Recombinant proteins containing oxytocin oligomeric sequences

Obstetric patients are considered to be at increased risk of anaesthesia-related Aspiration Pneumonitis. Less is known about the incidence and morbidity of this complication in younger women undergoing gynaecological surgery. We performed a 4-year audit of perioperative Aspiration Pneumonitis, defined as bronchospasm, hypoxia, cough and dyspnea, together with radiographic or auscultatory abnormalities, following a witnessed episode of gastric content entering the trachea or an intraoperative episode making pulmonary aspiration likely, in two larger Norwegian hospitals. Eleven cases were identified; 4 in Caesarean Section (C-section) patients, 5 in gynaecological (GYN) outpatients and 2 in GYN inpatients, with incidences of 0.11%, 0.04% and 0.01% respectively (P = 0.03). Risk factors were present in all patients. No patient died, but the short-time morbidity in the form of prolonged ICU stay and hospitalisation was significant. At discharge all patients noted symptoms of dyspnea, cough, and tightness of the chest; symptoms explainable by bronchial hyperreactivity. Five patients felt these symptoms did not disappear within 3 months and were followed up for a median of 2 years (range 4 months to 4 years). All were smokers and had multiple confounding causes, which made it hard to link their prolonged complaints directly to the pulmonary aspiration incident. All experienced improvement of symptoms during the follow-up period. Compared to gynaecological patients of similar age, C-section patients still have an increased risk of suffering Aspiration Pneumonitis. Prevention can be further improved in both groups. A cause-relationship between the incidence and respiratory complaints lasting longer than 3 months could not be established, and a structured follow-up may be helpful to avoid later medicolegal claims.     

Risk factors for early work disability in systemic lupus erythematosus: results from a multicenter study

OBJECTIVE: To study the risk factors for early work disability in systemic lupus erythematosus (SLE). METHODS: A sample of 159 SLE patients who had been employed at some time since diagnosis was drawn from a multicenter study of outcome in SLE. Disease activity, organ damage, education, income, source of health insurance, and work-related factors were measured in a standardized interview. Work disability was defined by patient self-report of not working because of SLE. The outcome measure was current work status. Seven patients were excluded from the analysis because their choice not to work was unrelated to SLE. RESULTS: An average of 3.4 years after diagnosis, 40% had quit work completely, and job modification was substantial. Univariate analysis (chi-square and t-test) showed that significant predictors of early work disability included having a high school education or less, receiving Medicaid or having no health insurance, having a job which required more physical strength, having an income below poverty level, and having greater disease activity at diagnosis. In multivariate models, significant predictors were education level (P = 0.0004), higher physical demands of the job (P = 0.0028), and higher disease activity at diagnosis (P = 0.0078). Race, sex, cumulative organ damage at diagnosis, and disease duration were not significant. CONCLUSION: Early work disability in SLE is strongly associated with some sociodemographic factors that might be amenable to intervention.     

Fatal air embolism following gunshot wound of the lung

Air embolism following penetrating lung trauma has been reported infrequently and its existence is questioned. A death resulting from air embolism following a high-velocity gunshot wound is presented. Appropriate treatment and preventive measures are discussed.     

The prognostic factors of arterialized bypass veins in the lower extremities

Two children with cystitis presented with multiple filling defects in the urinary bladder. They were proven to be cases of cystitis glandularis with proliferative changes of the bladder epithelium. The radiographic findings are described and the differential diagnosis from neoplasms is outlined.     

Rare diseases of the abdominal organs simulating malignant tumors

The results of local cerebral blood flow examinations were analysed in 20 patients in the postoperative period. The dynamics of the restoration of the vascular responses to functional tests was observed. A study of the changes of the local cerebral blood flow following the administration of Rheopolyglukin demonstrated its high efficacy. The rationale of a combined employment of dehydration drugs and agents improving the rheological properties of blood is emphasized.