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51.
Dante Rotili Dr. Domenico Tarantino Dr. Vincenzo Carafa Dr. Ester Lara Dr. Sarah Meade Dr. Giorgia Botta Dr. Angela Nebbioso Dr. Jörg Schemies Dr. Manfred Jung Prof. Aleksey G. Kazantsev Prof. Manel Esteller Prof. Mario F. Fraga Dr. Lucia Altucci Prof. Antonello Mai Prof. 《ChemMedChem》2010,5(5):674-677
52.
Perniola L. Bernardini S. Iannaccone G. Masson P. Barbara De Salvo Ghibaudo G. Gerardi C. 《Nanotechnology, IEEE Transactions on》2005,4(3):360-368
We propose an analytical model of the effects of a nonuniform distribution of trapped charge on the electrical characteristics and on the perspectives of 2-bit operation of discrete-trap memories. To keep the model tractable, we consider an idealized nonuniform distribution, represented by a step function, so that the concentration of trapped charge can assume only two possible values in two different regions. Notwithstanding the simplicity of our assumptions, which limits the range of validity of our model to the subthreshold and weak inversion regions of the I-V characteristics, we can investigate a series of important aspects for 2-bit storage of nonvolatile memories. Our model is then validated through comparison with detailed numerical simulations performed with a commercial technology computer-aided design tool, and with the experimental electrical characteristics of nanocrystal flash memories under different bias conditions. Finally, we provide a method, based on our model, to extract an "effective" distribution of trapped charge, in which all charge is uniformly distributed in a localized region close to the drain. 相似文献
53.
54.
Samanta Salvi Daniele Calistri Giorgia Gurioli Elisa Carretta Luigi Serra Roberta Gunelli Wainer Zoli Valentina Casadio 《International journal of molecular sciences》2014,15(7):12458-12468
Patients with non-muscle invasive bladder cancer (NMIBC) generally have a high risk of relapsing locally after primary tumor resection. The search for new predictive markers of local recurrence thus represents an important goal for the management of this disease. We studied the copy number variations (CNVs) of 24 oncogenes (MDM4, MYCN, ALK, PDGFRA, KIT, KDR, DHFR, EGFR, MET, SMO, FGFR1, MYC, ABL1, RET, CCND1, CCND2, CDK4, MDM2, AURKB, ERBB2, TOP2A, AURKA, AR and BRAF) using multiplex ligation probe amplification technique to verify their role as predictive markers of recurrence. Formalin-fixed paraffin-embedded tissue samples from 43 patients who underwent transurethral resection of the bladder (TURB) were used; 23 patients had relapsed and 20 were disease-free after 5 years. Amplification frequencies were analyzed for all genes and MDM4 was the only gene that showed significantly higher amplification in non recurrent patients than in recurrent ones (0.65 vs. 0.3; Fisher’s test p = 0.023). Recurrence-free survival analysis confirmed the predictive role of MDM4 (log-rank test p = 0.041). Our preliminary results indicate a putative role for the MDM4 gene in predicting local recurrence of bladder cancer. Confirmation of this hypothesis is needed in a larger cohort of NMIBC patients. 相似文献
55.
Giorgia Stocco Andrea Summer Claudio Cipolat-Gotet Massimo Malacarne Alessio Cecchinato Nicolò Amalfitano Giovanni Bittante 《Journal of dairy science》2021,104(8):8439-8453
Natural variations in milk minerals, their relationships, and their associations with the coagulation process and cheese-making traits present an opportunity for the differentiation of milk destined for high-quality natural products, such as traditional specialties or Protected Designation of Origin (PDO) cheeses. The aim of this study was to quantify the effects of the native contents of Ca, P, Na, K, and Mg on 18 traits describing traditional milk coagulation properties (MCP), curd firming over time (CFt) equation parameters, cheese yield (CY) measures, and nutrient recoveries in the curd (REC) using models that either included or omitted the simultaneous effects of milk fat and casein contents. The results showed that, by including milk fat and casein and the minerals in the statistical model, we were able to determine the specific effects of each mineral on coagulation and cheese-making efficiency. In general, about two-thirds of the apparent effects of the minerals on MCP and the CFt equation parameters are actually mediated by their association with milk composition, especially casein content, whereas only one-third of the effects are direct and independent of milk composition. In the case of cheese-making traits, the effects of the minerals were mediated only negligibly by their association with milk composition. High Ca content had a positive effect on the coagulation pattern and cheese-making traits, favoring water retention in the curd in particular. Phosphorus positively affected the cheese-making traits in that it was associated with an increase in CY in terms of curd solids, and in all the nutrient recovery traits. However, a very high P content in milk was associated with lower fat recovery in the curd. The variation in the Na content in milk only mildly affected coagulation, whereas with regard to cheese-making, protein recovery was negatively associated with high concentrations of this mineral. Potassium seemed not to be actively involved in coagulation and the cheese-making process. Magnesium content tended to slow coagulation and reduce CY measures. Further studies on the relationships of minerals with casein and protein fractions could deepen our knowledge of the role of all minerals in coagulation and the cheese-making process. 相似文献
56.
Salvatore D’Aquino Innocenza Chessa Paolo Inglese Giorgia Liguori Giuseppe Barbera Maria Judith Ochoa Daniela Satta Amedeo Palma 《Food and Bioprocess Technology》2017,10(8):1466-1478
Pre-storage high-temperature conditioning (HTC, 38 °C, and 95% RH for 24 h) and individual film wrapping (IFW) with a perforated polyolefinic heat-shrinkable film were used as individual treatments or in combination to mitigate chilling injury of first crop cactus pear cv ‘Gialla’. The fruit was stored for 21 days at either 2 or 8 °C (CS) plus 1 week of simulated marketing conditions (SMC) at 20 °C. The reduction in peel disorders and decay in HTC-treated fruit stored at 2 °C was comparable to that detected in control fruit stored at 8 °C. IFW was more efficient than HTC in reducing peel disorders, almost completely inhibited weight loss, and preserved freshness in fruit stored at 8 °C as well as in those stored at 8 °C. The internal quality of the fruit (pH, total soluble solids, titratable acidity, vitamin C, polyphenols, betaxanthins, antioxidant capacity, acetaldehyde, and ethanol) was slightly affected by treatments. Combining HTC with IFW did not improve fruit tolerance to low temperature but reduced decay with respect to individual treatments. IFW with a perforated film in combination with HTC is a good means of overcoming the stringent conditions of cold quarantine treatments, maintaining fruit freshness and reducing decay in cold-stored cactus pears. 相似文献
57.
Luca Antonioli Carolina Pellegrini Matteo Fornai Laura Benvenuti Vanessa DAntongiovanni Rocchina Colucci Lorenzo Bertani Clelia Di Salvo Giorgia Semeghini Concettina La Motta Laura Giusti Lorenzo Zallocco Maurizio Ronci Luca Quattrini Francesco Angelucci Vito Coviello Won-Keun Oh Quy Thi Kim Ha Zoltan H. Nmeth Gyorgy Hask Corrado Blandizzi 《International journal of molecular sciences》2021,22(12)
Acadesine (ACA), a pharmacological activator of AMP-activated protein kinase (AMPK), showed a promising beneficial effect in a mouse model of colitis, indicating this drug as an alternative tool to manage IBDs. However, ACA displays some pharmacodynamic limitations precluding its therapeutical applications. Our study was aimed at evaluating the in vitro and in vivo effects of FA-5 (a novel direct AMPK activator synthesized in our laboratories) in an experimental model of colitis in rats. A set of experiments evaluated the ability of FA5 to activate AMPK and to compare the efficacy of FA5 with ACA in an experimental model of colitis. The effects of FA-5, ACA, or dexamethasone were tested in rats with 2,4-dinitrobenzenesulfonic acid (DNBS)-induced colitis to assess systemic and tissue inflammatory parameters. In in vitro experiments, FA5 induced phosphorylation, and thus the activation, of AMPK, contextually to the activation of SIRT-1. In vivo, FA5 counteracted the increase in spleen weight, improved the colon length, ameliorated macroscopic damage score, and reduced TNF and MDA tissue levels in DNBS-treated rats. Of note, FA-5 displayed an increased anti-inflammatory efficacy as compared with ACA. The novel AMPK activator FA-5 displays an improved anti-inflammatory efficacy representing a promising pharmacological tool against bowel inflammation. 相似文献
58.
G. Molas M. Bocquet E. Vianello L. Perniola H. Grampeix J.P. Colonna L. Masarotto F. Martin P. Brianceau M. Gély C. Bongiorno S. Lombardo G. Pananakakis G. Ghibaudo B. De Salvo 《Microelectronic Engineering》2009,86(7-9):1796-1803
In this paper, we evaluate the potentiality of high-k materials (Al2O3, HfO2 and HfAlO) for interpoly application in non-volatile memories. A study of the leakage currents of high-k based capacitors allowed to discuss the retention performances at room and high temperatures of high-k interpoly dielectrics. High-k materials are then integrated as control dielectrics in silicon nanocrystal and SONOS (Si/SiO2/Si3N4/SiO2/Si) memories. The role of the high-k layer on the memory performances is discussed; a particular attention being devoted to the retention characteristics. Analytical models, combined with experimental results obtained on various structures allowed to analyze the mechanisms involved during retention. 相似文献
59.
Marilena Pariano Stefania Pieroni Antonella De Luca Rossana G. Iannitti Monica Borghi Matteo Puccetti Stefano Giovagnoli Giorgia Renga Fiorella DOnofrio Marina M. Bellet Claudia Stincardini Maria Agnese Della-Fazia Giuseppe Servillo Frank L. van de Veerdonk Claudio Costantini Luigina Romani 《International journal of molecular sciences》2021,22(12)
60.
Luciano Atzori Maria Giorgia Cutrufello Daniela Meloni Barbara Onida Delia Gazzoli Andrea Ardu Roberto Monaci Maria Franca Sini Elisabetta Rombi 《Frontiers of Chemical Science and Engineering》2021,15(2):251-268
Nanosized NiO,CeO2 and NiO-CeO2 mixed oxides with different Ni/Ce molar ratios were prepared by the soft template method.All the samples were characterized by different techniques as to their chemical composition,structure,morphology and texture.On the catalysts submitted to the same reduction pretreatment adopted for the activity tests the surface basic properties and specific metal surface area were also determined.NiO and CeO2 nanocrystals of about 4 nm in size were obtained,regardless of the Ni/Ce molar ratio.The Raman and X-ray photoelectron spectroscopy results proved the formation of defective sites at the NiO-CeO2 interface,where Ni species are in strong interaction with the support.The microcalorimetric and Fourier transform infrared analyses of the reduced samples highlighted that,unlike metallic nickel,CeO2 is able to effectively adsorb CO2,forming carbonates and hydrogen carbonates.After reduction in H2 at 400°C for 1 h,the catalytic performance was studied in the CO and CO2 co-methanation reaction.Catalytic tests were performed at atmospheric pressure and 300°C,using CO/CO2/H2 molar compositions of 1/1/7 or 1/1/5,and space velocities equal to 72000 or 450000 cm3?h-1?gcat-1.Whereas CO was almost completely hydrogenated in any investigated experimental conditions,CO2 conversion was strongly affected by both the CO/CO2/H2 ratio and the space velocity.The faster and definitely preferred CO hydrogenation was explained in the light of the different mechanisms of CO and CO2 methanation.On a selected sample,the influence of the reaction temperature and of a higher number of space velocity values,as well as the stability,were also studied.Provided that the Ni content is optimized,the NiCe system investigated was very promising,being highly active for the COx co-methanation reaction in a wide range of operating conditions and stable(up to 50 h)also when submitted to thermal stress. 相似文献