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61.
    
Molecularly engineered novel dopant‐free hole‐transporting materials for perovskite solar cells (PSCs) combined with mixed‐perovskite (FAPbI3)0.85(MAPbBr3)0.15 (MA: CH3NH3+, FA: NH=CHNH3+) that exhibit an excellent power conversion efficiency of 18.9% under AM 1.5 conditions are investigated. The mobilities of FA‐CN, and TPA‐CN are determined to be 1.2 × 10?4 cm2 V?1 s?1 and 1.1 × 10?4 cm2 V?1 s?1, respectively. Exceptional stability up to 500 h is measured with the PSC based on FA‐CN. Additionally, it is found that the maximum power output collected after 1300 h remained 65% of its initial value. This opens up new avenue for efficient and stable PSCs exploring new materials as alternatives to Spiro‐OMeTAD.  相似文献   
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The aim of this study was to estimate the hydrolytic degree and antioxidant activity of purified casein characterised by different haplotypes (αs1-, β- and k-casein) after in vitro digestion with two different enzymatic systems: pepsin from porcine gastric mucosa (EP) and a crude enzymatic extract from the edible mushroom Pleurotus eryngii. The used enzymes showed a different mode of casein catalysis with a consequent production of peptides of different antioxidant activity. The CN haplotype significantly influenced peptides production; in fact, the amino acid substitutions caused by genetic polymorphisms at the αs1-, β- and k-CN loci influenced the sites of enzymatic cleavage and therefore the produced peptides. The above is evidenced by the different antioxidant activity found in the hydrolysates depending on the used enzymatic system, the CN haplotype, and the CN haplotype × enzymatic treatment interaction. The findings of this study are a perspective for the production of specific foods that exert a biological effect in addition to the nutritional one.  相似文献   
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Benign prostatic hyperplasia (BPH) is an age-related chronic disorder, characterized by the hyperproliferation of prostatic epithelial and stromal cells, which drives prostate enlargement. Since BPH aetiology and progression have been associated with the persistence of an inflammatory stimulus, induced both by Nuclear Factor-kappa B (NF-κB) activation and reactive oxygen species (ROS) production, the inhibition of these pathways could result in a good tool for its clinical treatment. This study aimed to evaluate the antioxidant and anti-inflammatory activity of a combined formulation of Serenoa repens and Urtica dioica (SR/UD) in an in vitro human model of BPH. The results confirmed both the antioxidant and the anti-inflammatory effects of SR/UD. In fact, SR/UD simultaneously reduced ROS production, NF-κB translocation inside the nucleus, and, consequently, interleukin 6 (IL-6) and interleukin 8 (IL-8) production. Furthermore, the effect of SR/UD was also tested in a human androgen-independent prostate cell model, PC3. SR/UD did not show any significant antioxidant and anti-inflammatory effect, but was able to reduce NF-κB translocation. Taken together, these results suggested a promising role of SR/UD in BPH and BPH-linked disorder prevention.  相似文献   
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This research has 6 fundamental aims: (i) to present a modified version of Taylor's interpolation, one that is more effective and faster than the original; (ii) outline the capability of artificial neural networks (ANNs) to perform an optimal functional approximation of the digital elevation model reconstruction from a satellite map, using a small and independent sample of Global Positioning System observations; (iii) demonstrate experimentally how ANNs outperform the traditional and most used algorithm for the height interpolation (Taylor's interpolation); (iv) introduce a new ANN, the Conic Net, able to outperform the results of the classic and more known multilayer perceptron; (v) determine that Conic Nets, even when using Taylor's modified interpolation as input features, are able to optimally approximate the heights with one order of magnitude more than the original satellite map; and (vi) make evident the possibility to interpolate the DEM heights through an ANN, which learns a data set of known points.  相似文献   
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Particles that preferentially partition to a specific cellular subunit, such as the nucleus, mitochondria, or the cytoskeleton, are of relevance to a number of applications, including drug delivery, genetic manipulation, or self‐assembly. Here, hierarchical assemblies of fully synthetic particles that selectively localize to the plasma membrane of mammalian cells are presented. A multimodal approach is used to create assemblies of polymer‐based carrier particles with amphiphilic gold nanoparticles immobilized on one hemisphere. These assemblies persist in the plasma membrane of cells for several days and undergo rearrangements and clustering, typically considered to be hallmarks of membrane‐bound receptors.  相似文献   
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In the literature there are many experimental results of multiaxial fatigue testing, usually generated by the combination of two or more cyclical loads. The cases in which samples are randomly stressed are rarer. Moreover, to generate particular stress states, the use of specific machinery for fatigue tests is usually required. For these reasons, the authors have created a particular geometry of specimens, which, when solicited by a single input of a random type, guarantees the creation of specific multiaxial stress states without using complex and costly instruments. The experimental tests were finally used for the validation of the multiaxial reduction method developed and currently utilized in the authors' design phase, though potentially used to verify all the other methodologies present in the literature.  相似文献   
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This article takes a critical look at Machine Translation of legal text, especially global legislation, through the discussion of Global-Regulation, a state of the art online search engine of the world’s legislation in English. Part 2 explains the rationale for an online platform such as Global-Regulation. Part 3 provides a brief account of the history of the development of machine translation, and it describes some of the limits of the use of statistical machine translation for translating legal texts. Part 4 describes Neural Machine Translation (NMT), which is a new generation of machine translation systems. Finally, Parts 5 and 6 outline the ‘big sky’ thoughts on future directions for Global-Regulation.  相似文献   
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