Pharmacokinetic Comparison of Berberine in Rat Plasma after Oral Administration of Berberine Hydrochloride in Normal and Post Inflammation Irritable Bowel Syndrome Rats

In the present study, post inflammation irritable bowel syndrome (PI-IBS) rats were firstly established by intracolonic instillation of acetic acid with restraint stress. Then the pharmacokinetics of berberine in the rat plasma were compared after oral administration of berberine hydrochloride (25 mg/kg) to normal rats and PI-IBS rats. Quantification of berberine in the rat plasma was achieved by using a sensitive and rapid UPLC-MS/MS method. Plasma samples were collected at 15 different points in time and the pharmacokinetic parameters were analyzed by WinNonlin software. Compared with the normal group, area under the plasma concentration vs. time curve from zero to last sampling time (AUC_0–t) and total body clearance (CL/F) in the model group significantly increased or decreased, (2039.49 ± 492.24 vs. 2763.43 ± 203.14; 4999.34 ± 1198.79 vs. 3270.57 ± 58.32) respectively. The results indicated that the pharmacokinetic process of berberine could be altered in PI-IBS pathological conditions.     

Functional Composite Adsorbents Based on Metal-Organic Frameworks in a Carbon Matrix Applied for Methane Storage

Protection of Metals and Physical Chemistry of Surfaces - In the present work, a method for producing new shaped composite materials by introducing a metal-organic framework structure Cu-BTC110...     

Vapor-Phase Protection of Zinc from Atmospheric Corrosion by Low-Volatile Corrosion Inhibitors

Protection of Metals and Physical Chemistry of Surfaces - The atmospheric corrosion resistance of metals can be reached by the formation of ultrathin protective films on their surface. Over recent...     

高层转换结构设计探究

本文充分考虑到了高层转换结构设计的安全问题,并结合工程实例,就可能出现的缺陷及设计时应注意的方面展开了详细论述,使其能同时满足建筑功能和结构规范的要求。希望在成功总结了高层转换结构设计中的重点后,对于设计人员起到一定的指导作用。     

浅析光伏建筑结构一体化的发展及应用

大多数建筑物的形式都分为这样几类：传统的泥瓦墙建筑形式、木结构建筑、新型光伏建筑等形式。本文详细评测了光伏建筑结构的一体化发展现状以及实际的运用情况。     

孔子的工匠观

该文依据《论语》等先秦古籍,从工匠造物必须诚信、必须敬业、必须重视改进工具等13个方面论述了孔子的工匠思想。     

核电厂用水泥固定配方及设备研究

本文通过不同种类水泥和外加剂配比试验,研发了一种新的水泥灌浆固定配方,并设计了符合核电厂现场使用需求的水泥灌浆固定设备。现场试验结果表明,水泥浆粘聚性好,静置无泌水,流动度大于330mm,养护28天的水泥固定体抗压强度大于75MPa,抗Cl-离子渗透小于2 000C,具有优良的物理性能。     

混凝剂预处理非工艺低放废水研究

我国后处理工业示范厂和后处理大厂产生的非工艺低放废水具有年产生量大、成分复杂、污染核素种类多等特点。针对后处理非工艺低放废水的特点,初步探究了使用混凝剂处理非工艺低放废水的可行性。研究用非离子型聚丙烯酰胺(NPAM)为助凝剂,比较了聚合氯化铝(PAC)、聚合硫酸铁(PFS)、阴离子型聚丙烯酰胺(PAM)3种混凝剂对模拟非工艺低放废水中总有机碳(TOC)的去除效果。通过正交实验探讨了混凝效果的影响因素。结果表明:聚合氯化铝对模拟非工艺低放废水的混凝效果最佳,混凝剂的投加量是影响混凝效果的主要因素。当混凝剂和助凝剂的加入量分别为348 mg/L和24μg/L、混凝时间为30 min、pH=5时,得到去除模拟非工艺低放废水中TOC的最优方案,TOC去除率达到24%。     

适度技术本质设计——湖北省人民政府办公楼建筑设计

湖北省人民政府办公楼设计中深入贯彻"经济、实用、安全、美观"的原则。结合地区经济发展水平和地域气候特点,注重适度技术的创新性运用和现代政府办公建筑的本质设计。