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51.
52.
Kehoe Priscilla; Shoemaker William J.; Triano Laura; Callahan Megan; Rappolt Gabrielle 《Canadian Metallurgical Quarterly》1998,112(1):116
Adult rats that were isolated from the mother and nest for 1 hr per day from Postnatal Day 2 to 9 were studied. Controls consisted of handled littermates as well as separate litters that were never handled. As adults, animals were given either a pharmacological challenge (1.0 or 2.0 mg/kg amphetamine) or an environmental challenge (restraint). Previously isolated animals demonstrated increased activity compared to controls at both drug doses. Similarly, isolated animals manifested exaggerated inhibition of activity after restraint. Previously isolated animals usually did not show differences compared to controls under baseline conditions (saline injection or no restraint). The neuroplastic changes that result from the neonatal experience are long lasting and appear when the system is challenged. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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54.
Hospitals are increasingly attempting to integrate their operations with physician constituents through the development of hospital-physician joint ventures and acquisition of physician practices. This article provides an overview of valuation-related issues that result with respect to such affiliation efforts and guidance to assist the health care financial and legal professional in resolving such issues consistent with the business objectives of the transaction parties. 相似文献
55.
This paper presents a multifaceted method for teaching engineering mechanics designed to satisfy the following set of desiderata: (1) integrate engineering practice into the teaching of engineering science; (2) address a wide set of learning styles; (3) provide opportunities for practice in group work and learning; (4) promote communication and synthesizing skills; (5) engage students in the teaching and learning process; (6) maintain traditional achievement levels with respect to traditional measures; (7) motivate students to continue their engineering studies; and (8) maintain reasonable resource demands. Consistent with this variety of objectives, the approach presented here is composed of a variety of ingredients. In addition to the standard homework problems and exams, these ingredients include design projects, group work, basic competency exams, computational environments for simulating and visualizing phenomena, multimedia instructional tools, hands-on experiences, and student presentations. This educational model is intended to be suitable for teaching engineering mechanics in general, but this paper focuses on a particular sophomore-level mechanics of materials course in which the method has been implemented, refined over several years of classroom use, and tested relative to traditional approaches. The paper describes the and techniques that together make up the method, followed by summaries of the results of evaluations that have been applied to the course. 相似文献
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Tracy L. Westeyn Gregory D. Abowd Thad E. Starner Jeremy M. Johnson Peter W. Presti Kimberly A. Weaver 《Personal and Ubiquitous Computing》2012,16(2):169-191
Previous research has established the connection between the way in which children interact with objects and the potential
early identification of children with autism. Those findings motivate our own work to develop "smart toys," objects embedded with wireless sensors that are safe and enjoyable for very small children, that allow detailed interaction
data to be easily recorded. These sensor-enabled toys provide opportunities for autism research by reducing the effort required
to collect and analyze a child’s interactions with objects. In the future, such toys may be a useful part of clinical and
in-home assessment tools. In this paper, we discuss the design of a collection of smart toys that can be used to automatically
characterize the way in which a child is playing. We use statistical models to provide objective, quantitative measures of
object play interactions. We also developed a tool to view rich forms of annotated play data for later analysis. We report
the results of recognition experiments on more than fifty play sessions conducted with adults and children as well as discuss
the opportunities for using this approach to support video annotation and other applications. 相似文献
58.
Diana R. Melis Chiao-Yu Hsiao Dr. Jill M. Combrinck Prof. Lubbe Wiesner Prof. Gregory S. Smith 《Chembiochem : a European journal of chemical biology》2021,22(9):1568-1572
A fluorescent analogue of a previously synthesised N,N-chelated IrIII complex was prepared by coordination of the organic ligand to an extrinsic bis(2-phenylpyridine)iridium(III) fluorophore. This cyclometallated IrIII complex in itself displays good, micromolar activity against the chloroquine-sensitive NF54 strain of Plasmodium falciparum. Live-cell confocal microscopy found negligible localisation of the fluorescent complex within the digestive vacuole of the parasite. This eliminated the haem detoxification pathway as a potential mechanism of action. Similarly, no localisation of the complex within the parasitic nucleus was found, thus suggesting that this complex probably does not interfere with the DNA replication process. A substantial saturation of fluorescence from the complex was found near phospholipid structures such as the plasma and nuclear membranes but not in neutral lipid bodies. This indicates that an association with these membranes, or organelles such as the endoplasmic reticulum or branched mitochondrion, could be essential to the efficacies of these types of antimalarial compounds. 相似文献
59.
Eric W. Neuman Benjamin J. Lai Jeremy L. Watts Gregory E. Hilmas William G. Fahrenholtz Laura Silvestroni 《International Journal of Applied Ceramic Technology》2021,18(6):2224-2236
Densification behavior, microstructure, and mechanical properties of zirconium diboride (ZrB2) ceramics modified with a complex Zr/Si/O-based additive were studied. ZrB2 ceramics with 5–20 vol.% additions of Zr/Si/O-based additive were densified to >95% relative density at temperatures as low as 1400°C by hot-pressing. Improved densification behavior of ZrB2 was observed with increasing additive content. The most effective additive amount for densification was 20 vol.%, hot-pressed at 1400°C (∼98% relative density). Microstructural analysis revealed up to 7 vol.% of residual second phases in the final ceramics. Improved densification behavior was attributed to ductility of the silicide phase, liquid phase formation at the hot-pressing temperatures, silicon wetting of ZrB2 particles, and reactions of surface oxides. Room temperature strength ranged from 390 to 750 MPa and elastic modulus ranged from 440 to 490 GPa. Vickers hardness ranged from 15 to 16 GPa, and indentation fracture toughness was between 4.0 and 4.3 MPa·m1/2. The most effective additive amount was 7.5 vol.%, which resulted in high relative density after hot-pressing at 1600°C and the best combination of mechanical properties. 相似文献
60.
During the last ten years, techniques have been developed to measure the distribution of grain boundaries in polycrystals
as a function of both lattice misorientation and grain boundary plane orientation. This paper presents a brief overview of
the techniques used for these measurements and the principle findings of studies implementing these techniques. The most significant
findings are that grain boundary plane distributions are anisotropic, that they are scale invariant during normal grain growth,
that the most common grain boundary planes are those with low surface energies, that the grain boundary populations are inversely
correlated with the grain boundary energy, and that the coincident site lattice number is a poor predictor of the grain boundary
energy and population. 相似文献