Framing the construct of life satisfaction in terms of older adults' personal goals.

Older adults' life satisfaction can be better understood in light of their personal goals. This study of 179 elders examined (1) how goals correlate with satisfaction, (2) whether elders maintain satisfaction by accommodating goals to past losses, and (3) how correlations between satisfaction and key predictors differ among groups with different goals. Satisfaction was related positively to social maintenance and energetic lifestyle goals and negatively to concerns for improvement, disengagement, stability, and reduced activity. Past losses were correlated with current goals but not with satisfaction, consistent with the notion of accommodation. A cluster analysis identified 5 patterns of goals: high demand, age prescribed, self-focused, socially engaged, and low demand. Correlations between satisfaction and other predictors differed by cluster, suggesting that the determinants of elders' satisfaction depend on personal goals. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Tissue-specific mRNA expression of a calcitonin receptor-like receptor during fetal and postnatal development

The distribution of calcitonin receptor-like receptor (CRLR) mRNA in developing rats was investigated by in situ hybridization. Signals were found in the piriform cortex, the central and basolateral amygdala and the amygdalostriatal transition area. Among peripheral organs, the CRLR was predominantly expressed in the lung. mRNA expression in blood vessels, liver, midgut, rectum and urethra was restricted to gestational days 16 and/or 20. The CRLR was thought to be a calcitonin gene-related peptide (CGRP) type 1 receptor (Aiyar et al., J. Biol. Chem., 271 (1996) 11325-11329). This contrasts with previously reported evidence that the CRLR is an orphan receptor with no identifiable interactions with CGRP and other related ligands (Flühmann et al., Biochem. Biophys. Res. Commun., 206 (1995) 341-347). In situ hybridization signals have not been detected in the cerebellum and the spleen known to present a high density of CGRP binding sites. The different regional distribution of CGRP receptor binding sites and CRLR mRNA implies the latter encoding a different CGRP receptor subtype.     

Physeal and periphyseal injuries of the hand. Patterns of injury and results of treatment

To the authors' knowledge, this is the largest study assembled of finger fractures in children. Distribution of fractures according to location within the hand (see Fig. 1), location within the phalanges themselves, and the percent of epiphyseal fractures as well as the age distribution of the patients are all similar to what has previously been presented in smaller studies. Previously unreported synchronous and double epiphyseal injuries were identified. For the most part, thanks to the remodeling capacity and rapid healing of children's bone, treatment is short and complications are few. Nevertheless, as in other locations, there is a limited capacity to remodel angular deformity and no capacity to remodel rotational deformity. The clinical information in our study conflicts somewhat with previously described anatomic information about the insertion of ligaments with respect to the growth plate. Bogumill and Hankin and Janda have suggested that the ligaments insert primarily on the epiphysis in the proximal phalanx, and on the epiphysis and metaphysis in the middle and distal phalanges. Taken by itself, this information would suggest that a Salter-Harris III mechanism would be relatively more common at the MP joint, and the Salter-Harris II and IV mechanism (where the proximal fragment includes bone both proximal and distal to the growth plate at the point where the ligament is attached) would be relatively more common at the more distal levels. In fact, the opposite was true. The Salter-Harris II mechanism made up an overwhelming majority of the percentage of injuries of the MP joint, whereas the Salter-Harris III mechanism predominated at the PIP joint and was relatively common at the DIP joint as well. This would seem to suggest that either the contribution of ligament insertion distal to the growth plate of the PIP and DIP joints is not functionally important or that other factors are involved in the injury mechanism at both levels and play a role in producing these injuries. Further study will be required, possibly involving experimental fracture production to help elucidate this issue. Finally, it is critical to recognize and properly treat the four major categories of injury that constitute a small percentage of the total but a large percentage of the complications. The condylar and subcondylar fractures must be identified by obtaining a true lateral film by whatever means necessary. If undisplaced, they need to be adequately immobilized, possibly including the entire arm of a small child, and if displaced, they almost always require internal fixation.(ABSTRACT TRUNCATED AT 400 WORDS)     

On the phase diagram of the system hydroxypropylcellulose-water

The phase diagram of the system hydroxypropylcellulose (HPC)-H₂O has been investigated using differential scanning calorimetry (DSC), X-ray diffraction, optical microscopy and¹H (NMR) nuclear magnetic resonance spectroscopy. A peritectic line at higher temperatures has been found similar to the lytropic systems described before. This phase transition, from a solution consisting of solvate aggregates and free solvent, into a crystal solvate-isotropic phase system is completely reversible. The formation of crystal solvate phases is independent of the water content of the system until the system transforms into a thermotropic system. The solvent molecules are strongly associated with the macromolecules.     

Transplantation of pediatric en bloc cadaver kidneys into adult recipients

BACKGROUND: To maximize the renal donor pool, cadaveric pediatric en bloc kidneys have been transplanted as a dual unit by some transplant centers. We compared the short- and long-term outcomes of adult recipients of cadaveric pediatric en bloc renal transplants versus those of matched recipients of cadaveric adult kidneys. METHODS: Thirty-three adults who received pediatric en bloc kidney transplants between April 1990 and September 1997 were retrospectively identified and were compared with 33 matched adults who received adult cadaveric kidney transplants. The groups were identical for transplantation era, immunosuppression, recipient sex, race, cause of renal failure, mean weight, and follow-up duration (37.8 vs. 37.5 months). The mean recipient age study versus control was lower (36.3 vs. 48.9 years, P=0.0003). Results. There was no difference between the en bloc and adult donor groups in the 3-year patient survival rates (95% vs. 87%, P=0.16) or the 3-year graft survival rates (87.3% vs. 84.2%, P=0.35). Further, there was no difference in en bloc patient or en bloc graft survival time stratified by recipient age (14-44 vs. >45 years, P=0.11), en bloc donor age (<24 vs. >24 months, P=0.39), or recipient weight (<60, 61-75, >75 kg; P=0.60). Differences in serum creatinine (mg/dl) for the en bloc versus the control group at the time of discharge (3.0 vs. 7.8 mg/dl, P=0.06), at 1 year (1.4 vs. 2.0 mg/dl, P=0.06), and at 2 years (1.1 vs. 1.6 mg/dl, P=0.14) had dissipated by the time of the 5-year follow-up examination (1.1 vs. 1.6 mg/dl, P=0.14). Vascular complications were more prevalent in the en bloc group: renal vein thrombosis (one case), thrombosis of donor aorta (two cases), arterial thrombosis of one renal moiety (two cases), and renal artery stenosis (two cases). There were no differences between groups in delayed graft function, acute or chronic rejection, posttransplant hypertension, posttransplant protein-uria, or long-term graft function. CONCLUSIONS: Collectively, these data indicate that transplanting pediatric en bloc kidneys into adult recipients results in equivalent patient and graft survival compared with adult cadaveric kidneys. Further, the data also suggest that pediatric en bloc kidneys need not be strictly allocated based on recipient weight or age criteria.     

Cognitive View of Reuse and Redesign

Reusable components are not enough. Program designers need tools that help them understand the components and how to use them. Fortunately, some support tools do exist.     

Effect of reliability on the efficiency of communication systems

Reliability consideration of performance systems is an important problem of today. The results obtained by using the well known theoretical foundations of reliability are not sufficient. Therefore a new reliability concept for performance systems is developed. A main aspect of this concept is to use the reliability as an independent variable while system efficiency is used as a dependent variable. The introduced concept is illustrated with the help of a parallel structure as well as a nonseries parallel structure.