic term "axial transmission technique" indicates a measurement configuration in which emitters and receivers are placed on the same side of the skeletal site, along the bone axis. Whereas axially transmitted signals are composed of several contributions, only the first arriving signal was shown to be a robust indicator of bone status, because its velocity discriminates osteoporotic from healthy patients in clinical studies. Later arrivals may provide additional bone indicators enhancing diagnostic value, but the precise determination of their velocities is challenging. In this paper, we focus on the most energetic contribution and we applied a singular-valuedecomposition- based extraction method not yet employed in the domain of bone assessment with the aim of determining the velocity of this contribution. Signals acquired in vitro on human radii, together with academic models, were used to reveal the relationship between the velocity of the most energetic component and bone properties. The velocity of the most energetic component is highly correlated to cortical layer thickness in the in vitro database (R2 = 0.6, P < 10-5; compared with R2 = 0.20, P < 10-2 for the first arriving signal), consistent with a flexural type of wave on regular tubes or plates. Conclusions are in agreement with published papers based on other axial transmission and signal processing approaches. 相似文献
14.
Aguiar Javier M. Baladrón Carlos De La Cuesta Borja Ordás Arnal Isabel Mignot Patrice Carrozzo Gino Comi Paolo 《IEEE network》2009,23(6):43-49
This article presents a new end-to-end architecture model that will enable the deployment of a plethora of different multimedia services from diverse suppliers competitively coexisting over a common access and home networking environment. The model is focused on personal multimedia communication services and terminals. The proposed model is a segmentation of the end-to-end multimedia chain into several business segments. The interfaces among segments and functional entities inside each segment are identified and defined in the work. In order to study the impact level of the results achieved, a comparison with the approximation to NGN provided by current standardization bodies in the field (3GPP and TISPAN) is also included in the article. This comparison highlights the advantages of using this model as a solution to offer PMC services. 相似文献
15.
R22, a hydrochlorofluorocarbon (HCFC), is used widely in the air-conditioning and refrigeration industry; however, it is being phased out along with other HCFCs, due to concerns about its impact on ozone depletion. In the EEC countries its production, commercialization and use will be forbidden before the end of 1999. According to the AREP (R22 Alternative Refrigerants Evaluation Program) project, coordinated by the Air-conditioning and Refrigeration Institute (ARI) a group of substances has been pointed out as potential ozone-free R22 alternatives. In this paper some working fluids, among those one considered by AREP, will be evaluated by means of a comparative thermodynamic analysis. Furthermore, particular interest will be paid to the environmental global impact joined to the substitution. To this aim, the Total Equivalent Warming Impact (TEWI) will be used as a tool to evaluate both direct and indirect contributions to the “greenhouse effect” linked to an operating vapour compression plant. 相似文献
16.
Carlo Paolo Sasso Peiqi Zheng Vittorio Basso Peter Müllner David C. Dunand 《Intermetallics》2011,19(7):952-956
The high surface/volume ratio and mechanical stability under cyclic strain makes polycrystalline Ni–Mn–Ga metallic foams attractive for magnetic refrigeration. By means of comparison with a polycrystalline bulk material, we have demonstrated that the porous structure of Ni54.8Mn20.2Ga25.0 open-cells metallic foams (porosity varying between 44% and 58%) reduces the temperature span of the phase transition and increases the magnetocaloric effect (MCE). MCE was investigated using calorimetry in a magnetic field. Temperature scan and isothermal experiments have shown a 0.8 K T?1 shift of the phase transition temperature and a maximum irreversible entropy change of 2.5 Jkg?1 K?1. The results indicate that metallic foams can represent a good approach for enhancing field induced phase transitions in magnetic refrigeration applications. 相似文献
17.
Appropriate knowledge of viscoelastic properties of polymers and elastomers is of fundamental importance for a correct modelization
and analysis of structures where such materials are present, especially when dealing with dynamic and vibration problems.
In this paper experimental results of a series of compression and tension tests on specimens of styrene-butadiene rubber and
polypropylene plastic are presented; tests consist of creep and relaxation tests, as well as cyclic loading at different frequencies.
Experimental data are then used to calibrate some linear viscoelastic models; besides the classical approach based on a combination
in series or parallel of standard mechanical elements as springs and dashpots, particular emphasis is given to the application
of models whose constitutive equations are based on differential equations of fractional order (Fractional Derivative Model).
The two approaches are compared analyzing their capability to reproduce all the experimental data for given materials; also,
the main computational issues related with these models are addressed, and the advantage of using a limited number of parameters
is demonstrated. 相似文献
18.
19.
Gino Moretti 《Computers & Fluids》1982,10(1):51-86
A new computational technique, involving the formation of grids by conformal mappings, the use of the λ-scheme and of shock fittings is applied to solve the Navier-Stokes equations which describe the flow field behind the precursor shock consequent to the firing of a gun, until the bullet is entirely out of the barrel. The numerical analysis is presented in detail and reasons for the choice of the technique are discussed. Three examples are presented, discussed and compared with experimental results. 相似文献
20.
We explore the possibility of generating high-velocity flows of nanoparticles through flat-rectangular nanochannels, which are only 50% deeper than the diameter of the particles. Using the shear-driven flow principle, 200-nm particles can, for example, be transported through a 300-nm-deep channel at velocities up to 35 mm/s (upper limit of our current setup). Working under high-pH conditions, the velocity of the carboxylated nanoparticles still respects the small-molecule velocity law, despite the high degree of confinement to which the particles are subjected. The high degree of confinement is also found to lead to a reduced band broadening. When injecting sharply delimited particle plugs, the plate heights observed for the flow of 0.2-microm particles through a 0.3-microm channel (with plate heights of the order of 1-2 microm) are, for example, approximately 1 order of magnitude smaller than for the flow of 1.0-microm particles through a 1.4-microm channel. It is also found that the band broadening is, within its statistical variation, independent of the fluid velocity over a large range of particle velocities (5-35 mm/s). The flow method distinguishes itself from pressure-driven field-flow fractionation and hydrodynamic chromatography in that the mean particle velocity is independent of the particle size over the entire range of possible particle to channel diameter ratios. 相似文献