ZSF合金抗钻性及复合韧化效果

研究了ＺＳＦ合金的显微组织及其抗钻削性和冲击韧性。结果表明,ＺＳＦ合金的显微组织是奥氏体＋共晶碳化物。该组织的硬度虽不很高（３５ＨＲＣ）却具有很强的抗钻削能力,其主要机制是钻削时加工硬化引起部分奥氏体转变成马氏体。该合金单体结构冲击韧性较低,与韧性好的Ｑ２３５Ａ钢焊接复合后抗冲击能力可明显提高。     

微米纳米科学技术发展及产业化启示

近年来,微米纳米科学技术发展迅速,在产业化方面已经取得了不少进展．本文从发展现状和趋势上,结合我国具体情况,阐述了以下观点：开展创新工艺和设计方法研究,提高微机电（加EMs）应用和产业化能力;开展基础研究,提高MEMS器件和系统的水平;加强微米／纳米科学技术成果的结合．最后对今后研究工作提出了建议．     

短壁综放面快速推进矿山压力显现规律与特征

通过分析短壁综放工作面快速推进条件下的矿压显现规律与特征,为今后类似条件的工作面巷道布置、支护参数选择等提供切实可靠的依据。对工作面回采提出有针对性的防范措施,实现工作面快速推进时的安全生产。     

Simultaneous determination of three pesticides and their metabolites in unprocessed foods using ultraperformance liquid chromatography-tandem mass spectrometry

We have developed a rapid, multi-compound analytical method for measuring residues of the pesticides thiamethoxam and its metabolite, clothianidin; fipronil and its three metabolites, fipronil sulfone, fipronil sulfide, and fipronil desulfinyl; and pyraclostrobin in unprocessed foods (rice, corn, cucumbers, tomatoes, apples, and bananas) by ultra-performance liquid chromatography coupled to tandem mass spectrometry. Acetonitrile was used as the extraction solvent, and an octadecylsilane-dispersive SPE was used to clean up the analytes, which were then separated through a UPLC HSS T3 column connected to a tandem mass spectrometer via an electrospray ionisation source. The linearity of this method for the target analytes was excellent (R² ≥0.990) in the concentration range of 5–1000 μg kg^–1. The average recoveries of the seven compounds at concentrations of 10, 100, and 1000 μg kg^–1 from six spiked matrix samples ranged from 73.6 to 110.6%, all with RSD values of ≤19.7%. The limit of quantification was 10 μg kg^–1. The method validated the effectiveness of the method for routine monitoring the residue of these pesticides and their metabolites in foods.     

Activation of TRPV4 Induces Exocytosis and Ferroptosis in Human Melanoma Cells

TRPV4 (transient receptor potential vanilloid 4), a calcium permeable TRP ion channel, is known to play a key role in endocytosis. However, whether it contributes to exocytosis remains unclear. Here, we report that activation of TRPV4 induced massive exocytosis in both melanoma A375 cell and heterologous expression systems. We show here that, upon application of TRPV4-specific agonists, prominent vesicle priming from endoplasmic reticulum (ER) was observed, followed by morphological changes of mitochondrial crista may lead to cell ferroptosis. We further identified interactions between TRPV4 and folding/vesicle trafficking proteins, which were triggered by calcium entry through activated TRPV4. This interplay, in turn, enhanced TRPV4-mediated activation of folding and vesicle trafficking proteins to promote exocytosis. Our study revealed a signaling mechanism underlying stimulus-triggered exocytosis in melanoma and highlighted the role of cellular sensor TRPV4 ion channel in mediating ferroptosis.     

水闸工程复核计算方法初探

结合日照市大沙洼林场防潮闸工程复核计算项目,简要介绍了河道管理范围内水闸工程复核计算的基本内容和方法,包括水闸的过流能力、消能防冲、渗透稳定、闸室稳定和结构受力计算等,并根据复核结果和工程现状提出了综合评价结论与建议.     

Effect of particle size distribution on green properties during high velocity compaction

Iron powders with two different particle size distributions were compacted by high velocity compaction. The influences of particle size distribution and impact velocity on green properties, including green density, springback, tensile strength and bending strength etc., were studied with scanning electron microscopy (SEM) and a computer controlled universal testing machine. The results show that the particle size distribution and the impact velocity strongly affect its properties. Wider size distribution results in green compact with higher density and better strength. Furthermore, springback of compacts is lower produced by the powder with wider size distribution, especially for radial springback. As impact velocity increases, its green density and green strength gradually increases, but the increasing rate of density decreases gradually. No special relation is found between springback and impact velocity. In addition, the axial springback and the bending strength are higher than the radial springback and the tensile strength, respectively.